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Results for "

α2c

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    37
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • Natural Products
    1
    TargetMol | Natural_Products
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    3
    TargetMol | Isotope_Products
α2c adrenoceptor agonist 1
T87683928115-79-1
Compound A (α2C adrenoceptor agonist 1) is an orally active, highly selective α2C-adrenoceptor agonist that does not penetrate the central nervous system. It exhibits EC50 and Ki values of 108 nM and 12 nM, respectively. This compound is utilized in research on nasal congestion [1].
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10-14 weeks
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Fiduxosin
ABT 980, A 185980.1
T11286208993-54-8In house
Fiduxosin is a selective and potent α1-adrenoceptor antagonist with inhibitory effects on α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, with Ki values of 0.160 nM, 24.9 nM and 0.920 nM, respectively. Fiduxosin can be used for the treatment of benign prostatic hyperplasia.
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8-10 weeks
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Lusaperidone
R107474
T11894214548-46-6In house
Lusaperidone (R107474) is a potent α2-adrenergic receptor antagonist, a potential radioligand for the α (2)-adrenergic receptor, with inhibitory effects on α2A and α2C, with Ki values of 0.13 and 0.15 nM, respectively.
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6-8 weeks
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Benzquinamide
P2647, BZQ, Benzoquinamide
T1234363-12-7In house
Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzquinamide for α2A, α2B, and α2C adrenergic receptor (α2-AR) were 1,365, 691, and 545 nM, respectively. 545 nM, respectively.
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3-6 months
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OPC-28326
T13804167626-17-7In house
OPC-28326 is a specific an α2-adrenergic receptor antagonist and acts as a peripheral vasodilator. OPC-28326 inhibits α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively.
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8-10weeks
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TargetMol | Inhibitor Sale
jp1302
T2288280259-18-3In house
JP1302 is a selective α2C adrenoceptor antagonist with a Kb value of 16 nM and a Ki of 28 nM for human α2C receptors.JP1302 has antidepressant activity, disrupts the FACT complex and degrades histone H1.JP1302 has been used in the study of neuropsychiatric disorders, acute renal failure, and renal injury.
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6-8 weeks
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Fipamezole
JP-1730, JP1730, JP 1730, BVF-025
T24064150586-58-6In house
Fipamezole is a potent alpha2 adrenergic receptor antagonist that may be useful for studying autonomic dysfunction in Parkinson's disease.
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6-8weeks
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TargetMol | Inhibitor Sale
orm-10921
ORM10921, ORM 10921
T28267610782-82-6In house
ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies.
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6-8weeks
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TargetMol | Inhibitor Sale
NP10679
T734472914889-88-4In house
NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.NP10679 inhibits histamine H1, hERG channels, and CYP enzymes, and may be useful in the study of epilepsy and ischemic stroke.
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6-8 weeks
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Xylometazoline hydrochloride
Xylometazoline HCl
T00421218-35-5
Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant.
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TargetMol | Inhibitor Sale
Risperidone
Risperidal, R 64 766
T0351106266-06-2
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
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Brexpiprazole
OPC-34712
T2306913611-97-9
Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.
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Piribedil
EU-4200, Trivastan, ET-495, Trivastal
T32783605-01-4
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
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Guanabenz Acetate
Wy8678 acetate, BR-750, Wytensin
T652223256-50-0
Guanabenz Acetate (Wytensin) is a specific agonist of adrenergic receptor. The pEC50 for α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor is 8.25, 7.01 and ~5, respectively.
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Benzylamine hydrochloride
TN34973287-99-8
Benzylamine hydrochloride, made of benzylamine and hydrochloric acid, is used to treat motion sickness and ascariasis, with antiemesis properties.
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TargetMol | Inhibitor Sale
AGN 192836
T10264171102-29-7In house
AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7 nM, 41 nM, and 6.6 nM for the α2A, α2B, and α2C receptors, respectively.
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8-10 weeks
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Lurasidone hydrochloride
Lurasidone HCl, SM-13496 Hydrochloride
T1735367514-88-3
Lurasidone hydrochloride (Lurasidone HCl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antagonist, an antagonist of the adrenergic α2A and α2C receptors, as well as a partial serotonin 5-HT1A receptor agonist. It is used in the treatment of schizophrenia and bipolar disorder.
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JP1302 dihydrochloride
T117261259314-65-2
JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.
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TargetMol | Inhibitor Sale
Lurasidone D8 Hydrochloride
SM-13496 D8
T11892
Lurasidone D8 Hydrochloride is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C, and is the deuterium labeled Lurasidone.
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(S)-Terazosin
T12815109351-33-9
(S)-Terazosin is an active S-enantiomer of Terazosin and acts as a potent, high-affinity antagonist of α-adrenoceptors [α1a, α1b, and α1d-adrenoceptors] with Ki values of 3.91 nM, 0.79 nM, and 1.16 nM, respectively.
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6-8 weeks
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TDIQ hydrochloride
T20423415052-05-8
TDIQ hydrochloride is an analog of Amphetamine with high affinity for the α2-adrenergic receptor. This compound acts as a selective ligand for α2-adrenergic receptors, displaying Ki values of 75 nM, 95 nM, and 65 nM for α2A-, α2B-, and α2C-adrenergic receptors, respectively.
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10-14 weeks
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Allyphenyline oxalate
T2043761092984-08-1
The pKi values of Allyphenyline oxalate (compound 9) for the α2-adrenergic receptor subtypes α2A, α2B, and α2C are 7.24, 6.47, and 7.07, respectively.
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10-14 weeks
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Asenapine
Org 5222, ME2136, HSDB 8061
T2136065576-45-6
Asenapine (Org 5222) is a 5-HT receptor, adrenergic receptor, dopamine receptor, and histamine receptor antagonist with antipsychotic effects that is used to treat schizophrenia and manic or mixed episodes associated with bipolar 1 disorder.721483-46-5
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7-10 days
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B-HT 933 dihydrochloride
T2178736067-72-8
Azepexole dihydrochloride (B-HT 933), a potent and selective alpha 2-adrenoceptor agonist, exhibits affinity for α2A-, α2B-, and α2C-adrenoceptor subtypes with pKis of 8.3, 7.6, and 7.5, respectively [1]. It elicits a concentration-dependent inhibition of peristaltic contractions, evidenced by an IC50 of 78.72 nM.
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6-8 weeks
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