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Apoptosis Apoptosis

Apoptosis

Cat No. product name
T11366 Garcinol Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and an...
T11820 LAT1-IN-1 LAT1-IN-1 (BCH)  significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. ...
T11826 LCH-7749944 LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apopt...
T12516 Polyinosinic-polycytidylic acid sodium Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible ge...
T13336 VTP50469 VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
T13476 β-Elemene β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.
T13647 Dextran sulfate sodium salt (MW 16000-24000) Dextran sulfate sodium salt (MW 16000-24000) is an anhydrous glucose polymer with a molecular weight range of 16000-24000. The sodium salt inhibits the replicat...
T13815 Penicillic acid Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.Penicillic acid is a polyketide mycotoxin produced by several spe...
T13818 Phytohemagglutinin Phytohemagglutinin is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tu...
T14177 Alexidine dihydrochloride Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent ...
T14298 Rimiducid Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affi...
T15433 GSK2795039 GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase ...
T16363 NVP-2 NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC5...
T16684 Puromycin aminonucleoside Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T16745 Rhosin hydrochloride Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ ...
T16750 Rigosertib Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, whic...
T16791 Rottlerin Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η...
T16974 TAK-243 TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as...
T16996 TAS6417 TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
T1882 Methylisoindigotin Meisoindigo is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
T19831 Sodium Oxamate Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis ...
T20792 W-7 HCl W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and ha...
T21876 DC_AC50 DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemoth...
T2733 Sarsasapogenin Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing p...
T2799 (20S)-Protopanaxadiol (20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
T2808 Bilobalide Bilobalide, a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.
T2829 Isoalantolactone Isoalantolactone, isolated from Inula spp., can inhibit the growth of several types of Y cells.
T2S0618 β-Elemonic Acid 1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antic...
T2S1008 Oxysophoridine Oxysophoridine has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotectiv...
T2S1396 3-​O-​Acetyloleanolic acid 3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G...
T2S2382 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for...
T3008 2-Methoxynaphthoquinone MNQ induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated ...
T3314 Perillyl alcohol Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geran...
T3373 Columbianadin Columbianadin, one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious pha...
T3405 6-Gingerol 6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the b...
T3488 Tectorigenin Tectorigenin is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation...
T3752 4-Hydroxybenzyl alcohol 4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI express...
T3752 4-Hydroxybenzyl alcohol 4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI express...
T3759 3,4-Dimethoxycinnamic acid 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts a...
T3771 Methyl protodioscin Methyl protodioscin potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl pr...
T3796 Betulinaldehyde Betulinaldehyde has the inhibition of Saccharomyces sp and alpha-glucosidase. Betulinaldehyde induces apoptosis in mouse B16 2F2 cells. Betulinaldehyde has anti...
T3849 Kinsenoside;(+)-Kinsenoside Kinsenoside shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury...
T3895 Polyphyllin I Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, ...
T3902 Atractylenolide III Atractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potentia...
T3908 10-Gingerol 10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, p38 MAPK (p38), c-Jun N-terminal kinase...
T3916 Ginsenoside F2 Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic...
T4004 Concanavalin A Concanavalin A is a plant lectin that is a T cell mitogen. It induces apoptosis in human fibroblasts.
T4241 Rubiadin Rubiadin possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner.
T4588 Glycochenodeoxycholic Acid Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxyc...
T4588 Glycochenodeoxycholic Acid Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxyc...
T4S1540 Myrislignan Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a...
T5132 9-dihydro-13-acetylbaccatin III 9-Dihydro-13-acetylbaccatin III is an apoptosis inducer. It shows cytotoxicity against the MCF7 cell line and drug-resistant cell line MCF7-ADR.
T5514 Epibrassinolide Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, is a natural brassinosteroid (BR) derivative, is a plant regulator with a simil...
T5753 Flavokawain C Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the tr...
T5780 HYPOCRELLIN B HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer ...
T5793 Britannin Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
T5822 5-Benzylidene-3-ethyl rhodanine 5-Benzylidene-3-ethyl rhodanine(BTR-1) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.
T5S0761 Nitidine chloride 1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-772...
T5S1000 Sophoraflavanone G Sophoraflavanone G (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
T6664 SecinH3 SecinH3 is selective cytohesin inhibitor.
T6740 Bafilomycin A1 Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuol...
T6742 2-Deoxy-D-glucose 2-Deoxy-D-glucose is an analog of glucose, which is a glycolytic inhibitor with antiviral activity.
T6S1780 Protosappanin B 1. Protosappanin B significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosapp...
T7174 Urolithin A Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T7337 Kinetin riboside Kinetin riboside can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells(IC50 of 2.5 μM)
T7791 Iberdomide Iberdomide is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
T7845 BTZO-1 BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
T8030 Ethyl pyruvate Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, ...
T8297 Gomisin N Gomisin N, isolated from Schisandra chinensis, produces beneficial sedative and hypnotic bioactivity. It has the potential for use in the treatment of allergy a...
T8464 RA-9 RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9...
T8478 SC-43 SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and...
T8492 BO-264 BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).
T8531 m-3M3FBS m-3M3FBS is a phospholipase C (PLC) activator.
T8678 Naphthazarin Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerizati...
T8716 physalin F Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immu...
T8717 Examorelin Aceate (140703-51-1(free base)) Hexarelin is a growth hormone capable of apoptosis inhibition
T8762 SW-106065 SW-106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant periph...
T8934 FR054 FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.
T9014 SKI-178 SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrins...
TL0016 Sulforaphene Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes can...
TN1038 Galgravin Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloi...
TN1065 Hirsutine Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and...
TN1087 Deoxypodophyllotoxin Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
TN1421 Bacopaside II Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.
TN1586 Dihydrorotenone Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
TN1684 Ginsenoside F5 Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
TN1684 Ginsenoside F5 Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
TN1877 Lonicerin Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albi...
TN2069 Picrocrocin Picrocrocin is a natural product
TN2091 Polygalacin D Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
TN2215 Sodium taurochenodeoxycholate Sodium taurochenodeoxycholate is one of the main bioactive substances of animals' bile acid. Sodium taurochenodeoxycholate induces apoptosis and shows obvious ...
TN2225 Soyasapogenol B Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
TN2269 Tetramethylcurcumin Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also...
TQ0302 Thapsigargin Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.
Garcinol
T11366CAS 78824-30-3
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and an...
LAT1-IN-1
T11820CAS 20448-79-7
LAT1-IN-1 (BCH)  significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. ...
LCH-7749944
T11826CAS 796888-12-5
LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apopt...
Polyinosinic-polycytidylic acid sodium
T12516CAS 42424-50-0
Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible ge...
VTP50469
T13336CAS 2169916-18-9
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
β-Elemene
T13476CAS 515-13-9
β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.
Dextran sulfate sodium salt (MW 16000-24000)
T13647CAS 9011-18-1
Dextran sulfate sodium salt (MW 16000-24000) is an anhydrous glucose polymer with a molecular weight range of 16000-24000. The sodium salt inhibits the replicat...
Penicillic acid
T13815CAS 90-65-3
Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.Penicillic acid is a polyketide mycotoxin produced by several spe...
Phytohemagglutinin
T13818CAS 9008-97-3
Phytohemagglutinin is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tu...
Alexidine dihydrochloride
T14177CAS 1715-30-6
Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent ...
Rimiducid
T14298CAS 195514-63-7
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affi...
GSK2795039
T15433CAS 1415925-18-6
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase ...
NVP-2
T16363CAS 1263373-43-8
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC5...
Puromycin aminonucleoside
T16684CAS 58-60-6
Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
Rhosin hydrochloride
T16745CAS 1281870-42-5
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ ...
Rigosertib
T16750CAS 592542-59-1
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, whic...
Rottlerin
T16791CAS 82-08-6
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η...
TAK-243
T16974CAS 1450833-55-2
TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as...
TAS6417
T16996CAS 1661854-97-2
TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
Methylisoindigotin
T1882CAS 97207-47-1
Meisoindigo is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
Sodium Oxamate
T19831CAS 565-73-1
Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis ...
W-7 HCl
T20792CAS 61714-27-0
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and ha...
DC_AC50
T21876CAS 497061-48-0
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemoth...
Sarsasapogenin
T2733CAS 126-19-2
Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing p...
(20S)-Protopanaxadiol
T2799CAS 30636-90-9
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
Bilobalide
T2808CAS 33570-04-6
Bilobalide, a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.
Isoalantolactone
T2829CAS 470-17-7
Isoalantolactone, isolated from Inula spp., can inhibit the growth of several types of Y cells.
β-Elemonic Acid
T2S0618CAS 28282-25-9
1. Beta-Elemonic acid exhibits anti-inflammatory effects. 2. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the antic...
Oxysophoridine
T2S1008CAS 54809-74-4
Oxysophoridine has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotectiv...
3-​O-​Acetyloleanolic acid
T2S1396CAS 4339-72-4
3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G...
3'-Hydroxypterostilbene
T2S2382CAS 475231-21-1
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 µM for...
2-Methoxynaphthoquinone
T3008CAS 2348-82-5
MNQ induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated ...
Perillyl alcohol
T3314CAS 536-59-4
Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geran...
Columbianadin
T3373CAS 5058-13-9
Columbianadin, one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious pha...
6-Gingerol
T3405CAS 23513-14-6
6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the b...
Tectorigenin
T3488CAS 548-77-6
Tectorigenin is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation...
4-Hydroxybenzyl alcohol
T3752CAS 623-05-2
4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI express...
4-Hydroxybenzyl alcohol
T3752CAS 623-05-2
4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI express...
3,4-Dimethoxycinnamic acid
T3759CAS 2316-26-9
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts a...
Methyl protodioscin
T3771CAS 54522-52-0
Methyl protodioscin potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl pr...
Betulinaldehyde
T3796CAS 13159-28-9
Betulinaldehyde has the inhibition of Saccharomyces sp and alpha-glucosidase. Betulinaldehyde induces apoptosis in mouse B16 2F2 cells. Betulinaldehyde has anti...
Kinsenoside;(+)-Kinsenoside
T3849CAS 151870-74-5
Kinsenoside shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury...
Polyphyllin I
T3895CAS 50773-41-6
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, ...
Atractylenolide III
T3902CAS 73030-71-4
Atractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potentia...
10-Gingerol
T3908CAS 23513-15-7
10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, p38 MAPK (p38), c-Jun N-terminal kinase...
Ginsenoside F2
T3916CAS 62025-49-4
Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic...
Concanavalin A
T4004CAS 11028-71-0
Concanavalin A is a plant lectin that is a T cell mitogen. It induces apoptosis in human fibroblasts.
Rubiadin
T4241CAS 117-02-2
Rubiadin possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner.
Glycochenodeoxycholic Acid
T4588CAS 640-79-9
Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxyc...
Glycochenodeoxycholic Acid
T4588CAS 640-79-9
Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxyc...
Myrislignan
T4S1540CAS 171485-39-5
Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a...
9-dihydro-13-acetylbaccatin III
T5132CAS 142203-65-4
9-Dihydro-13-acetylbaccatin III is an apoptosis inducer. It shows cytotoxicity against the MCF7 cell line and drug-resistant cell line MCF7-ADR.
Epibrassinolide
T5514CAS 78821-43-9
Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, is a natural brassinosteroid (BR) derivative, is a plant regulator with a simil...
Flavokawain C
T5753CAS 37308-75-1
Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the tr...
HYPOCRELLIN B
T5780CAS 123940-54-5
HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer ...
Britannin
T5793CAS 33627-28-0
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
5-Benzylidene-3-ethyl rhodanine
T5822CAS 18331-34-5
5-Benzylidene-3-ethyl rhodanine(BTR-1) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.
Nitidine chloride
T5S0761CAS 13063-04-2
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-772...
Sophoraflavanone G
T5S1000CAS 97938-30-2
Sophoraflavanone G (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
SecinH3
T6664CAS 853625-60-2
SecinH3 is selective cytohesin inhibitor.
Bafilomycin A1
T6740CAS 88899-55-2
Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuol...
2-Deoxy-D-glucose
T6742CAS 154-17-6
2-Deoxy-D-glucose is an analog of glucose, which is a glycolytic inhibitor with antiviral activity.
Protosappanin B
T6S1780CAS 102036-29-3
1. Protosappanin B significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosapp...
Urolithin A
T7174CAS 1143-70-0
Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
Kinetin riboside
T7337CAS 4338-47-0
Kinetin riboside can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells(IC50 of 2.5 μM)
Iberdomide
T7791CAS 1323403-33-3
Iberdomide is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
BTZO-1
T7845CAS 99420-15-2
BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
Ethyl pyruvate
T8030CAS 617-35-6
Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, ...
Gomisin N
T8297CAS 69176-52-9
Gomisin N, isolated from Schisandra chinensis, produces beneficial sedative and hypnotic bioactivity. It has the potential for use in the treatment of allergy a...
RA-9
T8464CAS 919091-63-7
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9...
SC-43
T8478CAS 1400989-25-4
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and...
BO-264
T8492CAS 2408648-20-2
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).
m-3M3FBS
T8531CAS 200933-14-8
m-3M3FBS is a phospholipase C (PLC) activator.
Naphthazarin
T8678CAS 475-38-7
Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerizati...
physalin F
T8716CAS 57423-71-9
Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immu...
Examorelin Aceate (140703-51-1(free base))
T8717CAS T8717
Hexarelin is a growth hormone capable of apoptosis inhibition
SW-106065
T8762CAS 62289-81-0
SW-106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant periph...
FR054
T8934CAS 10378-06-0
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.
SKI-178
T9014CAS 1259484-97-3
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrins...
Sulforaphene
TL0016CAS 592-95-0
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes can...
Galgravin
TN1038CAS 528-63-2
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloi...
Hirsutine
TN1065CAS 7729-23-9
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and...
Deoxypodophyllotoxin
TN1087CAS 19186-35-7
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
Bacopaside II
TN1421CAS 382146-66-9
Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.
Dihydrorotenone
TN1586CAS 6659-45-6
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
Ginsenoside F5
TN1684CAS 189513-26-6
Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
Ginsenoside F5
TN1684CAS 189513-26-6
Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
Lonicerin
TN1877CAS 25694-72-8
Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albi...
Picrocrocin
TN2069CAS 138-55-6
Picrocrocin is a natural product
Polygalacin D
TN2091CAS 66663-91-0
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
Sodium taurochenodeoxycholate
TN2215CAS 6009-98-9
Sodium taurochenodeoxycholate is one of the main bioactive substances of animals' bile acid. Sodium taurochenodeoxycholate induces apoptosis and shows obvious ...
Soyasapogenol B
TN2225CAS 595-15-3
Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
Tetramethylcurcumin
TN2269CAS 52328-97-9
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also...
Thapsigargin
TQ0302CAS 67526-95-8
Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.