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FOXO3

FOXO3 belongs to the O subclass of the forkhead transcription factor family (Forkhead box O), a human protein encoded by the gene, which has the ability to be inhibited and translocated out of the nucleus when phosphorylated by proteins such as Akt/PKB in the PI3K signaling pathway, and has a regulatory function in apoptosis, the cardiovascular system, infertility, lymphocyte proliferation, inflammation, metabolism, and oxidative stress, among others, which is considered as a tumor suppressor.

Broussochalcone A
T7259499217-68-2
Broussochalcone A is a natural antioxidant and xanthine oxidase inhibitor (IC50 = 2.21 μM) that scavenges free radicals, inhibits iron-induced lipid peroxidation, and reduces nitric oxide synthesis in LPS-activated macrophages. Broussochalcone A induces apoptosis in human renal carcinoma cells by increasing ROS levels and activating the FOXO3 signaling pathway. Broussochalcone A is also a novel NR4A1 inhibitor that induces apoptosis in pancreatic cancer cells through NR4A1-dependent pathways.
  • $198
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BN201
T146931361200-34-1
BN201 (OCS-05) is a drug with neuroprotective and myelin repair effects, which acts mainly by activating serum glucocorticoid kinase-2 (SGK2), which in turn activates the FOXO3 pathway to promote neuronal survival and myelin repair. It is mainly used for the treatment of inflammatory neurological diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).BN201 is able to regulate multiple kinases in the insulin growth factor 1 (IGF1) pathway and cross the blood-brain barrier.
  • $293
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Pinostrobin
TN2082480-37-5
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of ce
  • $56
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LOM612
T194052173232-79-4In house
LOM612 is a potent and specific FOXO relocator that induces nuclear translocation of the FOXO3a reporter protein as well as endogenous FOXO3a and FOXO1 in a dose-dependent manner in U2OS cells, down-regulates the expression of c-Myc and cyclin D1, and has anti-proliferative effects in human cancer cell lines.
  • $1,110
6-8 weeks
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TargetMol | Citations Cited