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Apoptosis Apoptosis

Apoptosis

Cat No. product name
T6303L CCT128930 hydrochloride CCT128930 hydrochloride is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophag...
T5S1000 Sophoraflavanone G Sophoraflavanone G (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
TN1065 Hirsutine Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and ...
TN1038 Galgravin Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid...
TN1019 Beta-mangostin Beta-Mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-Mangostin (β-Mangostin) present in Cratoxylum arboresc...
TP1072 Valinomycin Valinomycin is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Se...
T7845 BTZO-1 BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
T8297 Gomisin N Gomisin N, isolated from Schisandra chinensis, produces beneficial sedative and hypnotic bioactivity. It has the potential for use in the treatment of allergy an...
T2S1008 Oxysophoridine Oxysophoridine has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective...
TN1094 Ginsenoside Rg6 Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cells
T2S2382 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for ...
T4S1540 Myrislignan Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a ...
T3849 Kinsenoside;(+)-Kinsenoside Kinsenoside shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury ...
T8030 Ethyl pyruvate Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, a...
T7791 Iberdomide Iberdomide is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
TQ0317 R1530 R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.
TQ0302 Thapsigargin Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.
TN1087 Deoxypodophyllotoxin Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammat...
TN1153 Polyporenic acid C Polyporenic acid C shows inhibitory activity against human collagenase.
TQ0060 LY2857785 LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).
TN1856 Leachianone A Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
TN2215 Sodium taurochenodeoxycholate Sodium taurochenodeoxycholate is one of the main bioactive substances of animals' bile acid. Sodium taurochenodeoxycholate induces apoptosis and shows obvious a...
TN2097 Pomolic acid Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
TN2091 Polygalacin D Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS...
TN2069 Picrocrocin Picrocrocin is a natural product
TN1891 Lupiwighteone Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
TN1877 Lonicerin Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albic...
TN1828 Kahweol Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
TN1237 3,4-Dihydroxy-5-methoxybenzoic acid 3,4-Dihydroxy-5-methoxybenzoic acid reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection again...
TN1684 Ginsenoside F5 Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
TN1684 Ginsenoside F5 Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
TN1620 Eriocalyxin B Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
TN1586 Dihydrorotenone Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
TN1560 Dehydroeffusol Dehydroeffusol possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively in...
TN1421 Bacopaside II Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.
TN1417 Azadirachtin Azadirachtin has antifungal activity, used as an insecticide.
TQ0089 Juglanin Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.
T7337 Kinetin riboside Kinetin riboside can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells(IC50 of 2.5 μM)
TN2269 Tetramethylcurcumin Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also ...
T2829 Isoalantolactone Isoalantolactone, isolated from Inula spp., can inhibit the growth of several types of Y cells.
T3916 Ginsenoside F2 Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic ...
T3488 Tectorigenin Tectorigenin is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation ...
T3771 Methyl protodioscin Methyl protodioscin potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl pro...
T3314 Perillyl alcohol Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and gerany...
T3895 Polyphyllin I Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
T3373 Columbianadin Columbianadin, one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious phar...
T2808 Bilobalide Bilobalide, a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.
T3752 4-Hydroxybenzyl alcohol 4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expressi...
T2799 (20S)-Protopanaxadiol (20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
T3908 10-Gingerol 10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, p38 MAPK (p38), c-Jun N-terminal kinase ...
T3405 6-Gingerol 6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bo...
T3008 2-Methoxynaphthoquinone MNQ induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated t...
T3759 3,4-Dimethoxycinnamic acid 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts an...
T6742 2-Deoxy-D-glucose 2-Deoxy-D-glucose is an analog of glucose, which is a glycolytic inhibitor with antiviral activity.
T3796 Betulinaldehyde Betulinaldehyde has the inhibition of Saccharomyces sp and alpha-glucosidase. Betulinaldehyde induces apoptosis in mouse B16 2F2 cells. Betulinaldehyde has anti-...
T3752 4-Hydroxybenzyl alcohol 4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expressi...
T3902 Atractylenolide III Atractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential...
T7174 Urolithin A Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T5132 9-dihydro-13-acetylbaccatin III 9-Dihydro-13-acetylbaccatin III is an apoptosis inducer. It shows cytotoxicity against the MCF7 cell line and drug-resistant cell line MCF7-ADR.
T5753 Flavokawain C Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the tre...
T5793 Britannin Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
T5822 5-Benzylidene-3-ethyl rhodanine 5-Benzylidene-3-ethyl rhodanine(BTR-1) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.
T5780 HYPOCRELLIN B HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer c...
T2S1396 3-​O-​Acetyloleanolic acid 3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1...
T5514 Epibrassinolide Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, is a natural brassinosteroid (BR) derivative, is a plant regulator with a simila...
T4588 Glycochenodeoxycholic Acid Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxych...
T6664 SecinH3 SecinH3 is selective cytohesin inhibitor.
T4588 Glycochenodeoxycholic Acid Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxych...
T2S0618 β-Elemonic Acid 1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antica...
T5S0761 Nitidine chloride 1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T4241 Rubiadin Rubiadin possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner.
T4004 Concanavalin A Concanavalin A is a plant lectin that is a T cell mitogen. It induces apoptosis in human fibroblasts.
T6S1780 Protosappanin B 1. Protosappanin B significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappa...
T1882 Methylisoindigotin Meisoindigo is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
TN2225 Soyasapogenol B Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
T12189 NBDHEX NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
T9582 CLEFMA CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
T22776 Ezatiostat hydrochloride Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatme...
T13647 Dextran sulfate sodium salt (MW 16000-24000) Dextran sulfate sodium salt (MW 16000-24000) is an anhydrous glucose polymer with a molecular weight range of 16000-24000. The sodium salt inhibits the replicati...
T20792 W-7 HCl W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
T19831 Sodium Oxamate Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis t...
T8716 Physalin F Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immun...
T8678 Naphthazarin Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerizatio...
T23450 TCS PrP Inhibitor 13 TCS PrP Inhibitor 13 is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.
TL0016 Sulforaphene Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
T8333 Aurintricarboxylic acid Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
T7190 Actein Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
T6740 Bafilomycin A1 Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuola...
T2S1975 Ponicidin Ponicidin is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicid...
T22456 Voreloxin hydrochloride Voreloxin hydrochloride is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.
T22358 Etalocib Etalocib is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotr...
T16996 TAS6417 TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
T16977 Talampanel Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neu...
T19676 Tributyrin Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses t...
T19857 Glyphosate Glyphosate is an herbicide. It also is a possible carcinogen to humans.
T16961 Supinoxin Supinoxin is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and in...
T9104 TJ191 TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
TN7041 (-)-Epipodophyllotoxin (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Ep...
T9503 PHYTOSPHINGOSINE Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and trans...
T9465 ZZW-115 hydrochloride ZZW-115 hydrochloride inhibits the activity of NUPR1.
TQ0318L ARRY 520 hydrochloride ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative acti...
T10463L Bax inhibitor peptide V5 acetate Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
TN6735 Bigelovin Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR p...
T9102 WM-3835 WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell prolifera...
T19823 Tebufenozide Tebufenozide is a novel nonsteroidal ecdysone agonist. It shows good efficacy and playing an increasingly important role in the control of Lepidopteran pests.
T26357 Pitstop 2 Pitstop 2 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential ...
T26288 Clovamide Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a poten...
T9014 SKI-178 SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsi...
T24166 Inecalcitol Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.
T8934 (6R)-FR054 FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.
T21876 DC_AC50 DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemothe...
T8762 SW-106065 SW-106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant periphe...
T16974 TAK-243 TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as ...
T8478 SC-43 SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and ...
T12240 Nor-NOHA acetate nor-NOHA acetate is a reversible inhibitor of arginase, with anti-leukemic activity, effective in endothelial dysfunction, immunosuppression, and metabolism.
T14298 Rimiducid Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
T8492 BO-264 BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).
T10549 Bisindolylmaleimide VIII acetate Bisindolylmaleimide VIII acetate is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-...
T10460 Batabulin Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization....
T11366 Garcinol Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and ant...
T11139 (E/Z)-BCI (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB p...
T10831L Cl-amidine hydrochloride Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in ca...
T14177 Alexidine dihydrochloride Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent t...
T13950 UC-514321 UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, wi...
T17350 ACBI1 ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
T14125 Adarotene Adarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor...
T13665 DT2216 DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extremel...
T12516 Polyinosinic-polycytidylic acid sodium Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
T12454 PI-273 PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells
T13818 Phytohemagglutinin Phytohemagglutinin is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tum...
T13815 Penicillic acid Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.Penicillic acid is a polyketide mycotoxin produced by several spec...
T11600 IBR2 IBR2 is a potent and specific RAD51 inhibitor that inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates prote...
T13336 VTP50469 VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
T16791 Rottlerin Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,...
T16363 NVP-2 NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50...
T16750 Rigosertib Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
T16745 Rhosin hydrochloride Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
T11826 LCH-7749944 LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apopto...
T11820 LAT1-IN-1 LAT1-IN-1 (BCH)  significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. i...
T16684 Puromycin aminonucleoside Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T16522 Phenoxodiol Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and s...
T8531 M-3M3FBS m-3M3FBS is a phospholipase C (PLC) activator.
T16324 Nimbolide Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis t...
T15433 GSK2795039 GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
T16163 MV1 MV1 is an IAP antagonist. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins.
T16087 Quiflapon Quiflapon causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) ...
T16075 Minerval Minerval is a fatty acid amide hydrolase inhibitor with anti-tumor effect. It binds to the plasma membrane and alters lipid organization.
T16016 Maytansinol Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.
T13476 β-Elemene β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.
T13416 ZX-29 ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...
T8464 RA-9 RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
T2733 Sarsasapogenin Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing pl...
CCT128930 hydrochloride
T6303LCAS 2453324-32-6
CCT128930 hydrochloride is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophag...
Sophoraflavanone G
T5S1000CAS 97938-30-2
Sophoraflavanone G (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
Hirsutine
TN1065CAS 7729-23-9
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and ...
Galgravin
TN1038CAS 528-63-2
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid...
Beta-mangostin
TN1019CAS 20931-37-7
Beta-Mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-Mangostin (β-Mangostin) present in Cratoxylum arboresc...
Valinomycin
TP1072CAS 2001-95-8
Valinomycin is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Se...
BTZO-1
T7845CAS 99420-15-2
BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
Gomisin N
T8297CAS 69176-52-9
Gomisin N, isolated from Schisandra chinensis, produces beneficial sedative and hypnotic bioactivity. It has the potential for use in the treatment of allergy an...
Oxysophoridine
T2S1008CAS 54809-74-4
Oxysophoridine has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective...
Ginsenoside Rg6
TN1094CAS 147419-93-0
Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cells
3'-Hydroxypterostilbene
T2S2382CAS 475231-21-1
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for ...
Myrislignan
T4S1540CAS 171485-39-5
Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a ...
Kinsenoside;(+)-Kinsenoside
T3849CAS 151870-74-5
Kinsenoside shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury ...
Ethyl pyruvate
T8030CAS 617-35-6
Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, a...
Iberdomide
T7791CAS 1323403-33-3
Iberdomide is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
R1530
TQ0317CAS 882531-87-5
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.
Thapsigargin
TQ0302CAS 67526-95-8
Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.
Deoxypodophyllotoxin
TN1087CAS 19186-35-7
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammat...
Polyporenic acid C
TN1153CAS 465-18-9
Polyporenic acid C shows inhibitory activity against human collagenase.
LY2857785
TQ0060CAS 1619903-54-6
LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).
Leachianone A
TN1856CAS 97938-31-3
Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
Sodium taurochenodeoxycholate
TN2215CAS 6009-98-9
Sodium taurochenodeoxycholate is one of the main bioactive substances of animals' bile acid. Sodium taurochenodeoxycholate induces apoptosis and shows obvious a...
Pomolic acid
TN2097CAS 13849-91-7
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
Polygalacin D
TN2091CAS 66663-91-0
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS...
Picrocrocin
TN2069CAS 138-55-6
Picrocrocin is a natural product
Lupiwighteone
TN1891CAS 104691-86-3
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
Lonicerin
TN1877CAS 25694-72-8
Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albic...
Kahweol
TN1828CAS 6894-43-5
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
3,4-Dihydroxy-5-methoxybenzoic acid
TN1237CAS 3934-84-7
3,4-Dihydroxy-5-methoxybenzoic acid reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection again...
Ginsenoside F5
TN1684CAS 189513-26-6
Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
Ginsenoside F5
TN1684CAS 189513-26-6
Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
Eriocalyxin B
TN1620CAS 84745-95-9
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
Dihydrorotenone
TN1586CAS 6659-45-6
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
Dehydroeffusol
TN1560CAS 137319-34-7
Dehydroeffusol possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively in...
Bacopaside II
TN1421CAS 382146-66-9
Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.
Azadirachtin
TN1417CAS 11141-17-6
Azadirachtin has antifungal activity, used as an insecticide.
Juglanin
TQ0089CAS 5041-67-8
Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.
Kinetin riboside
T7337CAS 4338-47-0
Kinetin riboside can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells(IC50 of 2.5 μM)
Tetramethylcurcumin
TN2269CAS 52328-97-9
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also ...
Isoalantolactone
T2829CAS 470-17-7
Isoalantolactone, isolated from Inula spp., can inhibit the growth of several types of Y cells.
Ginsenoside F2
T3916CAS 62025-49-4
Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic ...
Tectorigenin
T3488CAS 548-77-6
Tectorigenin is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation ...
Methyl protodioscin
T3771CAS 54522-52-0
Methyl protodioscin potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl pro...
Perillyl alcohol
T3314CAS 536-59-4
Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and gerany...
Polyphyllin I
T3895CAS 50773-41-6
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
Columbianadin
T3373CAS 5058-13-9
Columbianadin, one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious phar...
Bilobalide
T2808CAS 33570-04-6
Bilobalide, a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.
4-Hydroxybenzyl alcohol
T3752CAS 623-05-2
4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expressi...
(20S)-Protopanaxadiol
T2799CAS 30636-90-9
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
10-Gingerol
T3908CAS 23513-15-7
10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, p38 MAPK (p38), c-Jun N-terminal kinase ...
6-Gingerol
T3405CAS 23513-14-6
6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bo...
2-Methoxynaphthoquinone
T3008CAS 2348-82-5
MNQ induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated t...
3,4-Dimethoxycinnamic acid
T3759CAS 2316-26-9
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts an...
2-Deoxy-D-glucose
T6742CAS 154-17-6
2-Deoxy-D-glucose is an analog of glucose, which is a glycolytic inhibitor with antiviral activity.
Betulinaldehyde
T3796CAS 13159-28-9
Betulinaldehyde has the inhibition of Saccharomyces sp and alpha-glucosidase. Betulinaldehyde induces apoptosis in mouse B16 2F2 cells. Betulinaldehyde has anti-...
4-Hydroxybenzyl alcohol
T3752CAS 623-05-2
4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expressi...
Atractylenolide III
T3902CAS 73030-71-4
Atractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential...
Urolithin A
T7174CAS 1143-70-0
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
9-dihydro-13-acetylbaccatin III
T5132CAS 142203-65-4
9-Dihydro-13-acetylbaccatin III is an apoptosis inducer. It shows cytotoxicity against the MCF7 cell line and drug-resistant cell line MCF7-ADR.
Flavokawain C
T5753CAS 37308-75-1
Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the tre...
Britannin
T5793CAS 33627-28-0
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
5-Benzylidene-3-ethyl rhodanine
T5822CAS 18331-34-5
5-Benzylidene-3-ethyl rhodanine(BTR-1) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.
HYPOCRELLIN B
T5780CAS 123940-54-5
HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer c...
3-​O-​Acetyloleanolic acid
T2S1396CAS 4339-72-4
3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1...
Epibrassinolide
T5514CAS 78821-43-9
Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, is a natural brassinosteroid (BR) derivative, is a plant regulator with a simila...
Glycochenodeoxycholic Acid
T4588CAS 640-79-9
Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxych...
SecinH3
T6664CAS 853625-60-2
SecinH3 is selective cytohesin inhibitor.
Glycochenodeoxycholic Acid
T4588CAS 640-79-9
Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxych...
β-Elemonic Acid
T2S0618CAS 28282-25-9
1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antica...
Nitidine chloride
T5S0761CAS 13063-04-2
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
Rubiadin
T4241CAS 117-02-2
Rubiadin possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner.
Concanavalin A
T4004CAS 11028-71-0
Concanavalin A is a plant lectin that is a T cell mitogen. It induces apoptosis in human fibroblasts.
Protosappanin B
T6S1780CAS 102036-29-3
1. Protosappanin B significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappa...
Methylisoindigotin
T1882CAS 97207-47-1
Meisoindigo is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
Soyasapogenol B
TN2225CAS 595-15-3
Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
NBDHEX
T12189CAS 787634-60-0
NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
CLEFMA
T9582CAS 1246964-32-8
CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
Ezatiostat hydrochloride
T22776CAS 286942-97-0
Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatme...
Dextran sulfate sodium salt (MW 16000-24000)
T13647CAS 9011-18-1
Dextran sulfate sodium salt (MW 16000-24000) is an anhydrous glucose polymer with a molecular weight range of 16000-24000. The sodium salt inhibits the replicati...
W-7 HCl
T20792CAS 61714-27-0
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
Sodium Oxamate
T19831CAS 565-73-1
Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis t...
physalin F
T8716CAS 57423-71-9
Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immun...
Naphthazarin
T8678CAS 475-38-7
Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerizatio...
TCS PrP Inhibitor 13
T23450CAS 34320-83-7
TCS PrP Inhibitor 13 is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.
Sulforaphene
TL0016CAS 592-95-0
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
Aurintricarboxylic acid
T8333CAS 4431-00-9
Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
Actein
T7190CAS 18642-44-9
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
Bafilomycin A1
T6740CAS 88899-55-2
Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuola...
Ponicidin
T2S1975CAS 52617-37-5
Ponicidin is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicid...
Voreloxin hydrochloride
T22456CAS 175519-16-1
Voreloxin hydrochloride is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.
Etalocib
T22358CAS 161172-51-6
Etalocib is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotr...
TAS6417
T16996CAS 1661854-97-2
TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
Talampanel
T16977CAS 161832-65-1
Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neu...
Tributyrin
T19676CAS 60-01-5
Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses t...
Glyphosate
T19857CAS 1071-83-6
Glyphosate is an herbicide. It also is a possible carcinogen to humans.
Supinoxin
T16961CAS 888478-45-3
Supinoxin is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and in...
TJ191
T9104CAS 1522415-97-9
TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
(-)-Epipodophyllotoxin
TN7041CAS 4375-07-9
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Ep...
PHYTOSPHINGOSINE
T9503CAS 554-62-1
Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and trans...
ZZW-115 hydrochloride
T9465CAS 10122-45-9
ZZW-115 hydrochloride inhibits the activity of NUPR1.
ARRY 520 hydrochloride
TQ0318LCAS 1385020-40-5
ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative acti...
Bax inhibitor peptide V5 acetate
T10463LCAS T10463L
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
Bigelovin
TN6735CAS 3668-14-2
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR p...
WM-3835
T9102CAS 2229025-70-9
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell prolifera...
Tebufenozide
T19823CAS 112410-23-8
Tebufenozide is a novel nonsteroidal ecdysone agonist. It shows good efficacy and playing an increasingly important role in the control of Lepidopteran pests.
Pitstop 2
T26357CAS 1419320-73-2
Pitstop 2 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential ...
Clovamide
T26288CAS 53755-02-5
Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a poten...
SKI-178
T9014CAS 1259484-97-3
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsi...
Inecalcitol
T24166CAS 163217-09-2
Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.
(6R)-FR054
T8934CAS 10378-06-0
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.
DC_AC50
T21876CAS 497061-48-0
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemothe...
SW-106065
T8762CAS 62289-81-0
SW-106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant periphe...
TAK-243
T16974CAS 1450833-55-2
TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as ...
SC-43
T8478CAS 1400989-25-4
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and ...
nor-NOHA acetate
T12240CAS 1140844-63-8
nor-NOHA acetate is a reversible inhibitor of arginase, with anti-leukemic activity, effective in endothelial dysfunction, immunosuppression, and metabolism.
Rimiducid
T14298CAS 195514-63-7
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
BO-264
T8492CAS 2408648-20-2
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).
Bisindolylmaleimide VIII acetate
T10549CAS 138516-31-1
Bisindolylmaleimide VIII acetate is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-...
Batabulin
T10460CAS 195533-53-0
Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization....
Garcinol
T11366CAS 78824-30-3
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and ant...
(E/Z)-BCI
T11139CAS 15982-84-0
(E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB p...
Cl-amidine hydrochloride
T10831LCAS 1373232-26-8
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in ca...
Alexidine dihydrochloride
T14177CAS 1715-30-6
Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent t...
UC-514321
T13950CAS 299420-83-0
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, wi...
ACBI1
T17350CAS 2375564-55-7
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s ...
Adarotene
T14125CAS 496868-77-0
Adarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor...
DT2216
T13665CAS 2365172-42-3
DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extremel...
Polyinosinic-polycytidylic acid sodium
T12516CAS 42424-50-0
Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
PI-273
T12454CAS 925069-34-7
PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells
Phytohemagglutinin
T13818CAS 9008-97-3
Phytohemagglutinin is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tum...
Penicillic acid
T13815CAS 90-65-3
Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.Penicillic acid is a polyketide mycotoxin produced by several spec...
IBR2
T11600CAS 313526-24-8
IBR2 is a potent and specific RAD51 inhibitor that inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates prote...
VTP50469
T13336CAS 2169916-18-9
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
Rottlerin
T16791CAS 82-08-6
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,...
NVP-2
T16363CAS 1263373-43-8
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50...
Rigosertib
T16750CAS 592542-59-1
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
Rhosin hydrochloride
T16745CAS 1281870-42-5
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
LCH-7749944
T11826CAS 796888-12-5
LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apopto...
LAT1-IN-1
T11820CAS 20448-79-7
LAT1-IN-1 (BCH)  significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. i...
Puromycin aminonucleoside
T16684CAS 58-60-6
Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
Phenoxodiol
T16522CAS 81267-65-4
Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and s...
m-3M3FBS
T8531CAS 200933-14-8
m-3M3FBS is a phospholipase C (PLC) activator.
Nimbolide
T16324CAS 25990-37-8
Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis t...
GSK2795039
T15433CAS 1415925-18-6
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
MV1
T16163CAS 1001600-54-9
MV1 is an IAP antagonist. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins.
Quiflapon
T16087CAS 136668-42-3
Quiflapon causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) ...
Minerval
T16075CAS 56472-29-8
Minerval is a fatty acid amide hydrolase inhibitor with anti-tumor effect. It binds to the plasma membrane and alters lipid organization.
Maytansinol
T16016CAS 57103-68-1
Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.
β-Elemene
T13476CAS 515-13-9
β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.
ZX-29
T13416CAS 2254805-62-2
ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...
RA-9
T8464CAS 919091-63-7
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
Sarsasapogenin
T2733CAS 126-19-2
Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing pl...