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BV6 TFA
Catalog No. T214873 Copy Product Info
🥰Excellent
BV6 TFA acts as an antagonist of the apoptosis inhibitory proteins (IAP) family members, cIAP1 and XIAP. It inhibits the proliferation of HCC193 cells, showing an IC50 value of 7.2 μM in an MTS assay. BV6 TFA can be utilized in studies relating to endometrial cancer and endometriosis.
BV6 TFA
Copy Product Info🥰Excellent
Catalog No. T214873
BV6 TFA acts as an antagonist of the apoptosis inhibitory proteins (IAP) family members, cIAP1 and XIAP. It inhibits the proliferation of HCC193 cells, showing an IC50 value of 7.2 μM in an MTS assay. BV6 TFA can be utilized in studies relating to endometrial cancer and endometriosis.
BV6 TFA
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BV6 TFA acts as an antagonist of the apoptosis inhibitory proteins (IAP) family members, cIAP1 and XIAP. It inhibits the proliferation of HCC193 cells, showing an IC50 value of 7.2 μM in an MTS assay. BV6 TFA can be utilized in studies relating to endometrial cancer and endometriosis. |
| In vitro | BV6 TFA (250 nM-30 μM, 24 h) induces apoptosis in HCC193 and H460 lung cancer cells in a concentration and time-dependent manner. Additionally, BV6 TFA increases the radiosensitivity of HCC193 and H460 cells. Specifically, treatment with BV6 TFA (1μM for 24 h; 5 μM for 48 h) significantly enhances radiosensitivity, with a dose enhancement ratio (DER) of 1.38 for HCC193 at 1 μM and 1.42 for H460 at 5 μM. |
| In vivo | BV6 TFA at a dosage of 10 mg/kg via i.p. injection twice a week for four weeks can reduce the expression of IAPs. This treatment also decreases the total number of lesions and the percentage of Ki67-positive cells compared to the control group. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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