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Gly-β-MCA

Name: Gly-β-MCA
Brand: TargetMol
SKU: T11426
Rating: 4.5 (1 reviews)

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Catalog No. T11426Cas No. 66225-78-3

Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.

Gly-β-MCA

😃Good

Catalog No. T11426Cas No. 66225-78-3

Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.
In vitro	Gly-β-MCA is an effective intestinal selective farnesoid X receptor (FXR) inhibitor, belonging to the bile acids class[1]. Gly-β-MCA (Gly-MCA) exhibits resistance to hydrolysis by BSH (bile salt hydrolase)[1].
In vivo	Gly-β-MCA (Gly-MCA, oral administration, 10 and 50 mg/kg) can prevent and treat diet-induced and genetic obesity, insulin resistance, and hepatic steatosis in mice, without causing systemic, hepatic, or intestinal toxicity[1].Gly-MCA does not increase fecal LCN-2 levels, indicating that Gly-MCA does not induce intestinal inflammation[1].

Chemical Properties

Molecular Weight	465.62
Formula	C₂₆H₄₃NO₆
Cas No.	66225-78-3
Smiles	C[C@H](CCC(=O)NCC(O)=O)C1CCC2C3[C@@H](O)[C@@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C
Relative Density.	1.213 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <0.1 mg/mL (Insoluble)

DMSO: 50 mg/mL (76.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1477 mL	10.7384 mL	21.4767 mL	107.3837 mL
5 mM	0.4295 mL	2.1477 mL	4.2953 mL	21.4767 mL
10 mM	0.2148 mL	1.0738 mL	2.1477 mL	10.7384 mL
20 mM	0.1074 mL	0.5369 mL	1.0738 mL	5.3692 mL
50 mM	0.0430 mL	0.2148 mL	0.4295 mL	2.1477 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc