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FOXO3 belongs to the O subclass of the forkhead transcription factor family (Forkhead box O), a human protein encoded by the gene, which has the ability to be inhibited and translocated out of the nucleus when phosphorylated by proteins such as Akt/PKB in the PI3K signaling pathway, and has a regulatory function in apoptosis, the cardiovascular system, infertility, lymphocyte proliferation, inflammation, metabolism, and oxidative stress, among others, which is considered as a tumor suppressor.
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