| T6303L |
CCT128930 hydrochloride |
CCT128930 hydrochloride is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophag...
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| T5S1000 |
Sophoraflavanone G |
Sophoraflavanone G (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
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| TN1065 |
Hirsutine |
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and ...
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| TN1038 |
Galgravin |
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid...
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| TN1019 |
Beta-mangostin |
Beta-Mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-Mangostin (β-Mangostin) present in Cratoxylum arboresc...
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| TP1072 |
Valinomycin |
Valinomycin is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Se...
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| T7845 |
BTZO-1 |
BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
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| T8297 |
Gomisin N |
Gomisin N, isolated from Schisandra chinensis, produces beneficial sedative and hypnotic bioactivity. It has the potential for use in the treatment of allergy an...
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| T2S1008 |
Oxysophoridine |
Oxysophoridine has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective...
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| TN1094 |
Ginsenoside Rg6 |
Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cells
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| T2S2382 |
3'-Hydroxypterostilbene |
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for ...
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| T4S1540 |
Myrislignan |
Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a ...
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| T3849 |
Kinsenoside;(+)-Kinsenoside |
Kinsenoside shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury ...
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| T8030 |
Ethyl pyruvate |
Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, a...
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| T7791 |
Iberdomide |
Iberdomide is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
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| TQ0317 |
R1530 |
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.
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| TQ0302 |
Thapsigargin |
Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.
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| TN1087 |
Deoxypodophyllotoxin |
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammat...
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| TN1153 |
Polyporenic acid C |
Polyporenic acid C shows inhibitory activity against human collagenase.
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| TQ0060 |
LY2857785 |
LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).
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| TN1856 |
Leachianone A |
Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
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| TN2215 |
Sodium taurochenodeoxycholate |
Sodium taurochenodeoxycholate is one of the main bioactive substances of animals' bile acid. Sodium taurochenodeoxycholate induces apoptosis and shows obvious a...
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| TN2097 |
Pomolic acid |
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
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| TN2091 |
Polygalacin D |
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS...
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| TN2069 |
Picrocrocin |
Picrocrocin is a natural product
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| TN1891 |
Lupiwighteone |
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
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| TN1877 |
Lonicerin |
Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albic...
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| TN1828 |
Kahweol |
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
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| TN1237 |
3,4-Dihydroxy-5-methoxybenzoic acid |
3,4-Dihydroxy-5-methoxybenzoic acid reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection again...
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| TN1684 |
Ginsenoside F5 |
Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
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| TN1684 |
Ginsenoside F5 |
Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
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| TN1620 |
Eriocalyxin B |
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
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| TN1586 |
Dihydrorotenone |
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
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| TN1560 |
Dehydroeffusol |
Dehydroeffusol possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively in...
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| TN1421 |
Bacopaside II |
Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.
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| TN1417 |
Azadirachtin |
Azadirachtin has antifungal activity, used as an insecticide.
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| TQ0089 |
Juglanin |
Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.
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| T7337 |
Kinetin riboside |
Kinetin riboside can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells(IC50 of 2.5 μM)
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| TN2269 |
Tetramethylcurcumin |
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also ...
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| T2829 |
Isoalantolactone |
Isoalantolactone, isolated from Inula spp., can inhibit the growth of several types of Y cells.
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| T3916 |
Ginsenoside F2 |
Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic ...
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| T3488 |
Tectorigenin |
Tectorigenin is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation ...
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| T3771 |
Methyl protodioscin |
Methyl protodioscin potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl pro...
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| T3314 |
Perillyl alcohol |
Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and gerany...
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| T3895 |
Polyphyllin I |
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
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| T3373 |
Columbianadin |
Columbianadin, one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious phar...
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| T2808 |
Bilobalide |
Bilobalide, a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.
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| T3752 |
4-Hydroxybenzyl alcohol |
4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expressi...
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| T2799 |
(20S)-Protopanaxadiol |
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
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| T3908 |
10-Gingerol |
10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, p38 MAPK (p38), c-Jun N-terminal kinase ...
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| T3405 |
6-Gingerol |
6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bo...
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| T3008 |
2-Methoxynaphthoquinone |
MNQ induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated t...
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| T3759 |
3,4-Dimethoxycinnamic acid |
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts an...
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| T6742 |
2-Deoxy-D-glucose |
2-Deoxy-D-glucose is an analog of glucose, which is a glycolytic inhibitor with antiviral activity.
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| T3796 |
Betulinaldehyde |
Betulinaldehyde has the inhibition of Saccharomyces sp and alpha-glucosidase. Betulinaldehyde induces apoptosis in mouse B16 2F2 cells. Betulinaldehyde has anti-...
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|
| T3752 |
4-Hydroxybenzyl alcohol |
4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expressi...
|
|
| T3902 |
Atractylenolide III |
Atractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential...
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|
| T7174 |
Urolithin A |
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
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|
| T5132 |
9-dihydro-13-acetylbaccatin III |
9-Dihydro-13-acetylbaccatin III is an apoptosis inducer. It shows cytotoxicity against the MCF7 cell line and drug-resistant cell line MCF7-ADR.
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| T5753 |
Flavokawain C |
Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the tre...
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| T5793 |
Britannin |
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
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| T5822 |
5-Benzylidene-3-ethyl rhodanine |
5-Benzylidene-3-ethyl rhodanine(BTR-1) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.
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| T5780 |
HYPOCRELLIN B |
HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer c...
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| T2S1396 |
3-O-Acetyloleanolic acid |
3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1...
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|
| T5514 |
Epibrassinolide |
Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, is a natural brassinosteroid (BR) derivative, is a plant regulator with a simila...
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| T4588 |
Glycochenodeoxycholic Acid |
Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxych...
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| T6664 |
SecinH3 |
SecinH3 is selective cytohesin inhibitor.
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| T4588 |
Glycochenodeoxycholic Acid |
Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxych...
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|
| T2S0618 |
β-Elemonic Acid |
1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antica...
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| T5S0761 |
Nitidine chloride |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
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| T4241 |
Rubiadin |
Rubiadin possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner.
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| T4004 |
Concanavalin A |
Concanavalin A is a plant lectin that is a T cell mitogen. It induces apoptosis in human fibroblasts.
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| T6S1780 |
Protosappanin B |
1. Protosappanin B significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappa...
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|
| T1882 |
Methylisoindigotin |
Meisoindigo is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
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|
| TN2225 |
Soyasapogenol B |
Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
|
|
| T12189 |
NBDHEX |
NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
|
|
| T9582 |
CLEFMA |
CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
|
|
| T22776 |
Ezatiostat hydrochloride |
Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatme...
|
|
| T13647 |
Dextran sulfate sodium salt (MW 16000-24000) |
Dextran sulfate sodium salt (MW 16000-24000) is an anhydrous glucose polymer with a molecular weight range of 16000-24000. The sodium salt inhibits the replicati...
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| T20792 |
W-7 HCl |
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
|
|
| T19831 |
Sodium Oxamate |
Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis t...
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|
| T8716 |
Physalin F |
Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immun...
|
|
| T8678 |
Naphthazarin |
Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerizatio...
|
|
| T23450 |
TCS PrP Inhibitor 13 |
TCS PrP Inhibitor 13 is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.
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|
| TL0016 |
Sulforaphene |
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
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|
| T8333 |
Aurintricarboxylic acid |
Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
|
|
| T7190 |
Actein |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
|
|
| T6740 |
Bafilomycin A1 |
Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuola...
|
|
| T2S1975 |
Ponicidin |
Ponicidin is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicid...
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| T22456 |
Voreloxin hydrochloride |
Voreloxin hydrochloride is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.
|
|
| T22358 |
Etalocib |
Etalocib is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotr...
|
|
| T16996 |
TAS6417 |
TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
|
|
| T16977 |
Talampanel |
Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neu...
|
|
| T19676 |
Tributyrin |
Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses t...
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|
| T19857 |
Glyphosate |
Glyphosate is an herbicide. It also is a possible carcinogen to humans.
|
|
| T16961 |
Supinoxin |
Supinoxin is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and in...
|
|
| T9104 |
TJ191 |
TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
|
|
| TN7041 |
(-)-Epipodophyllotoxin |
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Ep...
|
|
| T9503 |
PHYTOSPHINGOSINE |
Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and trans...
|
|
| T9465 |
ZZW-115 hydrochloride |
ZZW-115 hydrochloride inhibits the activity of NUPR1.
|
|
| TQ0318L |
ARRY 520 hydrochloride |
ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative acti...
|
|
| T10463L |
Bax inhibitor peptide V5 acetate |
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
|
|
| TN6735 |
Bigelovin |
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR p...
|
|
| T9102 |
WM-3835 |
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell prolifera...
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|
| T19823 |
Tebufenozide |
Tebufenozide is a novel nonsteroidal ecdysone agonist. It shows good efficacy and playing an increasingly important role in the control of Lepidopteran pests.
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|
| T26357 |
Pitstop 2 |
Pitstop 2 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential ...
|
|
| T26288 |
Clovamide |
Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a poten...
|
|
| T9014 |
SKI-178 |
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsi...
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|
| T24166 |
Inecalcitol |
Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.
|
|
| T8934 |
(6R)-FR054 |
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.
|
|
| T21876 |
DC_AC50 |
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemothe...
|
|
| T8762 |
SW-106065 |
SW-106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant periphe...
|
|
| T16974 |
TAK-243 |
TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as ...
|
|
| T8478 |
SC-43 |
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and ...
|
|
| T12240 |
Nor-NOHA acetate |
nor-NOHA acetate is a reversible inhibitor of arginase, with anti-leukemic activity, effective in endothelial dysfunction, immunosuppression, and metabolism.
|
|
| T14298 |
Rimiducid |
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
|
|
| T8492 |
BO-264 |
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).
|
|
| T10549 |
Bisindolylmaleimide VIII acetate |
Bisindolylmaleimide VIII acetate is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-...
|
|
| T10460 |
Batabulin |
Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization....
|
|
| T11366 |
Garcinol |
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and ant...
|
|
| T11139 |
(E/Z)-BCI |
(E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB p...
|
|
| T10831L |
Cl-amidine hydrochloride |
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in ca...
|
|
| T14177 |
Alexidine dihydrochloride |
Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent t...
|
|
| T13950 |
UC-514321 |
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, wi...
|
|
| T17350 |
ACBI1 |
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
|
|
| T14125 |
Adarotene |
Adarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor...
|
|
| T13665 |
DT2216 |
DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extremel...
|
|
| T12516 |
Polyinosinic-polycytidylic acid sodium |
Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
|
|
| T12454 |
PI-273 |
PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells
|
|
| T13818 |
Phytohemagglutinin |
Phytohemagglutinin is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tum...
|
|
| T13815 |
Penicillic acid |
Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.Penicillic acid is a polyketide mycotoxin produced by several spec...
|
|
| T11600 |
IBR2 |
IBR2 is a potent and specific RAD51 inhibitor that inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates prote...
|
|
| T13336 |
VTP50469 |
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
|
|
| T16791 |
Rottlerin |
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,...
|
|
| T16363 |
NVP-2 |
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50...
|
|
| T16750 |
Rigosertib |
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
|
|
| T16745 |
Rhosin hydrochloride |
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
|
|
| T11826 |
LCH-7749944 |
LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apopto...
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| T11820 |
LAT1-IN-1 |
LAT1-IN-1 (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. i...
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| T16684 |
Puromycin aminonucleoside |
Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
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| T16522 |
Phenoxodiol |
Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and s...
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| T8531 |
M-3M3FBS |
m-3M3FBS is a phospholipase C (PLC) activator.
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| T16324 |
Nimbolide |
Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis t...
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| T15433 |
GSK2795039 |
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
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| T16163 |
MV1 |
MV1 is an IAP antagonist. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins.
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| T16087 |
Quiflapon |
Quiflapon causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) ...
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| T16075 |
Minerval |
Minerval is a fatty acid amide hydrolase inhibitor with anti-tumor effect. It binds to the plasma membrane and alters lipid organization.
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| T16016 |
Maytansinol |
Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.
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| T13476 |
β-Elemene |
β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.
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| T13416 |
ZX-29 |
ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...
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| T8464 |
RA-9 |
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
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| T2733 |
Sarsasapogenin |
Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing pl...
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