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JAK1-IN-20
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Catalog No. T218659 Copy Product Info
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JAK1-IN-20 (Compound 38) is a gut-restricted, orally active, selective JAK1 inhibitor with an IC50 of less than 0.5 nM. It inhibits the enzymatic activity of JAK1, reduces the production of pro-inflammatory cytokines (TNF-α, IL-6), and suppresses the phosphorylation of STAT3. JAK1-IN-20 shows potential in improving ulcerative colitis and is used in inflammatory bowel disease research.
JAK1-IN-20
Cas No. 3106963-85-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | JAK1-IN-20 (Compound 38) is a gut-restricted, orally active, selective JAK1 inhibitor with an IC50 of less than 0.5 nM. It inhibits the enzymatic activity of JAK1, reduces the production of pro-inflammatory cytokines (TNF-α, IL-6), and suppresses the phosphorylation of STAT3. JAK1-IN-20 shows potential in improving ulcerative colitis and is used in inflammatory bowel disease research. |
| Targets & IC50 | JAK1:<0.5 nM |
| In vitro | JAK1-IN-20 is a potent and selective inhibitor of JAK1 enzyme activity, with an IC50 of less than 0.5 nM. It demonstrates selectivity over JAK2, JAK3, and TYK2 by more than 312-fold, 20,000-fold, and 354-fold, respectively. JAK1-IN-20 (30 min) effectively inhibits the IL-6-induced JAK/STAT3 signaling pathway in HEK-Blue IL-6 cells, with an IC50 of 28.0 nM. |
| In vivo | JAK1-IN-20 (10-30 mg/kg; oral administration; once daily) significantly alleviates acute ulcerative colitis induced by DSS in female C57BL/6J mice, reducing disease activity, increasing colon length, inhibiting the production of pro-inflammatory cytokines, and improving the histopathological features of colon tissue. |
| Molecular Weight | 537.97 |
| Formula | C26H25ClFN7O3 |
| Cas No. | 3106963-85-0 |
| Smiles | O=C1NCC2=CC(=CC=C12)NC3=NC=C(Cl)C(=N3)NC4CCN(C(=O)NC5=CC=C(C=C5F)C(=O)C)CC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: JAK1-IN-20 in vivo | JAK1-IN-20 in vitro | JAK1-IN-20 formula | JAK1-IN-20 molecular weight
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