PLX3397 in AIN-76A Diet (290 ppm)

TargetMol’s PLX3397 in AIN-76A Diet (290 ppm) is a functional laboratory animal diet designed specifically for rodent research, in which the CSF1R inhibitor PLX3397 (Pexidartinib) is precisely quantified and incorporated into purified AIN-76A base diet. PLX3397 is an orally active tyrosine kinase inhibitor that specifically inhibits the signaling pathways of the colony-stimulating factor 1 receptor (CSF1R), c-Kit, and FLT3. In particular, by inhibiting CSF1R signaling, PLX3397 effectively regulates the survival, proliferation, and function of microglia and macrophages, making it widely used in research on neuroinflammation, neurodegenerative diseases, the tumor immune microenvironment, and the mechanisms of monocyte/macrophage-related diseases.
This product uses AIN-76A purified feed, which has well-defined composition and batch consistency, as a carrier. The PLX3397 content is 290 ppm (i.e., 290 mg of PLX3397 per 1 kg of AIN-76A feed). It enables continuous and stable administration via ad libitum feeding, helping to improve the reproducibility and consistency of experimental results. Additionally, the product includes an equal amount of AIN-76A feed without PLX3397 as a blank control, facilitating experimental grouping and comparison of results.