Shopping Cart

Your shopping cart is currently empty

Gly-β-MCA

Name: Gly-β-MCA
Brand: TargetMol
SKU: T11426
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T11426Cas No. 66225-78-3

Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.

Gly-β-MCA

😃Good

Catalog No. T11426Cas No. 66225-78-3

Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:≥98.0%

Appearance:Solid

Color:White

Resource Download

COA HNMR MS

Product Introduction

Bioactivity

Description	Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.
In vitro	Gly-β-MCA is an effective intestinal selective farnesoid X receptor (FXR) inhibitor, belonging to the bile acids class[1]. Gly-β-MCA (Gly-MCA) exhibits resistance to hydrolysis by BSH (bile salt hydrolase)[1].
In vivo	Gly-β-MCA (Gly-MCA, oral administration, 10 and 50 mg/kg) can prevent and treat diet-induced and genetic obesity, insulin resistance, and hepatic steatosis in mice, without causing systemic, hepatic, or intestinal toxicity[1].Gly-MCA does not increase fecal LCN-2 levels, indicating that Gly-MCA does not induce intestinal inflammation[1].

Chemical Properties

Molecular Weight	465.62
Formula	C₂₆H₄₃NO₆
Cas No.	66225-78-3
Smiles	C[C@H](CCC(=O)NCC(O)=O)C1CCC2C3[C@@H](O)[C@@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C
Relative Density.	1.213 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <0.1 mg/mL (Insoluble)

DMSO: 50 mg/mL (107.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1477 mL	10.7384 mL	21.4767 mL	107.3837 mL
5 mM	0.4295 mL	2.1477 mL	4.2953 mL	21.4767 mL
10 mM	0.2148 mL	1.0738 mL	2.1477 mL	10.7384 mL
20 mM	0.1074 mL	0.5369 mL	1.0738 mL	5.3692 mL
50 mM	0.0430 mL	0.2148 mL	0.4295 mL	2.1477 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0738 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc