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Food as Medicine Compound

The concept of ‘medicinal foods’ posits that certain foods possess both nutritional and therapeutic value. Modern medical research indicates that a balanced diet plays a pivotal role in regulating inflammatory responses, stabilising blood glucose levels, modulating blood pressure and lipid profiles, promoting digestion, and facilitating the clearance of metabolic waste. The isolated compounds derived from such medicinal foods can be employed to elucidate the precise roles these bioactive constituents plays within an given biological systems.

Paclitaxel
Taxol, NSC 125973
T096833069-62-4
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
  • $34
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5-O-Caffeoylshikimic acid
TN129573263-62-4
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.
  • $98
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Docosahexaenoic Acid
DHA, Cervonic acid
T53696217-54-5
Docosahexaenoic Acid (DHA) is an essential omega-3 fatty acid prevalent in the brain and retina.
  • $34
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Prostaglandin E2
Prostaglandin E2 (PGE2), PGE2, Dinoprostone
T5014363-24-6
Prostaglandin E2 (PGE2) is a natural hormone-like substance involved in various physiological functions, including the contraction and relaxation of smooth muscles, dilation and constriction of blood vessels, regulation of blood pressure, and modulation of inflammation. It can be used to induce neuropathic pain models.
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Punicalagin
T392165995-63-3
Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and ch
  • $38
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(-)-Catechin
(-)-Cianidanol, (-)-Catechuic acid
T1359718829-70-4
(-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
  • $40
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Brefeldin A
Decumbin, Cyanein, BFA, Ascotoxin
T606220350-15-6
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activity.
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Ginkgetin
T4S2126481-46-9
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead
  • $40
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Quercetin
Sophoretin
T2174117-39-5
Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
  • $42
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Xanthohumol
T33426754-58-1
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
  • $61
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Arachidonic acid
Vevodar, Immunocytophyte, Immunocytophyt, arachidonate
T4129506-32-1
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 essential fatty acid that serves as a major component of biological membranes and animal phospholipids. It is synthesized from dietary linoleic acid and acts as a precursor to lipid mediators such as prostaglandins, thromboxanes, and leukotrienes. Arachidonic acid can improve cognitive responses and cardiovascular function and is commonly used to induce paw edema models.
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Robinin
NSC 9222
T2S0265301-19-9
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry.
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Procyanidin B1
TQ020520315-25-7
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
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Resveratrol
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
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Erianin
T386495041-90-0
Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metabolism in a JNK/SAPK-dependent manner a
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Ganoderic acid A
T6S114181907-62-2
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis and suppression of invasion in human
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Mulberrin
Kuwanon C
TQ016162949-79-5
Mulberrin (Kuwanon C) is an inhibitor of OATP2B1-mediated estrone-3-sulfate (E3S) uptake (IC50: 1.8 ±1.5 μM).
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Capsaicin
Zostrix, Qutenza, 8-Methyl-N-vanillyl-trans-6-nonenamide, (E)-Capsaicin
T1062404-86-4
Capsaicin is an active natural component found in chili peppers and acts as a TRPV1 agonist (EC50 = 0.29 μM). It possesses multiple activities, including pain relief, antitumor, anti-inflammatory, antioxidant, and neuroprotective effects, as well as some neurotoxicity. Capsaicin can be used to establish itch models.
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Digitonin
T272111024-24-1
Digitonin is a natural product of the glycoside family and is a detergent. Digitonin has antitumor activity, binds to cholesterol molecules to increase the permeability of cell membranes, and is active in the cleavage of cell membranes in a wide range of cells.
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Monocrotaline
Crotaline
T2803315-22-0
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid extracted from the seeds of Crotalaria plants. It inhibits organic cation transporters OCT-1 and OCT-2, with IC50 values of 36.8 µM and 1.8 mM, respectively. Monocrotaline exhibits antitumor activity and shows certain cytotoxicity against liver cancer cells such as HepG2. It is also commonly used to induce pulmonary arterial hypertension models in rodents.
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Luteolin
Luteolol, Luteoline, Flacitran, Digitoflavone
T1027491-70-3
Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antimicrobial, antiviral, antiallergic, and procoagulant.
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Serotonin
5-hydroxytryptamine, 5-HT
TN243750-67-9
Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin regulates the nervous system, digestive system and cardiovascular system.
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1,2,3,6-Tetragalloylglucose
TeGG, 1,2,3,6-Tetra-O-galloyl-β-D-glucose
TN116079886-50-3
1,2,3,6-Tetragalloylglucose (TeGG) has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransferase 1 A1 (UGT1A1, Ki = 1.68 μM).
  • $169
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L-Ascorbic acid
Vitamin C, L-Ascorbate, L(+)-Ascorbic acid, Ascorbic acid
T092850-81-7
L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.
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