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Membrane transporter/Ion channel

Monoamine Transporter

(43)

Monocarboxylate transporter

Na-K-Cl cotransporter

Sodium-dependent phosphate transporter

ASCT

Alanine Serine Cysteine Transporter (ASCT) belongs to the SLC1 family, comprising ASCT1 (SLC1A4) and ASCT2 (SLC1A5). ASCTs are sodium-dependent neutral amino acid exchanger transporters located on the cell membrane, regulating intracellular and extracellular neutral amino acid equilibrium. They play a pivotal role in maintaining amino acid metabolic balance under both physiological and pathological conditions. ASCT2 is particularly active in rapidly proliferating cells, including various cancer types, supporting tumour growth and mTOR signalling pathway activation by transporting key nutrients such as glutamine.

Filter HomeSignaling PathwaysMembrane transporter/Ion channelASCT

V-9302

T53451855871-76-9

V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).

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Cited

Agnuside

T386811027-63-7

Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.

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GPNA hydrochloride

T1541167953-08-6

GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits

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Idactamab

T773852245205-37-0

Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2. Idactamab can be used to prepare ADC MEDI7247.

$297

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L-4FPG

T2110219883-57-9

L-4FPG is a Glycine derivative, inhibits the neutral amino acid transporters ASCT1 and ASCT2.

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SN40 hydrochloride

T847542768663-15-4

SN40 hydrochloride is a potent inhibitor of amino acid transport (AAT), exhibiting inhibitory constants (Kis) of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM, and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1, and EAAT5, respectively. It is utilized in cancer research. [1]

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8-10 weeks

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V-9302 hydrochloride

T400642416138-42-4

V-9302 hydrochloride is a potent and selective competitive antagonist that inhibits transmembrane glutamine flux by specifically targeting the amino acid transporter ASCT2 (SLC1A5), and not ASCT1. In HEK-293 cells, V-9302 hydrochloride effectively inhibits ASCT2-mediated glutamine uptake with an IC50 value of 9.6 μM.

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bms-466442

T238061598424-76-0

BMS-466442 is the first selective amino acid transporter alanine serine cysteine transporter-1 inhibitor.

$983

35 days

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sn05

T607682768663-51-8

SN05 is a potent inhibitor of amino acid transport (AAT) that can be used in anticancer research. The Ki values of SN05 for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5 is 2.77 μM, 0.73 μM, 0.87 μM, 3.7 μM, 7.25 μM, 7.23 μM and 2.22 μM, respectively [1].

$1,520

6-8 weeks

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sn40

T606422768663-14-3

SN40 is a potent amino acid transport (AAT) inhibitor relevant for anticancer research, with Kis of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively [1].

$2,140

6-8 weeks

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