Shopping Cart

Your shopping cart is currently empty

UCB-5307

Name: UCB-5307
Brand: TargetMol
SKU: T61111
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T61111Cas No. 1515887-44-1

UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pass through prefabricated hTNF/hTNFR1 complexes.

UCB-5307

🥰Excellent

Purity: 98.76%

Catalog No. T61111Cas No. 1515887-44-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$451	In Stock	In Stock
50 mg	$663	In Stock	In Stock
100 mg	$945	-	In Stock
500 mg	$1,880	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.76%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pass through prefabricated hTNF/hTNFR1 complexes.
Targets&IC50	TNF-α:9 nM(KD)
In vitro	UCB-5307 exhibits inhibition against wild-type TNF but does not inhibition against L57F TNF. The half-life of UCB-5307 is determined to be 3.3 hours.[1] UCB-5307 disrupts a preexisting complex between hTNF and hTNFR1, penetrating the complex and displacing one of the receptors. Prior exposure of hTNF to UCB-5307 prevents one receptor from binding.[1]

Chemical Properties

Molecular Weight	343.42
Formula	C₂₂H₂₁N₃O
Cas No.	1515887-44-1
Smiles	Cc1ccc(C)c(Cn2c(nc3ccccc23)C(O)c2ccncc2)c1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (189.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9119 mL	14.5594 mL	29.1189 mL	145.5943 mL
5 mM	0.5824 mL	2.9119 mL	5.8238 mL	29.1189 mL
10 mM	0.2912 mL	1.4559 mL	2.9119 mL	14.5594 mL
20 mM	0.1456 mL	0.7280 mL	1.4559 mL	7.2797 mL
50 mM	0.0582 mL	0.2912 mL	0.5824 mL	2.9119 mL
100 mM	0.0291 mL	0.1456 mL	0.2912 mL	1.4559 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc