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Apoptosis

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay.
Cat. No. Product name CAS No. Purity Chemical Structure
T35528 TD52 1798328-24-1 99.5%
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
T8199 (±)-α-Bisabolol 515-69-5 99.44%
(±)-α-Bisabolol isa sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, antiirritating,...
T14378 AZD5582 1258392-53-8 98.83%
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.
TQ0215 Salinomycin sodium salt 55721-31-8 98%
Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
TN3910 Ecdysone 3604-87-3 100%
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D a...
T1947 BS-181 1092443-52-1
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
T3340 SCR7 1533426-72-0
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
T3081L EPZ004777 hydrochloride 1380316-03-9
EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T4114 Diffractaic Acid 436-32-8
Diffractaic Acid can inhibit LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with activity value of 8 μM.
T4134L OTS514 1338540-63-8
OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell l...
T6724 Voreloxin 175414-77-4 98%
Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
TN1694 Gliotoxin 67-99-2 98%
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
T77713 BTM-3566 2228857-70-1 98%
BTM-3566 activates the ISR through the mitochondrial protease OMA1.BTM-3566 induces apoptosis in cancer cells. BTM-3566 overactivates the mitochondrial ISR to st...
T3S0541 Curzerene 17910-09-7 98%
Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apopt...
TN5280 (-)-Zeylenol 78804-17-8 98%
(-)-Zeylenol is a natural product derived from the stems of the Uvaria grandiflora, showing anti-inflammatory, antifeedant and antitumor biological activity, act...
TN2091 Polygalacin D 66663-91-0 98%
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS...
T64533 Ceramide (Egg, Chicken) 477243-06-4 98%
Ceramide (Egg, Chicken) plays a major role in the anabolic and catabolic pathways of sphingolipid. Ceramide (Egg, Chicken) stimulates many cell differentiation, ...
TN6097 Girinimbine 23095-44-5 98%
Girinimbine is a carbazole alkaloid isolated from the plants M. koenigii, M. koenigii and Murraya koenigii.Girinimbine has a wide range of biological effects, in...
T19886 Cirsilineol 41365-32-6 98%
Cirsilineol is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selective...
TN3616 Cedrelone 1254-85-9 98%
Cedrelone is a citrulline analog and a phenazine biosynthesis-like domain protein (PBLD) activator.Cedrelone induces apoptosis in cancer cells.Cedrelone is a ver...
TD52
T35528
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
(±)-α-Bisabolol
T8199
(±)-α-Bisabolol isa sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, antiirritating,...
AZD5582
T14378
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.
Salinomycin sodium salt
TQ0215
Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
Ecdysone
TN3910
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D a...
BS-181
T1947
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
SCR7
T3340
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
EPZ004777 hydrochloride
T3081L
EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
Diffractaic Acid
T4114
Diffractaic Acid can inhibit LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with activity value of 8 μM.
OTS514
T4134L
OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell l...
Voreloxin
T6724
Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
Gliotoxin
TN1694
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
BTM-3566
T77713
BTM-3566 activates the ISR through the mitochondrial protease OMA1.BTM-3566 induces apoptosis in cancer cells. BTM-3566 overactivates the mitochondrial ISR to st...
Curzerene
T3S0541
Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apopt...
(-)-Zeylenol
TN5280
(-)-Zeylenol is a natural product derived from the stems of the Uvaria grandiflora, showing anti-inflammatory, antifeedant and antitumor biological activity, act...
Polygalacin D
TN2091
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS...
Ceramide (Egg, Chicken)
T64533
Ceramide (Egg, Chicken) plays a major role in the anabolic and catabolic pathways of sphingolipid. Ceramide (Egg, Chicken) stimulates many cell differentiation, ...
Girinimbine
TN6097
Girinimbine is a carbazole alkaloid isolated from the plants M. koenigii, M. koenigii and Murraya koenigii.Girinimbine has a wide range of biological effects, in...
Cirsilineol
T19886
Cirsilineol is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selective...
Cedrelone
TN3616
Cedrelone is a citrulline analog and a phenazine biosynthesis-like domain protein (PBLD) activator.Cedrelone induces apoptosis in cancer cells.Cedrelone is a ver...
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