Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pass through prefabricated hTNF/hTNFR1 complexes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 451.00 | |
50 mg | In stock | $ 663.00 | |
100 mg | In stock | $ 945.00 | |
500 mg | In stock | $ 1,880.00 |
Description | UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pass through prefabricated hTNF/hTNFR1 complexes. |
Targets&IC50 | TNF-α:9 nM(KD) |
In vitro |
UCB-5307 exhibits inhibition against wild-type TNF but does not inhibition against L57F TNF. The half-life of UCB-5307 is determined to be 3.3 hours.[1] UCB-5307 disrupts a preexisting complex between hTNF and hTNFR1, penetrating the complex and displacing one of the receptors. Prior exposure of hTNF to UCB-5307 prevents one receptor from binding.[1] |
Molecular Weight | 343.42 |
Formula | C22H21N3O |
CAS No. | 1515887-44-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (131.0 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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UCB-5307 1515887-44-1 Apoptosis TNF inhibitor inhibit