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CF-Carvacrol
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Catalog No. T211974
CF-Carvacrol is an orally active lipid-lowering agent synthesized by combining Carvacrol and Clofibric acid. It shows strong affinity for PPAR-α and demonstrates significant hypolipidemic activity. Additionally, CF-Carvacrol exerts antioxidant and anti-inflammatory effects by activating the Nrf2/HO-1 signaling pathway, thereby alleviating liver damage. This compound is applicable in research on liver injury induced by cystic fibrosis.
CF-Carvacrol
CF-Carvacrol
😃Good
Catalog No. T211974
CF-Carvacrol is an orally active lipid-lowering agent synthesized by combining Carvacrol and Clofibric acid. It shows strong affinity for PPAR-α and demonstrates significant hypolipidemic activity. Additionally, CF-Carvacrol exerts antioxidant and anti-inflammatory effects by activating the Nrf2/HO-1 signaling pathway, thereby alleviating liver damage. This compound is applicable in research on liver injury induced by cystic fibrosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | CF-Carvacrol is an orally active lipid-lowering agent synthesized by combining Carvacrol and Clofibric acid. It shows strong affinity for PPAR-α and demonstrates significant hypolipidemic activity. Additionally, CF-Carvacrol exerts antioxidant and anti-inflammatory effects by activating the Nrf2/HO-1 signaling pathway, thereby alleviating liver damage. This compound is applicable in research on liver injury induced by cystic fibrosis. |
| In vivo | CF-Carvacrol, administered orally at doses of 46.3-185.2 mg/kg (0.1335-0.534 mmol/kg) daily for 7 days, demonstrates a significant dose-dependent lipid-lowering effect in hyperlipidemic Kunming (KM) mice. Furthermore, at a dose of 572.3 g/kg (1.65 mol/kg) given daily for one month, it reduces plasma levels of AST, ALT, and AKP, alleviates oxidative stress and inflammation, and improves liver tissue morphology in KM mice. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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