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TEAD-IN-21
Catalog No. T213127 Copy Product Info
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TEAD-IN-21 is a potent, orally bioavailable pan-TEAD inhibitor with an IC50 of 3 nM. It effectively suppresses proliferation in Huh-7 cells and selectively downregulates TEAD-dependent downstream genes. In mouse models with liver cancer-derived tumor xenografts, TEAD-IN-21 leads to tumor regression. This compound is applicable for hepatocellular carcinoma (HCC) research.
TEAD-IN-21
Copy Product Info🥰Excellent
Catalog No. T213127
TEAD-IN-21 is a potent, orally bioavailable pan-TEAD inhibitor with an IC50 of 3 nM. It effectively suppresses proliferation in Huh-7 cells and selectively downregulates TEAD-dependent downstream genes. In mouse models with liver cancer-derived tumor xenografts, TEAD-IN-21 leads to tumor regression. This compound is applicable for hepatocellular carcinoma (HCC) research.
TEAD-IN-21
| Pack Size | Price | USA Stock | Global Stock | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TEAD-IN-21 is a potent, orally bioavailable pan-TEAD inhibitor with an IC50 of 3 nM. It effectively suppresses proliferation in Huh-7 cells and selectively downregulates TEAD-dependent downstream genes. In mouse models with liver cancer-derived tumor xenografts, TEAD-IN-21 leads to tumor regression. This compound is applicable for hepatocellular carcinoma (HCC) research. |
| Targets&IC50 | TEAD:3 nM |
| In vitro | TEAD-IN-21 (Compound C11) demonstrates moderate inhibitory effects on Bel-7402, SNU182, and Li-7 cells at concentrations of 0.1-100 μM, and exhibits optimal inhibition on Huh-7 cells. At concentrations of 0.3-40 μM over 14 days, it significantly reduces colony formation in these cells while showing minimal activity in TEAD-insensitive liver cancer cell lines. TEAD-IN-21 (0-40 μM) also downregulates TEAD downstream gene transcription levels in a dose-dependent manner. |
| In vivo | TEAD-IN-21 (Compound C11) administered orally at a dose of 50 mg/kg once daily for 20 consecutive days effectively inhibits the growth of Huh-7 xenograft tumors in a mouse model. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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