neu

NEU-1045 is a T. brucei proliferation inhibitor, and is a promising lead with cross-pathogen activity. NEU-1045 inhibited T. brucei, T. cruzi, and L. major proliferation with good potency (T. brucei EC50 = 0.37 μM; T. cruzi EC50 = 2.8 μM; L. major EC50 =

NEU-1923 is a potent inhibitor of T. brucei proliferation (EC50= 0.37 μM).

P-3FAX-Neu5Ac is a sialic acid analog and a sialyltransferase inhibitor.

Affibody (affibody) ligands that are specific for the extracellular domain of human epidermal growth factor receptor 2 (HER2/neu) have been selected by phage display technology from a combinatorial protein library based on the 58 amino acid residue staphy

HER2/neu (654-662) GP2 acetate is derived from the human epidermal growth factor receptor 2 (HER2-Neu, 654–662). HER2/neu (654-662) GP2 acetate induces HLA-A2-restricted cytotoxic T lymphocytes reactive to various epithelial cancers.

Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be used in studies of sleep-promoting, pain-relieving, anti-neurodegenerative, and antidepressant diseases. diseases, and can be used to improve memory deficits associated with chronic mild stress-induced lack of pleasure in rats.

Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 with an IC50 of 1 μM, demonstrating 100- and 500-fold higher selectivity for ErbB2 over EGFR and PDGFR, respectively.

Nelonemdaz Na is a NMDA receptor antagonist potentially for the treatment of stroke.

GW837016X, also known as NEU-391, is a potent inhibitor of protozoan parasite proliferation. GW837016X extended life of treated mice by 50%, compared to untreated controls. At the cellular level, GW837016X inhibited mitosis and cytokinesis in T. brucei.

IC2418 is an MmpL3 inhibitor, being active against drug-resistant Mycobacterium tuberculosis.

NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.

NEU-1953 is a potential candidate for sleeping sickness.

Anti-Human/Rat HER2 (neu) Antibody (7.16.4) is a mouse-derived IgG2a, κ monoclonal antibody inhibitor that targets human or rat HER2.

NEU3-IN-2 (compound 963), a derivative of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) and a C9 biphenylcarbamate, functions as an inhibitor of NEU3, a human neuraminidase with four isozymes. This compound exhibits inhibitory activity with a Ki of 0.12 μM and an IC50 of 0.31 μM. It serves as a crucial tool in the exploration of NEU3 isozyme functionality. Additionally, its analogs, featuring an amide and a triazole linker, show selectivity towards NEU1 and NEU4 isozymes, respectively.

NEU-730, a novel inhibitor of TbrPDEB1, shows modest inhibition of T. brucei proliferation.

NEU617 is an inhibitor of the growth of protozoan parasites, against T. brucei bloodstream proliferation.

Neu5Acα(2-3)Galβ MP glycoside is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Neu5Gc(α2,6)N-Acetylgalactosamine is a type of biochemical reagent used in glycoscience research. Glycoscience studies the structure, synthesis, biology, and evolution of sugars. This field encompasses carbohydrate chemistry, the enzymatic formation and degradation of glycans, protein-glycan interactions, and the roles of glycans within biological systems. It is closely connected to fundamental research, biomedicine, and biotechnology.

Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

C18:0 GM2(Neu5Gc) Ceramide (d18:1/18:0) is a type of sphingolipid.

C18:0 GM3(Neu5Gc) Ceramide (d18:1/18:0) is a type of sphingolipid.