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E6-272
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Catalog No. T89394Cas No. 945142-65-4
Alias E6272, E 6-272
E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively.
E6-272
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Purity: 99.82%
Catalog No. T89394Alias E6272, E 6-272Cas No. 945142-65-4
E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $42 | - | In Stock | |
| 5 mg | $93 | - | In Stock | |
| 10 mg | $148 | - | In Stock | |
| 25 mg | $298 | - | In Stock | |
| 50 mg | $448 | - | In Stock | |
| 100 mg | $672 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.82%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively. |
| In vitro | Methods: SIHA and CASKI cells were treated with E6-272 (15nM; 30nM, 48 hours) and apoptosis analysis was performed to evaluate the efficacy of E6-272 in inducing apoptosis in cervical cancer cells. Results: E6-272 (15nM) treatment of SIHA cells induced 27.85% early and 8.38% late apoptotic cell populations (Figure 8). E6-272 (30nM) treatment of CASKI cells showed 23.94% and 7.42% early and late apoptotic cell populations, respectively.[1] |
| Synonyms | E6272, E 6-272 |
| Molecular Weight | 384.51 |
| Formula | C26H28N2O |
| Cas No. | 945142-65-4 |
| Smiles | O=C(Cc1ccc(cc1)-c1ccccc1)NC1CCN(Cc2ccccc2)CC1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (20.81 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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