proliferation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1768	Iriflophenone		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Iriflophenone stimulates cells proliferation in MCF-7 and T-47D human breast cancer.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
TN2054	Periplocymarin		Calcium Channel
	Periplocymarin is a cardiac glycoside with anticancer potential isolated from Periploca sepium and Periploca graeca.		Calcium Channel
T3855	Tracheloside		Estrogen Receptor/ERR , Phosphorylase
	Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml).		Estrogen Receptor/ERR , Phosphorylase
T27246	EG1		Others
	EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.		Others
TN1124	Neoeriocitrin		AChE
	Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.		AChE
TN6739	Angoline	6-Methoxyldihydrochelerythrine	IL Receptor , STAT
	Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits can...		IL Receptor , STAT
T3881	Vaccarin		Integrin , Akt , PERK , AMPK
	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.		Integrin , Akt , PERK , AMPK
T9118	KEA1-97		Apoptosis , Others , Caspase
	Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity ...		Apoptosis , Others , Caspase
T11363	Ganoderic acid F		Others
	Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium si...		Others
T8839	ICCB280		Apoptosis , Others
	ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavo...		Apoptosis , Others
T9111	8-Azaadenosine		Adenosine deaminase
	8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells.		Adenosine deaminase
T11960	MBM-55		GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase
	MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
T9810	TNIK-IN-5		Wnt/beta-catenin
	TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.		Wnt/beta-catenin
T15681	L-161982		Prostaglandin Receptor
	L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice.		Prostaglandin Receptor
TN2190	Scoulerine		Apoptosis , Beta-Secretase , BACE , Parasite
	Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.		Apoptosis , Beta-Secretase , BACE , Parasite
T12115	MSC2360844		PI3K
	MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).		PI3K
T7138	FB23-2		Apoptosis , Others
	FB23-2 is a potent and selective mRNA N6-methyladenosine (m6A) demethylase FTO inhibitor(IC50 : 2.6 μM).		Apoptosis , Others
T2055	WS3		EGFR , IκB/IKK
	WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.		EGFR , IκB/IKK
T2282	RPI-1		Others , Phospholipase , c-Met/HGFR , c-RET
	RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.		Others , Phospholipase , c-Met/HGFR , c-RET
T39785L	TH5427		NUDIX hydrolase
	TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).		NUDIX hydrolase