antigen

SV40 large T antigen NLS, originating from Large T antigen residue 47 to 55, facilitates protein import into the cell nucleus. This peptide is specifically generated from Large T antigen residue 47 to 55.

Carcinoembryonic antigen peptide 1 (CEA peptide) is a Carcinoembryonic Antigen (CEA) derived peptide, of which sequen is YLSGANLNL. CEA is a broad-spectrum tumour marker, a glycoprotein produced by colorectal cancer tissues, which acts as an antigen to elicit an immune response.

MAGE-3 Antigen (167-176) (human) is an eight-amino-acid polypeptide epitope for HLA-B44 molecules, encoded by the melanoma antigen gene (MAGE) [1].

Mage-1 Antigen (161-169), human is a polypeptide molecule with the sequence EADPTGHSY.

SV40 large T antigen NLS acetate is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.

Large T antigen - rhesus polyomavirus 560-568 has a peptide sequence of Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile. T antigen is required for viral DNA replication, transcription, and virion assembly.

MHC class II antigen (45-57) [Homo sapiens] is a peptide with the sequence H2N-Asp-Leu-Asp-Lys-Lys-Glu-Thr-Val-Trp-His-Leu-Glu- Glu-OH, MW= 1868.07. MHC (major histocompatibility complex) class II molecules are found only on antigen-presenting cells and l

SSA antigenic peptide represents the antigenic fragment associated with Sjögren's syndrome-related antigen A (SSA) [1].

MOG (35-55) mouse, rat is a minor component of the central nervous system myelin with high brain specificity and strong immunogenicity. It can induce T and B cell responses, trigger relapsing-remitting neurological disorders with plaque-like demyelination, and is commonly used for inducing experimental autoimmune encephalomyelitis (EAE) models.

HPV16 E7 (86-93) acetate is a derived peptide of human leukocyte antigen A2.1 restricted HPV16 E7 with immunogenic property in cervical carcinomas.

NLS PKKKRKV acetate is a peptide derived from the 40 tumor antigen of the great ape virus (SV40 big T antigen), which is a method to enhance the nuclear portal in the research field of gene transfer.

Alisporivir (Debio-025) is a cyclophilin A inhibitor that disrupts the interaction between CypA and NS5A. It exhibits anti-hepatitis C virus (HCV) activity in vivo and in vitro, inhibits the replication of MERS and SARS coronaviruses, and promotes antigen-specific CD8(+) T cell activation.

CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.

Reltecimod, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.

STh, also known as Escherichia coli heat-stable toxin, is a 19 amino acid polypeptide containing three disulfide bridges. It serves as an antigen of significance in the quest for a comprehensive enterotoxigenic Escherichia coli (ETEC) vaccine.

LLO (91-99), also known as Listeriolysin O (91-99), is a class I MHC-restricted T-cell epitope derived from listeriolysin (LLO), an exotoxin. It plays a vital role as an antigen in the induction of T-cell mediated immunity in vivo.

OVA 55-62 is a truncated peptide derived from the ovalbumin (OVA) antigen, specifically designed to bind to the H2-Kb mouse major histocompatibility complex (MHC) class I molecule.

MAGE-3 (271-279) is a peptide consisting of 271-279 amino acid residues derived from melanoma antigens encoded by the MAGE-3 gene. It is specifically recognized by cytolytic T lymphocytes (CTLs) and binds to the human leukocyte antigen (HLA)-A2 molecule. MAGE-3 is highly expressed in various human tumor types, such as malignant melanoma, but not in normal tissues, except for the testis and placenta.

Gp100 (25-33) corresponds to residues 25 to 33 of the mouse self/tumor antigen glycoprotein (mgp100), which is an enzyme responsible for pigment synthesis. This epitope fragment is found in both normal melanocytes and melanoma cells.

GAD65 (206-220) is a synthetic peptide derived from glutamic acid decarboxylase (GAD) 65, specifically corresponding to residues 180-188. It is known that GAD65 interacts with I-Ag7 MHC class II molecules and is a significant pancreatic antigen that self-reactive T cells target in type I diabetes mellitus.

HPV16 E7 (86-93) TFA, a peptide derived from HPV16 E7, is restricted by human leukocyte antigen (HLA)-A2.1 and exhibits immunogenic properties in cervical carcinomas [1] [2].

CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a receptor on endothelial cells for clostridium perfringens beta-Toxin (CPB). It also functions as an ER-MP12 antigen and connects mechanical stress, metabolism, and inflammation. The CD31 peptide promotes phosphorylation of CD31 ITIM 686 and SHP2, thereby inhibiting TCR-induced T-cell activation [1]-[5].

CD31 TFA, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), functions as the specific receptor for Clostridium perfringens beta-Toxin (CPB) in endothelial cells. It is recognized as an ER-MP12 antigen and plays a pivotal role in connecting mechanical stress, metabolism, and inflammation. Additionally, the CD31 TFA peptide facilitates the phosphorylation of CD31 ITIM 686 and SHP2, further inhibiting TCR-induced T-cell activation [1]-[5].

Hepatitis B Virus Pre-S Region (120-145) is a preS2 peptide that effectively blocks the attachment of single-chain Fv fragment (scFv) or IgG to recombinant Hepatitis B surface antigen (r-HBsAg) [1].