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Chlovalicin
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Catalog No. TN10644Cas No. 179799-38-3
Chlovalicin is found in the [Streptomyces] FO-4649 strain. In the presence of 0.2 U/mL IL-6, Chlovalicin inhibits the growth of IL-6-dependent MH60 cells with an IC50 of 7.5 μM. It also suppresses the proliferation of B16 melanoma cells, exhibiting an IC50 of 38 μM. Additionally, Chlovalicin shows inhibitory activity against osteoclastogenesis.
Chlovalicin
😃Good
Catalog No. TN10644Cas No. 179799-38-3
Chlovalicin is found in the [Streptomyces] FO-4649 strain. In the presence of 0.2 U/mL IL-6, Chlovalicin inhibits the growth of IL-6-dependent MH60 cells with an IC50 of 7.5 μM. It also suppresses the proliferation of B16 melanoma cells, exhibiting an IC50 of 38 μM. Additionally, Chlovalicin shows inhibitory activity against osteoclastogenesis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Chlovalicin is found in the [Streptomyces] FO-4649 strain. In the presence of 0.2 U/mL IL-6, Chlovalicin inhibits the growth of IL-6-dependent MH60 cells with an IC50 of 7.5 μM. It also suppresses the proliferation of B16 melanoma cells, exhibiting an IC50 of 38 μM. Additionally, Chlovalicin shows inhibitory activity against osteoclastogenesis. |
| Molecular Weight | 332.82 |
| Formula | C16H25ClO5 |
| Cas No. | 179799-38-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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