b2

B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease

Madurastatin B2 is a useful organic compound for research related to life sciences. The catalog number is T124249 and the CAS number is 768384-52-7.

Dracoflavan B2 is a useful organic compound for research related to life sciences and the catalog number is T125453.

Calystegine B2 is a useful organic compound for research related to life sciences and the catalog number is T126111.

Wistariasaponin B2 is a useful organic compound for research related to life sciences. The catalog number is T126123 and the CAS number is 126594-46-5.

Plipastatin B2 is a useful organic compound for research related to life sciences. The catalog number is T126496 and the CAS number is 103955-74-4.

Fumonisin B2 is a mycotoxin produced by Fusarium moniliforme in various grains. It also is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase). Which disrupts de novo sphingolipid biosynthesis.

Hydrolyzed Fumonisin B2 (HFB2) is a hydrolysis product of fumonisins (HF) that retains biological activity and exhibits phytotoxicity.

Polymyxin B2 is an antibiotic primarily utilized for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa.

Clostomycin B2 is a bioactive chemical.

Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Aliment.31(4-6)607-615(1977) 2.Chen, B., Li, D., Li, M., et al.Induction of mitochondria-mediated apoptosis and PI3K/Akt/mTOR-mediated autophagy by aflatoxin B2 in hepatocytes of broilersOncotarget7(51)84989-84998(2016) 3.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogsCancer Res.31(12)1936-1942(1971)

Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3 |1. Yeh, S.F., Pan, W., Ong, G.-T., et al. Study of structure-activity correlation in destruxins, a class of cyclodepsipeptides possessing suppressive effect on the generation of hepatitis B virus surface antigen in human hepatoma cells. Biochem. Biophys. Res. Commun. 229(1), 65-72 (1996).|2. Male, K.B., Tzeng, Y.-M., Montes, J., et al. Probing inhibitory effects of destruxins from Metarhizium anisopliae using insect cell based impedance spectroscopy: Inhibition vs chemical structure. Analyst 134(7), 1447-1452 (2009).|3. Buchwaldt, L., and Green, H. Phytotoxicity of destruxin B and its possible role in the pathogenesis of Alternaria brassicae. Plant Pathol. 41(1), 55-63 (1992).

Prostaglandin B2 (PGB2) is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 ug/kg). [1]

Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 μM) induces differentiation of B16 melanoma cells, with potentiation of expressions of tyr

Thromboxane B2 (a prostaglandin derivative released during anaphylaxis) induces platelet aggregation and arterial contraction.

Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway.

Galanin-B2 (NAX-5055) demonstrates activity in epilepsy models and possesses the ability to penetrate the blood-brain barrier [1].

Cinnamtannin B2 (compound 12), a tannin derivative found in cinnamon, has been isolated from the plant Vaccinium vitis-idaea L. [1].

Alternaphenol B2, a selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1m), is sourced from the coral-derived fungus Parengyodontium album SCSIO SX7W11. It exhibits inhibitory activity specifically against the IDH1 R132H mutation, with an IC50 of 41.9 μM [1].

Polymyxin B2, a significant component of polymyxin B, is an antibiotic cationic lipopeptide initially derived from B. polymyxa. This compound effectively inhibits P. aeruginosa, A. baumannii, K. pneumoniae, and E. cloacae strains, exhibiting minimum inhibitory concentrations (MICs) of 1-2, 0.5-1, 0.25-0.5, and 0.25-1 µg/ml, respectively. Notably, in a mouse model of P. aeruginosa bloodstream infection, administration of polymyxin B2 at a dosage of 4 mg/kg has been shown to decrease the number of colony-forming units (CFUs) in the blood.

Thromboxane B2 (TXB2) is a compound significantly released from aggregating platelets and undergoes metabolic transformation during circulation into 11-dehydro TXB2 and 2,3-dinor TXB2. The latter, 2,3-dinor TXB2, serves as a prevalent urinary metabolite of TXB2 and acts as an indicator for in vivo TXA2 synthesis. Studies have shown that in healthy male volunteers, the median excretion rate of 2,3-dinor TXB2 is measured at 10.3 ng/hour, equivalent to 138 pg/mg of creatinine.

11-Dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite derived from the inactive TXA2 metabolite, TXB2. Its formation involves the action of cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation processes. Remarkably, levels of 11-dehydro-2,3-dinor TXB2 have been observed to increase by 5.2-fold in a surgery-induced rat model of tendon overuse, highlighting its potential role in physiological stress responses.

Ilexsaponin B2 is a natural product for research related to life sciences. The catalog number is TJS0502 and the CAS number is 108906-69-0.

Cassiaside B2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A).Cassiaside B2 is an agonist of the 5-HT2C receptor with anti-allergic activity.Cassiaside B2 is one of the active ingredients in the naphthylpyrone reference extract (NRE).