Home Tools
Log in
Cart

Search Result

Search Results for " autophagy "

Targets

1065

Compounds

20

Recombinant Proteins

5

Libraries

Cat No. Product Name
T1537 Rapamycin HOT Sirolimus,AY 22989,NSC-2260804 Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
Rapamycin (AY 22989), a macrolide compound obtained from Streptomyces hygroscopicus, is a potent and specific mTOR inhib...
T9181 Autophagy-IN-A9 Others
Autophagy-IN-A9 is a bioactive chemical.
T38977 Autophagy-IN-C1 Autophagy-IN-C1
Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea. Autophagy-IN-C1 not only induces apoptosis but also b...
T63744 Autophagy inducer 4
Autophagy inducer 4 is a Mannich base derivative based on Magnolol and can be used as an anticancer agent. autophagy ind...
T60749 Autophagy-IN-2
Autophagy-IN-2 (Compound 7h) is an inhibitor of autophagic flux which induces cancer cell apoptosis and can be used for ...
T61580 Autophagy inducer 3
Autophagy Inducer 3 is a chemical compound that exhibits autophagy-induced activity, specifically inducing robust autoph...
T62331 Autophagy-IN-1
Autophagy-IN-1 is a potent inhibitor of autophagy/mitophagy, blocking autophagosomal-lysosomal fusion in cancer cells wh...
T28001 MDK-6983 MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983 Autophagy
MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells...
T26683 AUTEN-67 Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67
AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUT...
T6468 D-glutamine Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic ...
T11142 EACC Autophagy
EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosom...
T14346 Aumitin Others , Autophagy
Aumitin is a diaminopyrimidine-based autophagy inhibitor. Aumitin inhibits starvation- and rapamycin induced autophagy d...
T5763 Sedanolide Others , Autophagy
Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery.
T5793 Britannin Apoptosis , AMPK , Autophagy
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pat...
T5S1287 Ligustilide Apoptosis , Autophagy
3-Butylidene-4,5-dihydrophthalide is an effective constituent extracted from Angelica sinensis.
T1554 Iohexol Mitophagy , Autophagy
Iohexol is a contrast agent. The osmolality of iohexol ranges from 322 mOsm/kg-approximately 1.1 times that of blood pla...
T5S1099 Liensinine Apoptosis , Mitophagy , Others , Autophagy
1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.
T5211 NSC 185058 NSC185058 Cysteine Protease , Autophagy
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
T3400 Bakuchiol p38 MAPK , DNA/RNA Synthesis , Autophagy
Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymera...
T0876 Clioquinol Chinoform,Iodochlorhydroxyquin Mitophagy , Antibiotic , Autophagy , Antifungal
Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline ...
1 2 3 4 5 ... 54
Cat No. Product Name Species Source
TMPJ-01192 ELAPOR1 Protein, Human, Recombinant (His) Human Human Cells
Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated with breast and endometrial cancers,but its mechanism of action remains unknown.May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. That EIG121 is a good endometrial biomarker associated with a hyperestrogenic state and estr...
TMPJ-01329 ATG5 Protein, Human, Recombinant Human E. coli
ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an impor...
TMPJ-01250 ATG4A Protein, Human, Recombinant (His) Human E. coli
Cysteine Protease ATG4A (ATG4A) is a cytoplasmic protein that belongs to the peptidase C54 family. ATG4A is widely expressed in many tissues at a low level, but the highest expression is observed in skeletal muscle and brain. ATG4A is a cysteine protease required for autophagy; it cleaves the C-terminal part of MAP1LC3, GABARAPL2 or GABARAP. ATG4A is inhibited by N-ethylmaleimide. It is suggested that ATG4A has a significant role in suppressing various cancers.
TMPJ-01327 ATG10 Protein, Human, Recombinant (His, T7) Human E. coli
Ubiquitin-Like-Conjugating Enzyme ATG10 (ATG10) is a ubiquitous 28kDa member of the ATG10 family protein. ATG10 acts as an E2-like enzyme, catalyzes the transfer of ATG12 to ATG5 during in the initial stages of autophagesome formation. The heterodimer of ATG5 and ATG12 subsequntly associates non-covalently with an ATG16 multimer to generate an antophagosome. ATG10 plays a role in the conjugation of ATG12 to ATG5 by interaction with MAP1LC3A. In addition, ATG10 can diretly interact with ATG5 or A...
TMPJ-01321 MAP1LC3B Protein, Human, Recombinant Human E. coli
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in the MAP1LC3 subfamily (others include MAP1LC3A, MAP1LC3C, and MAP1LC3B2). It is moat abundantly expressed in heart, brain, skeletal muscle and testis. LMAP1LC3B is a subunit of neuronal microtubule and functions in formation of autophagosomal vacuoles (autophagosomes). It associat...
TMPJ-01354 ATG3 Protein, Human, Recombinant Human E. coli
Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its mouse and rat orthologs. It is widely expressed and has highly levels in heart, skeletal muscle, kidney, liver and placenta. As an E2-like enzyme, involves in autophagy and mitochondrial homeostasis. ATG3 catalyzes the conjugation of ATG8-like proteins to PE which is essential fo...
TMPY-02431 BCL-XL Protein, Human, Recombinant (His) Human E. coli
B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibit apoptosis. Antiapoptotic members such as Bcl-2 and Bcl-xL prevent PCD in response to a wide variety of stimuli to take part in cancer survival. Conversely, proapoptotic proteins, exemplified by Bax and Bak, can accelerate death and in some instances are sufficient to cause apop...
TMPY-00431 BMP4 Protein, Mouse, Recombinant (rFc) Mouse HEK293
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated...
TMPY-06842 BMP4 Protein, Human, Recombinant (E399D) Human E. coli
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated...
TMPY-03268 GABARAPL1 Protein, Human, Recombinant (His) Human E. coli
ATG8, also known as GABARAPL1, is a ubiquitin-like protein that has a crystal structure. ATG8 consists of a 5-stranded β-sheet, which is enclosed by two α-helices at one side and one α-helix at the other side and exhibits a conserved GABARAP domain. It functions in the formation of autophagosomal membranes. The transient conjugation of ATG8 to the autophagosomal membrane through a ubiquitin-like conjugation system is essential for autophagy in eukaryotes. Autophagy is induced upon nutrient deple...
TMPY-00473 NRBF2 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tissues. NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagy/autophagy class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15, and PIK3C3/Vps34. NRBF2 is a critical molecular switch of PtdIns3K and a...
TMPY-05160 PFKP Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
PFKP plays a critical role in cell proliferation in breast cancer cells. PFKP is necessary for starvation-mediated autophagy, glycolysis, and EMT, thereby promoting the malignant progression of OSCC. The Snail-PFKP axis plays an important role in cancer cell survival via regulation of glucose flux between glycolysis and PPP.
TMPY-02564 BCL-XL Protein, Mouse, Recombinant (aa 1-212, His) Mouse E. coli
B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibit apoptosis. Antiapoptotic members such as Bcl-2 and Bcl-xL prevent PCD in response to a wide variety of stimuli to take part in cancer survival. Conversely, proapoptotic proteins, exemplified by Bax and Bak, can accelerate death and in some instances are sufficient to cause apop...
TMPY-00587 GABARAP Protein, Human, Recombinant (His & MBP) Human E. coli
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in vivo by delaying cell death and its associated immune-related response. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases. GABARAPs as the first known direct interaction partners of Nef that are essential...
TMPY-03416 TNFAIP8 Protein, Human, Recombinant (His) Human E. coli
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom...
TMPY-02572 TXNDC17 Protein, Human, Recombinant Human E. coli
Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein family that lacks activity with classical Trx1 substrates. TXNDC17 is a novel 14-kDa disulfide reductase of the TXN (thioredoxin) family. TXNDC17 is involved in the TNF (tumor necrosis factor) signaling pathway. Moreover, TXNDC17 plays an important role in Taxol resistance via enha...
TMPJ-00924 Decorin Protein, Mouse, Recombinant (His) Mouse Human Cells
Decorin, also known as PG40 and DCN, is a member of the class I family of small leucine-rich proteoglycans (SLRPs) that is expressed in the stroma of various forms of cancer and has been recently proposed to act as a guardian from the matrix. Mature human Decorin contains 12 tandem LRR and shares 80% and 78% aa sequence identity with mouse and rat Decorin, respectively. Decorin embraces numerous functions including: regulation of collagen fibrillogenesis, hepatic carcinogenesis, fetal membrane a...
TMPY-03749 LC3B Protein, Human, Recombinant (His) Human E. coli
MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. LC3B is a member of the MAP1 LC3 family. It is most abundantly expressed in the heart, brain, skeletal muscle, and testis. LC3B is a subunit of the neuronal microtubule and functions in the formation of autophagosomal...
TMPJ-00015 GABARAP Protein, Human, Recombinant (His & hFc) Human E. coli
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of ...
TMPJ-00016 GABARAP Protein, Human, Recombinant (GST) Human E. coli
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of ...

Recombinant Proteins

ELAPOR1 Protein, Human, Recombinant (His)
TMPJ-01192
Species: Human
Source: Human Cells
ATG5 Protein, Human, Recombinant
TMPJ-01329
Species: Human
Source: E. coli
ATG4A Protein, Human, Recombinant (His)
TMPJ-01250
Species: Human
Source: E. coli
ATG10 Protein, Human, Recombinant (His, T7)
TMPJ-01327
Species: Human
Source: E. coli
MAP1LC3B Protein, Human, Recombinant
TMPJ-01321
Species: Human
Source: E. coli
ATG3 Protein, Human, Recombinant
TMPJ-01354
Species: Human
Source: E. coli
BCL-XL Protein, Human, Recombinant (His)
TMPY-02431
Species: Human
Source: E. coli
BMP4 Protein, Mouse, Recombinant (rFc)
TMPY-00431
Species: Mouse
Source: HEK293
BMP4 Protein, Human, Recombinant (E399D)
TMPY-06842
Species: Human
Source: E. coli
GABARAPL1 Protein, Human, Recombinant (His)
TMPY-03268
Species: Human
Source: E. coli
NRBF2 Protein, Human, Recombinant (His & GST)
TMPY-00473
Species: Human
Source: Baculovirus-Insect Cells
PFKP Protein, Human, Recombinant (His & GST)
TMPY-05160
Species: Human
Source: Baculovirus-Insect Cells
BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)
TMPY-02564
Species: Mouse
Source: E. coli
GABARAP Protein, Human, Recombinant (His & MBP)
TMPY-00587
Species: Human
Source: E. coli
TNFAIP8 Protein, Human, Recombinant (His)
TMPY-03416
Species: Human
Source: E. coli
TXNDC17 Protein, Human, Recombinant
TMPY-02572
Species: Human
Source: E. coli
Decorin Protein, Mouse, Recombinant (His)
TMPJ-00924
Species: Mouse
Source: Human Cells
LC3B Protein, Human, Recombinant (His)
TMPY-03749
Species: Human
Source: E. coli
GABARAP Protein, Human, Recombinant (His & hFc)
TMPJ-00015
Species: Human
Source: E. coli
GABARAP Protein, Human, Recombinant (GST)
TMPJ-00016
Species: Human
Source: E. coli
TargetMol