αmβ2

Vinclozolin M2, an active metabolite of vinclozolin, is generated through successive esterase activity and decarboxylation in C. elegans, as well as decarboxylation in human liver microsomes. It functions as an antagonist to the mineralocorticoid (IC50= 1,400 nM) and androgen receptors (IC50= 0.17 nM), demonstrated in reporter assays with MCF-7 cells. This compound is exclusively sold for research and analytical purposes, tailored for controlled laboratory use, and is not available in bulk sizes.

M2 ion channel blocker ,Antiviral agent, is capable of inhibiting and blocking the activity of M2 ion channel.

Aflatoxin M2 is a major metabolite of Aflatoxin B1 and is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.

Compound 43, known as M1/M2/M4 muscarinic agonist 2, functions as an mAChR M1/M2/M4 agonist with respective EC50 values of 30 nM, 200 nM, and 6.2 nM.

M2 ion channel blocker-2 (Compound 10) is an inhibitor of the M2 ion channel. It effectively blocks both the wild type and mutant M2 (L27F and V27A) ion channels. This compound exhibits potent antiviral activity against HCoV-229E, with an EC50 of 4.7 μM for cytopathic effect, but shows no efficacy against influenza A virus. Additionally, M2 ion channel blocker-2 does not significantly inhibit hERG or cytochrome P450 enzymes (CYP1A2, CYP2C19, and CYP3A4).

Oltipraz metabolite M2 is the active metabolite of Oltipraz and acts as an orally effective HIF-1α inhibitor. In a high-fat diet mouse model, it enhances mitochondrial fuel oxidation and suppresses hepatic lipogenesis by dual activation of AMPK. Oltipraz metabolite M2 is applicable for research in hepatic steatosis and fatty liver disease.

Dacomitinib metabolite M2 is also known as Dacomitinib cysteine conjugate. Dacomitinib inhibits both the wild-type (WT) EGFR and EGFR T790M.

Antibiotic MA 144M2 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.

Compound 42, also known as M1/M2/M4 muscarinic agonist 1, is a muscarinic M4/M1/M2 agonist exhibiting EC50 values of 6.5, 26, and 210 nM for M4, M1, and M2 respectively. This compound is utilized in research focused on mental disorders, including schizophrenia and delusion [1].

Muscarinic agonist 3 (compound 45) is a muscarinic mAChR M1/M2/M4 agonist with EC50 values of 3.2 nM, 32 nM, and 1.7 nM, respectively [1].

MMT3-72-M2, an MMT3-72 metabolite, is a selective JAK1 inhibitor that inhibits JAK1, JAK2, TYK2, and JAK3 with IC50 values of 10.8 nM, 26.3 nM, 91.6 nM, and 328.7 nM, respectively [1].

U-[13C17]-Aflatoxin M2 in Acetonitrile (Standard) is a fully 13C isotope-labeled aflatoxin M2 solution that can be used as an analytical standard for the determination of aflatoxin M2 in samples.

Landiolol Metabolite M2-13C4 (Standard) is a reference standard of Landiolol Metabolite M2-[13C4] intended for quantitative analysis, quality control, and related biochemical research applications.

Regorafenib Metabolite M2-[13C, D3] (N-Oxide) (Standard) is a reference standard of Regorafenib Metabolite M2-[13C, D3] (N-Oxide) intended for quantitative analysis, quality control, and related biochemical research applications.

Neoenactin M2 exhibits strong antifungal activity against yeasts and filamentous fungi.

Gomisin M2 is an anti-HIV agent.

M2 Peptide is a targeting peptide specific to M2-like tumor-associated macrophages (TAMs). It serves as a carrier for drugs or small interfering RNA (siRNA) to facilitate the repolarization of M2-like macrophages to M1-like macrophages. This shift alters the immunosuppressive state within the tumor microenvironment, enhancing the antitumor immune response. M2 Peptide is used in research to study its effects on macrophage polarization and the implications of this polarization on tumor growth and metastasis.

Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.

αMβ2integrinagonist-1 (Compound 8) is a highly selective αMβ2 integrin agonist with anti-inflammatory properties (EC50=1.4 nM). It activates integrin-mediated cell adhesion and the JNK/ERK signaling pathway. Additionally, αMβ2integrinagonist-1 induces polarization of tumor-associated macrophages and enhances antitumor T-cell immune responses. This compound holds potential for research in cancer and chronic inflammatory diseases such as pancreatic cancer and rheumatoid arthritis.

SCH 57790 is a novel and selective muscarinic M(2) receptor antagonist that releases acetylcholine and enhances cognition in experimental animals for the treatment of Alzheimer's disease.

Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.

Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.

M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM) and also exhibits anti-tumor activity. Additionally, M2N12 shows promising activity against Cdc25A (IC50 = 0.53 μM) and Cdc25B (IC50 = 1.39 μM).

KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).