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Results for "

7acc-1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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7ACC1
DEAC, D 1421, Coumarin D 1421, 7-(Diethylamino)coumarin-3-carboxylic acid
T584550995-74-9
7ACC1 (D 142) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.
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1-Methyl-7-nitroisatoic anhydride
1M7
T1399573043-80-8
1-Methyl-7-nitroisatoic anhydride (1M7) is a reagent. It detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity.
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7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one
T203325314742-00-2
7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one (Compound 1) serves as a fluorescent probe for detecting hydrogen sulfide (H2S). It is characterized by a low detection limit (4×10^-6 mol L), high selectivity, and great sensitivity. At a concentration of 150 µg mL, it exhibits negligible cytotoxicity. The excitation wavelength is 331 nm, while in DMSO solvent, it emits at approximately 385 nm; upon addition of HS-, the fluorescence intensity significantly increases around 392 nm.
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PRMT5-targeted fluorescent ligand-1
T204511
PRMT5-targeted fluorescent ligand-1 (Compound 7) is a fluorescent ligand specific to PRMT5 that inhibits this target with an IC50 value of 29.39 nM. It demonstrates cellular imaging activity with strong fluorescence signals in MCF-7 cells, showing an IC50 of 29 nM. Additionally, it induces apoptosis (cell death). The compound's maximum excitation wavelength is 438 nm, and its maximum emission wavelength is 550 nm.
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8-(4-ethynylphenyl)-1,3,5,7-tetramethyl BODIPY
T205841628729-80-6
8-(4-ethynylphenyl)-1,3,5,7-tetramethyl BODIPY is an organic fluorescent dye characterized by an ethynylphenyl group at the 8-position of the boron dipyrromethene (BODIPY) structure and methyl substituents at the 1, 3, 5, and 7 positions. It boasts a high fluorescence quantum yield and specific chemical properties, making it useful for applications such as fluorescence imaging.
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7-10 days
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8-(4-Bromophenyl)-1,3,5,7-tetramethyl BODIPY
T205843850534-66-6
8-(4-bromophenyl)-1,3,5,7-tetramethyl-BODIPY is a derivative based on the BODIPY structure, featuring four methyl groups at positions 1, 3, 5, and 7, with a para-bromophenyl group attached at position 8. This compound finds extensive use in fields such as bioimaging, chemical analysis, and materials science, serving as a fluorescent probe for imaging biological samples, detecting specific chemicals, or in the development of optical materials.
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7-10 days
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1M6
1-Methyl-6-nitroisatoic anhydride, 1M-6, 1M 6
T293034693-01-0
1M6 (1-Methyl-6-nitroisatoic anhydride) is a SHAPE reagent for the detection of RNA chemical structures.
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7-10 days
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STY-BODIPY
Styrene-BODIPY, STY-BODIPY
T365042383063-37-2
STY-BODIPY is a styrene-conjugated fluorogenic probe for radical-trapping antioxidant (RTA) activity.1 Co-autoxidation of the STY-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring the loss of absorbance at 571 nm. STY-BODIPY has been used to measure the activity of RTAs, as well as the kinetics and stoichiometry of RTA reactions in cell-free assays.1,2,3References1. Haidasz, E.A., Van Kessel, A.T.M., and Pratt, D.A. A continuous visible light spectrophotometric approach to accurately determine the reactivity of radical-trapping antioxidants. J. Org. Chem. 81(3), 737-744 (2016).2. Shah, R., Shchepinov, M.S., and Pratt, D.A. Resolving the role of lipoxygenases in the initiation and execution of ferroptosis. ACS Cent. Sci. 4(3), 387-396 (2018).3. Chauvin, J.-P.R., Haidasz, E.A., Griesser, M., et al. Polysulfide-1-oxides react with peroxyl radicals as quickly as hindered phenolic antioxidants and do so by a surprising concerted homolytic substitution. Chem. Sci. 7(10), 6347-6356 (2016). STY-BODIPY is a styrene-conjugated fluorogenic probe for radical-trapping antioxidant (RTA) activity.1 Co-autoxidation of the STY-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring the loss of absorbance at 571 nm. STY-BODIPY has been used to measure the activity of RTAs, as well as the kinetics and stoichiometry of RTA reactions in cell-free assays.1,2,3 References1. Haidasz, E.A., Van Kessel, A.T.M., and Pratt, D.A. A continuous visible light spectrophotometric approach to accurately determine the reactivity of radical-trapping antioxidants. J. Org. Chem. 81(3), 737-744 (2016).2. Shah, R., Shchepinov, M.S., and Pratt, D.A. Resolving the role of lipoxygenases in the initiation and execution of ferroptosis. ACS Cent. Sci. 4(3), 387-396 (2018).3. Chauvin, J.-P.R., Haidasz, E.A., Griesser, M., et al. Polysulfide-1-oxides react with peroxyl radicals as quickly as hindered phenolic antioxidants and do so by a surprising concerted homolytic substitution. Chem. Sci. 7(10), 6347-6356 (2016).
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7-Azido-4-methylcoumarin
7-azido-4-methyl-2H-chromen-2-one;
T3700095633-27-5
7-Azido-4-methylcoumarin (7-azido-4-methyl-2H-chromen-2-one) is a fluorescent photoactive probe used in the study of human phenol sulfotransferase (SULT1A1 or P-PST-1) substrate binding sites through photoaffinity labeling.
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7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt)
T3700284806-27-9
7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F) is a thiol-reactive fluorogenic probe.1It has been used to quantify the levels of homocysteine, cysteine, and cysteamine in human plasma.2SBD-F displays excitation emission maxima of 380 515 nm, respectively.1 1.Imai, K., Toyo'oka, T., and Watanabe, Y.A novel fluorogenic reagent for thiols: Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonateAnal. Biochem.128(2)471-473(1983) 2.Ichinose, S., Nakamura, M., Maeda, M., et al.A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasmaBiomed. Chromatogr.23(9)935-939(2009)
    7-10 days
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    Z-(L-Arg)-AMC (hydrochloride)
    T3705370375-22-3
    Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation emission maxima of 340-360 440-460 nm, respectively. 1.Zimmerman, M., Ashe, B., Yurewicz, E.C., et al.Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substratesAnal. Biochem.78(1)47-51(1977) 2.Brindley, P.J., Kalinna, B.H., Dalton, J.P., et al.Proteolytic degradation of host hemoglobin by schistosomesMol. Biochem. Parasitol.89(1)1-9(1997)
      7-10 days
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      Ac-ANW-AMC
      Ac-ANW-AMC, Ac-Ala-Asn-Trp-AMC
      T37420
      Ac-ANW-AMC is a fluorogenic substrate for the β5i LMP7 subunit of the 20S immunoproteasome. [1] Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released, and its fluorescence quantifies the activity of the β5i LMP7 subunit. AMC displays excitation emission maxima of 340-360 440-460 nm, respectively.
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      5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate
      T38123127770-45-0
      5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting compound, 5(6)-carboxy-2',7',-dichlorofluorescein, is oxidized by reactive oxygen species (ROS) and nitric oxide (NO) and displays excitation emission maxima of 504 and 530 nm, respectively, which can be quantified as a measure of oxidant production. 1.Hempel, S.L., Buettner, G.R., O'Malley, Y.Q., et al.Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123Free Radic. Biol. Med.27(1-2)146-159(1999)
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      7-Dimethylaminocoumarin-4-acetic acid
      T6495080883-54-1
      7-Dimethylaminocoumarin-4-acetic acid, catalog number T64950, CAS number 80883-54-1, is a valuable organic compound for life sciences research.
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        7-(Diethylamino)-4-methyl-2H-chromen-2-one
        T6626291-44-1
        7-(Diethylamino)-4-methyl-2H-chromen-2-one is a useful organic compound for research related to life sciences. The catalog number is T66262 and the CAS number is 91-44-1.
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          4,6-Dimethyl-7-ethylaminocoumarin
          T6763126078-25-1
          4,6-Dimethyl-7-ethylaminocoumarin is a valuable organic compound for life sciences research (Catalog number: T67631, CAS number: 26078-25-1).
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            7-Hydroxy-4-methyl-2(1H)-quinolone
            T7533220513-71-7
            7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b), a fluorescent hydroxylated derivative, serves as a probe for detecting hydroxyl radicals associated with DNA damage [1]. It should be protected from light for preservation.
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            4-6 weeks
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            Mca-(ala7,lys(dnp)9)-bradykinin
            T78435323577-36-2
            Mca-(Ala7,Lys(Dnp)9)-bradykinin is a fluorogenic substrate that demonstrates high sensitivity for ECE-1 (endothelin-converting enzyme-1). It features a (7-methoxycoumarin-4-yl)acetyl (Mca) group for fluorescence and a 2,4-dinitrophenyl (Dnp) group for quenching, yielding a significant increase in fluorescence when the substrate is cleaved [1].
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            Sulfo-Cy3-Methyltetrazine
            T810661801924-47-9
            Sulfo-Cy3-Methyltetrazine (figure 7 compound 5), a click chemistry reagent, comprises methyltetrazine linked to a water-soluble dye. This compound demonstrates good stability at physiological pH and can efficiently couple to trans-cyclooctene, showing high reactivity towards cyclooctene [1].
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            Mca-SEVNLDAEFK(Dnp)-NH2
            T818361802078-32-5
            Mca-SEVNLDAEFK(Dnp)-NH2 is a fluorogenic substrate featuring a 7-methoxycoumarin moiety whose fluorescence is quenched by the adjacent 2,4-dinitrophenyl group through resonance energy transfer. This compound serves as a probe for assessing peptidase activity; enzymatic cleavage of the amide bond separating the fluorophore and quencher results in increased fluorescence. It is particularly useful for quantifying the activity of BACE-1 [1].
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            DACM
            N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide
            T8261855145-14-7
            DACM (N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide) is a thiol-reactive fluorescent dye with an excitation wavelength (Ex) of 396 nm and an emission wavelength (Em) of 468 nm [1].
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            BTC tetrapotassium
            T82811216453-54-2
            Tetrapotassium BTC is a calcium indicator with low affinity (Kd approximately 7-26 µM) that offers favorable characteristics for cellular calcium imaging, such as extended excitation wavelengths (400 485 nm), minimal sensitivity to Mg2+, and precise ratiometric measurement [1].
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            7-Aminocoumarin
            T8324919063-57-1
            7-Aminocoumarin is a compound that exhibits high fluorescence, serving as an optical brightener and fluorescent probe [1].
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            Mca-RPPGFSAFK(Dnp)-OH TFA
            (7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl)-OH
            T83687
            Mca-RPPGFSAFK(Dnp)-OH, a fluorogenic substrate specifically designed for endothelin-converting enzyme-1 (ECE-1), enables the quantification of ECE-1 activity through its distinctive fluorescence signal. When ECE-1 cleaves this substrate, it releases 7-methoxycoumarin-4-acetyl (Mca), which exhibits excitation and emission maxima at 328 nm and 420 nm, respectively, allowing for the direct measurement of enzyme activity.
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            3-6 months
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