Select your Country or Region

  • TargetMol | Compound LibraryArgentinaArgentina
  • TargetMol | Compound LibraryAustraliaAustralia
  • TargetMol | Compound LibraryAustriaAustria
  • TargetMol | Compound LibraryBelgiumBelgium
  • TargetMol | Compound LibraryBrazilBrazil
  • TargetMol | Compound LibraryBulgariaBulgaria
  • TargetMol | Compound LibraryCroatiaCroatia
  • TargetMol | Compound LibraryCyprusCyprus
  • TargetMol | Compound LibraryCzechCzech
  • TargetMol | Compound LibraryDenmarkDenmark
  • TargetMol | Compound LibraryEgyptEgypt
  • TargetMol | Compound LibraryEstoniaEstonia
  • TargetMol | Compound LibraryFinlandFinland
  • TargetMol | Compound LibraryFranceFrance
  • TargetMol | Compound LibraryGermanyGermany
  • TargetMol | Compound LibraryGreeceGreece
  • TargetMol | Compound LibraryHong KongHong Kong
  • TargetMol | Compound LibraryHungaryHungary
  • TargetMol | Compound LibraryIcelandIceland
  • TargetMol | Compound LibraryIndiaIndia
  • TargetMol | Compound LibraryIrelandIreland
  • TargetMol | Compound LibraryIsraelIsrael
  • TargetMol | Compound LibraryItalyItaly
  • TargetMol | Compound LibraryKoreaKorea
  • TargetMol | Compound LibraryLatviaLatvia
  • TargetMol | Compound LibraryLebanonLebanon
  • TargetMol | Compound LibraryMalaysiaMalaysia
  • TargetMol | Compound LibraryMaltaMalta
  • TargetMol | Compound LibraryMoroccoMorocco
  • TargetMol | Compound LibraryNetherlandsNetherlands
  • TargetMol | Compound LibraryNew ZealandNew Zealand
  • TargetMol | Compound LibraryNorwayNorway
  • TargetMol | Compound LibraryPolandPoland
  • TargetMol | Compound LibraryPortugalPortugal
  • TargetMol | Compound LibraryRomaniaRomania
  • TargetMol | Compound LibrarySingaporeSingapore
  • TargetMol | Compound LibrarySlovakiaSlovakia
  • TargetMol | Compound LibrarySloveniaSlovenia
  • TargetMol | Compound LibrarySpainSpain
  • TargetMol | Compound LibrarySwedenSweden
  • TargetMol | Compound LibrarySwitzerlandSwitzerland
  • TargetMol | Compound LibraryTaiwan,ChinaTaiwan,China
  • TargetMol | Compound LibraryThailandThailand
  • TargetMol | Compound LibraryTurkeyTurkey
  • TargetMol | Compound LibraryUnited KingdomUnited Kingdom
  • TargetMol | Compound LibraryUnited StatesUnited States
  • TargetMol | Compound LibraryOther CountriesOther Countries
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • Apoptosis
    (23)
  • COX
    (15)
  • ERK
    (10)
  • Endogenous Metabolite
    (9)
  • IL Receptor
    (28)
  • Interleukin
    (14)
  • NF-κB
    (49)
  • TNF
    (120)
  • p38 MAPK
    (10)
  • Others
    (194)
Filter
Search Result
Results for "TNF" in TargetMol Product Catalog
  • Inhibitor Products
    464
    TargetMol | Activity
  • Recombinant Protein
    195
    TargetMol | inventory
  • Natural Products
    136
    TargetMol | natural
  • Peptides Products
    39
    TargetMol | composition
  • Antibodies Products
    23
    TargetMol | Activity
  • Compound Libraries
    5
    TargetMol | inventory
  • Isotope products
    5
    TargetMol | natural
  • PROTAC Products
    4
    TargetMol | composition
  • Dye Reagents
    2
    TargetMol | Activity
TNF/IFNγ-IN-1
T83628876013-29-5
TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.
  • $195
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TNF-α-IN-9
T774942054199-25-4
TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.
  • $68
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TNF-α (31-45), human acetate
T19584L
TNF-α (31-45), human acetate is a peptide of tumor necrosis factor-α.
  • $133
In Stock
Size
QTY
TargetMol | Citations Cited
TNF-α-IN-8
T80973444287-85-8
TNF-α-IN-8 (compound I-42) is an isoindole-imide-based inhibitor of tumor necrosis factor-alpha (TNF-α) with applications in researching various diseases including cancer, heart disease, osteoporosis, and autoimmune disorders. Additionally, this compound serves as a click chemistry reagent, possessing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) or strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Alkyne, DBCO, or BCN groups.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
TNF-α (46-65), human
TP1626144796-72-5
Human TNF alpha (46-65) peptide.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
T81838192723-42-5
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) is a peptide utilized as a fluorescence resonance energy transfer (FRET) based substrate for proteolytic activity assays, wherein the cleavage-induced change in fluorescence intensity serves as the measure of enzymatic activity [1].
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
TNF-α (31-45), human TFA (144796-71-4 free base)
TP1636
TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α.
  • $220
Backorder
Size
QTY
TargetMol | Inhibitor Sale
TNF-α-IN-6
T403212699704-20-4
TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
  • $936
Backorder
Size
QTY
TargetMol | Inhibitor Sale
TNF-α (31-45), human
T19584144796-71-4
TNF-α (31-45), human is a peptide of tumor necrosis factor-α.
  • Inquiry Price
Size
QTY
TNF-α Antagonist
T36127199999-60-5
TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.
  • $296
35 days
Size
QTY
TNF Protease Inhibitor 2
TQ0129187034-31-7
TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).
  • Inquiry Price
Size
QTY
Anti-Mouse TNF alpha Antibody (TN3-19.12)
T78272
Anti-Mouse TNF alpha Antibody is a rat-derived IgG inhibitor targeting mouse TNF alpha.
  • Inquiry Price
Size
QTY
TNF-α-IN-11
T78730
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM. By binding to TNF-α, it impedes TNF-α-induced caspase activation and the NF-κB signaling pathway. Additionally, it suppresses the phosphorylation of IκBα and the nuclear migration of NF-κB p65. This compound is utilized in the study of TNF-α-mediated autoimmune diseases [1].
  • Inquiry Price
Size
QTY
R-7050
T4637303997-35-5
R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.
  • $38
In Stock
Size
QTY
TargetMol | Citations Cited
TNF-α-IN-2
T360972074702-04-6
TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].
  • $2,450
10-14 weeks
Size
QTY
TNF-α-IN-1
T13175444287-49-4
TNF-α-IN-1 is a TNF-α inhibitor.
  • $76
5 days
Size
QTY
TNF-α (10-36), human (TFA) (144796-70-3 free base)
TP1479
TNF-α (10-36), human (TFA) is a peptide of human TNF-α.
  • Inquiry Price
Size
QTY
KP-457
T777781365803-52-6
KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17, with an IC50 value of 11.1 nM/L in cell-free assays. The compound can also cleave a variety of molecules, including GPIbα, GPV and TNF-α.
  • $93
5 days
Size
QTY
TNF-α-IN-10
T790252247720-56-3
TNF-α-IN-10 (compound 8a) acts as an inhibitor of IL-6 and TNF-α, demonstrating anti-inflammatory activity [1].
  • $1,520
6-8 weeks
Size
QTY
TNF-α (46-65), human TFA (144796-72-5 free base)
TP1669
TNF-α (46-65), human (TFA) is a peptide of human TNF-α.
  • Inquiry Price
Size
QTY
TNF-α (10-36), human
TP1537144796-70-3
TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response.
  • Inquiry Price
Size
QTY
TNF-α (31-45), human TFA
T76026
TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α. Tumour necrosis factor alpha (TNF alpha) is an inflammatory cytokine that induces necrosis or apoptosis [1] .
  • Inquiry Price
Size
QTY
MSA-2
T8798129425-81-6
MSA-2 is a potent and orally available non-nucleotide STING agonist.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Etanercept
T37445185243-69-0
Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β to the TNF receptors on cell surfaces, thereby rendering TNF biologically inactive. Etanercept has demonstrated efficacy in treating rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.
  • $328
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Infliximab
T9921170277-31-3
Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.
  • $98
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Adalimumab
T9901331731-18-1
Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.
  • $213
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Necrostatin-1
T18474311-88-0
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Sanggenon C
T4S161580651-76-9
1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO production and iNOS expression by suppressing NF-κB activity and IκBα activation; inhibited TNF-alpha -stimulated PMN-HSC adhesion and expression of VCAM-1 by suppressing the activation of NF-kappaB.
  • $97
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
RV01
T127811016897-10-1
RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduces iNOS expression and has anti-neuroinflammatory effects. rV01 reduces tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion. RV01 reduced tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion, inhibited lps-induced ROS production and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation, decreased toll-like receptor 4 (TLR4) protein expression, and inhibited lps-induced activation of mitogen-activated protein kinase (MAPK) and nuclear transcription factor-кB (NF-кB) signaling pathways.
  • $93
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Theophylline monohydrate
T1083L5967-84-0
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Physiologically, this agent relaxes the bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates the cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm.
  • $38
In Stock
Size
QTY
Apremilast
T2923608141-41-9
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
  • $43
In Stock
Size
QTY
Cepharanthine
T0131481-49-2
Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production.
  • $45
In Stock
Size
QTY
TargetMol | Citations Cited
Eleutheroside E
T366239432-56-9
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the generation of TNF-α and IL-6, the m
  • $35
In Stock
Size
QTY
TargetMol | Citations Cited
Cot inhibitor-1 hydrochloride
T10865L In house
Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 = 5.7 nM).
  • $127
In Stock
Size
QTY
TargetMol | Inhibitor Sale
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea
T601242379727-88-3In house
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea, a TNF-α agonistic compound, could induce cells to secrete TNF- α.
  • $117
In Stock
Size
QTY
4-methoxylonchocarpin
TN723551589-67-4
4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TNF expression by inhibiting the binding of LPS to TLR4 in macrophages and suppressed TNBS-induced colitis in mice.
  • $195
In Stock
Size
QTY
TargetMol | Inhibitor Sale
(R)-STU104
T606572767124-77-4
(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathway by binding to MKK3 and disrupting TAK1 phosphorylation of MKK3. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.
  • $195
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Ataquimas
T9840586348-21-2In house
Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.
  • $55
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Naphazoline
T21445835-31-4
Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.
  • $50
In Stock
Size
QTY
Compound Lup-20(29)-en-3-yl acetate
TC0036
Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
  • $89
In Stock
Size
QTY
TargetMol | Inhibitor Sale
K-7174
T11742191089-59-5
K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.
  • $78
In Stock
Size
QTY
ABzOH
T679241313028-09-9
ABzOH is a benzoic acid derivative, similar in structure to non-steroidal anti-inflammatory drugs such as aspirin, with anti-inflammatory, anti-tumor and anti-proliferative effects. ABzOH can not only inhibit the expression of tumor necrosis factor-α (TNF-a), interleukin-1β (IL-1β), interleukin-6 (IL-6) and other pro-inflammatory cytokines, but also inhibit breast cancer, lung cancer and pancreatic cancer.
  • $195
In Stock
Size
QTY
LASSBio-1135
T8440852453-71-5
LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
  • $133
In Stock
Size
QTY
IKKγ NBD Inhibitory Peptide acetate
TP1615L
IKKγ NBD Inhibitory Peptide acetate is a NEMO-binding domain peptide (NBD peptide) acetate corresponding to the NEMO amino-terminal alpha-helical region. IKKγ NBD Inhibitory Peptide acetate is shown to block TNF-alpha-induced NF-kB activation.
  • $133
In Stock
Size
QTY
GSK-J4
T31001373423-53-0In house
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.
  • $51
In Stock
Size
QTY
TargetMol | Citations Cited
Cot inhibitor-2
T10866915363-56-3In house
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α production in human whole blood with an IC50 of 0.3 μM.
  • $93
In Stock
Size
QTY
TargetMol | Inhibitor Sale
CU-115
T96452471982-20-2In house
CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells.
  • $53
In Stock
Size
QTY
TargetMol | Inhibitor Sale
3-Hydroxykynurenamine
T6818299362-47-7In house
3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis by decreasing skin thickness, erythema, scaling and fissuring, reducing TNF, IL-1β, IFN-γ, and IL-17 production, and inhibiting generation of effector CD8+ T cells. Similarly, in a mouse model of nephrotoxic nephritis, besides reducing inflammatory cytokines, 3-HKA improves proteinuria and serum urea nitrogen, overall ameliorating immune-mediated glomerulonephritis and renal dysfunction.
  • $1,520
6-8 weeks
Size
QTY
Cot inhibitor-1
T10865915365-57-0In house
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer.
  • $70
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Vialinin A
T22168858134-23-3In house
Vialinin A (Terrestrin A), a p-terphenyl compound, exhibits antioxidant properties and acts as a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Its efficacy in autoimmune diseases and cancer research is noteworthy, highlighting its potential therapeutic applications.
  • $213
In Stock
Size
QTY