interleukin

Interleukin 1beta is a bioactive chemical.

β-Interleukin II is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH.

Interleukin II (60-70) is a peptide with the sequence NH2-LEU-THR-PHE-LYS-PHE-TYR-MET-PRO-LYS-LYS-ALA-COOH, MW=1373.7. Interleukin 2 (IL-2) is a type of cytokine signaling molecule in the immune system, regulating the activities of white blood cells.

β-Interleukin I (163-171), human Acetateis a peptide that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.

Fibrinogen is a heterodimeric protein that can be cleaved by thrombin. Fibrinogen is a potential marker for cardiovascular disease and plays an important role in metabolism. Its absence can cause fibrinogenemia.

Interleukin-6 Fragment (human) is a pleiotropic cytokine originating from both lymphocytes and non-lymphocytes, encoded by a gene on human chromosome 7 spanning roughly 5 kilobases. This fragment shows promise for use in immune response regulation, acute phase reactions, inflammatory processes, oncology, and hematopoiesis [1].

Interleukin (IL)-6 Receptor, a peptide, binds to IL-6 facilitating signal transduction and playing a crucial role in inflammatory and immune responses.

Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity, inhibits cancer cell growth, and inhibits the production of mature IL-lβ. Ac-YVAD-CHO attenuates quinolinic acid-induced p53 increase and apoptosis in rat striatum.

Erepdekinra is an interleukin-17A (IL-17A) receptor antagonist [1].

Myelopeptide-2, a peptide isolated from the supernatant of porcine bone marrow cell cultures, can restore the mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. It also enhances depressed interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression, playing a role in immunity homeostasis. This compound shows potential for application in antitumor and antivirus research [1] [2].

YVAD-CHO is an inhibitor of interleukin-1β converting enzyme (ICE, caspase 1) that has been shown to partially mitigate motoneuron death in mice with lesioned facial nerves [1].

Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.

Lyn Peptide Inhibitor TFA is a powerful, cell-permeable inhibitor specifically targeting the Lyn-coupled IL-5 receptor signaling pathway, without affecting alternative signaling pathways. It effectively prevents Lyn activation and impedes the association between Lyn tyrosine kinase and the βc subunit of IL-3/GM-CSF/IL-5 receptors. This compound is utilized in the investigation of asthma, allergic reactions, and various eosinophilic conditions [1].

Acetyl hexapeptide-49, recognized for its anti-allergenic properties, is a bioactive peptide commonly utilized as a cosmetic ingredient [1].

Citrullinated LL-37 1cit, a modified LL-37 peptide, retains the antiviral properties of its parent compound against human rhinovirus and exhibits antibacterial activity against S. aureus. Furthermore, it diminishes the RV1B-induced expression of pro-inflammatory cytokines, including IL-8, CCL5, and IL-6 mRNA [1].

Citrullinated LL-37 2cit, a modified version of the LL-37 peptide, attenuates the antiviral efficacy of LL-37 against Human Rhinovirus (HRV) at a concentration of 10 μg/mL and diminishes its antibacterial properties. Furthermore, the compound diminishes RV1B-induced mRNA expression of pro-inflammatory cytokines IL-8, CCL5, and IL-6, and demonstrates a moderate decline in suppressing HRV-stimulated CCL5 secretion [1].

Lib2-1, a macrocyclic peptide, inhibits the interaction between IL-17C and IL-17RE and is applicable in studying autoimmune and inflammatory diseases [1].

Pep-1 (uncapped), which has 21 amino acid residues, is a known carrier peptide that delivers full-length native proteins in vitro and in vivo.

Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. In

Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in

Romurtide is a synthetic muramyl dipeptide analog and can be used for the prophylaxis of leukocytopenia during radiation therapy.

SPA4 is a peptide that interacts with TLR4. It suppresses the LPS-induced TNF-α cytokine response without affecting cell viability or size.

RS17 is a synthetically designed antitumor peptide that specifically binds to the CD47 molecule, inhibiting the interaction between CD47 and its ligand SIRPα on the macrophage surface membrane. The primary regulatory mechanism of RS17 involves blocking the transmission of the selective phagocytosis signal from CD47 to SIRPα, preventing macrophages from identifying tumor cells as self, and instead treating them as foreign substances for phagocytosis, thereby inhibiting tumor cell immune evasion. RS17 is applicable in studies of antitumor responses and immune evasion mechanisms.

DOTA-Pep-1L TFA is a peptide resulting from the conjugation of DOTA with Pep-1L, where Pep-1L specifically targets the IL13RA2 receptor. DOTA-Pep-1L TFA is utilized in PET imaging and research on tumor-targeted therapies.