Antibacterial

Antibacterial agent 26 is an antimicrobial compound that is a potent DHFR inhibitor (S. aureus DHFR Ki of 0.020 nM).

Antibacterial agent 131 is a compound with antibacterial properties.

Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis.

Dermaseptin acetate, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration[1].

IMPDH2-IN-2 is a potent inhibitor of inosine 5'-monophosphate dehydrogenase (IMPDH) (Ki,app: 14 μM) and a potential anti-tuberculosis agent, exhibiting moderate antibacterial effects with MIC values of 6.3 and 11 μM in minimal GAST Fe and rich 7H9 ADC Tween media, respectively.

timcodar is a non-FKBP12 binding macrolide derivative that is an efflux pump inhibitor with antimicrobial activity, inhibition of lipid accumulation, inhibition of Mycobacterium tuberculosis, and can be used in the study of obesity. timcodar is a non-FKBP12 binding macrolide derivative with antimicrobial activity.

Procodazole (2-Benzimidazolepropionic acid) is a non-specific active immunoprotective agent against viral and bacterial infections.

Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections.

Phenothiazine (ENT 38) is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis.

Chlorobutanol (Chlortran) is a chemical preservative, sedative hypnotic and weak local anaesthetic. It has Antibacterial and Antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long-term stability to multi-ingredient formulations.

Netilmicin sulfate (Netromycin) is an aminoglycoside antibiotic.

D-Cysteine, the D-isomer of cysteine, is a powerful inhibitor of E. coli growth and is mediated by D-amino acid oxidase to produce H2S, serving as a neuroprotective agent against cerebellar ataxia. Additionally, D-cysteine can inhibit the growth and cariogenicity of a two-species biofilm formed by Streptococcus mutans and Streptococcus hemoglobin.

Clofoctol is a bacteriostatic antibiotic with activity against Gram-positive bacteria, used in the treatment of upper and lower respiratory tract infections.

Nitrofurantoin (Furadantine), an antibiotic, inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections.

Chitosan (MW 150000) (Deacetylated chitin) is a linear polysaccharide made up of randomly distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine.

1,3-Dithiane (1,3-Dithian) is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon. 1,3-Dithiane is also a sulfur-containing Maillard reaction products found in boiled beef extracts.

Benzoylacetone (AI3 10572) exhibits antibacterial activity.

Thiobarbituric acid (NSC-4733) has Antibacterial Activity.

Meldrum's acid (Isopropylidene malonate) is an antimicrobial agent used in deodorant. Meldrum's acid-based multicomponent reaction is a potential tool to prepare novel polymers.

trans-Cinnamic acid (Myricitrine) exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro.

Gamithromycin (ML-1709460) is a macrolide compound with antibacterial activity.

Thymol, also known as Pseudoaspidin, is a principal monoterpene phenol found in the essential oils of plants from the Lamiaceae family, along with several other families including Verbenaceae, Scrophulariaceae, Ranunculaceae, and Apiaceae. This compound exhibits antioxidant, anti-inflammatory, antibacterial, and antifungal properties.

1. Lutein (Xantofyl) has antitumour action. 2. Lutein has antimutagenic action. 3. Lutein has a wide range of antimicrobial action. 4. Lutein is potentially useful for treating macular degeneration.

1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV AIDS. 3. Berberine seems to act as an herbal antidepressant and a neuroprotector against neurodegenerative disorders. 4. Berberine is used in histology for staining heparin in mast cells. As a natural dye, berberine has a colour index of 7516. 5. Berberine reduces hepatic fat content in rats with nonalcoholic fatty liver disease; also prevents proliferation of hepatic stellate cells (HSCs), which are central for the development of fibrosis during liver injury. 6. Berberine can ameliorate proinflammatory cytokines-induced intestinal epithelial tight junction damage in vitro, and berberine may be one of the targeted therapeutic agents that can restore barrier function in intestinal disease states. 7. Berberine has antineoplastic effects, including breast cancer, leukemia, melanoma, epidermoid carcinoma, hepatoma, pancreatic cancer, oral carcinoma, tongue carcinoma, glioblastoma, prostate carcinoma and gastric carcinoma, etc.