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Furathiocarb
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Catalog No. T218767 Copy Product Info
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Furathiocarb is a carbamate precursor insecticide (insecticide) and a contact allergen. It is commonly used in studies related to contact allergies. Furathiocarb induces significant proliferation of MHCII-positive B cells in ear lymph node cells and prompts the generation of Th1 cell cytokines, such as IL-2, TNF-γ, and IFN-γ. However, it does not cause respiratory allergy in mice. After absorption through the excised rat abdomen skin, Furathiocarb is completely metabolized to carbofuran, with penetration increasing over time and dose. The skin penetration rates of Furathiocarb's emulsifiable concentrate (EC) and wettable powder (WP) formulations are higher than that of Furathiocarb itself, with no significant difference between the two formulations.
Cas No. 65907-30-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Furathiocarb is a carbamate precursor insecticide (insecticide) and a contact allergen. It is commonly used in studies related to contact allergies. Furathiocarb induces significant proliferation of MHCII-positive B cells in ear lymph node cells and prompts the generation of Th1 cell cytokines, such as IL-2, TNF-γ, and IFN-γ. However, it does not cause respiratory allergy in mice. After absorption through the excised rat abdomen skin, Furathiocarb is completely metabolized to carbofuran, with penetration increasing over time and dose. The skin penetration rates of Furathiocarb's emulsifiable concentrate (EC) and wettable powder (WP) formulations are higher than that of Furathiocarb itself, with no significant difference between the two formulations. |
| In vivo | Furathiocarb, when applied topically at concentrations of 0.1-3% once daily for three consecutive days, shows skin sensitizing activity in female CBA/Jn mice, with a positive local lymph node test observed at a 3% dose and an EC3 value of 1.08%. In female BALB/c mice, furathiocarb, administered for sensitization via topical application (1%) and for challenge via intratracheal instillation (0.01-0.1%), over sensitization periods of days 1-3, 8-10, and 15-17, with a single challenge dose on day 31, does not significantly activate Th2 in lung-draining lymph nodes nor does it induce respiratory allergen immune characteristics. |
| Molecular Weight | 382.47 |
| Formula | C18H26N2O5S |
| Cas No. | 65907-30-4 |
| Smiles | O=C(OC1=CC=CC2=C1OC(C)(C)C2)N(SN(C(=O)OCCCC)C)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Furathiocarb chemical structure | Furathiocarb in vivo | Furathiocarb formula | Furathiocarb molecular weight
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