epi

Epirubicin (4'-Epidoxorubicin) is an anthracycline antibiotic that acts as a Topoisomerase II inhibitor. It exerts its antitumor effects by intercalating into DNA base pairs, inhibiting DNA replication and transcription, and inducing DNA strand breaks/apoptosis. Epirubicin is widely used in the treatment of breast, gastric, lung, and ovarian cancers.

EPI-589, a quinone derivative and oxidoreductase enzyme inhibitor, is considered safe and well tolerated, showing promise for the treatment of amyotrophic lateral sclerosis (ALS).

8-epi-Chlorajapolide F is a useful organic compound for research related to life sciences and the catalog number is T124075.

3-Epi-beta-amyrin is a useful organic compound for research related to life sciences. The catalog number is T124413 and the CAS number is 6811-63-8.

3-Epi-alpha-amyrin is a useful organic compound for research related to life sciences. The catalog number is T124591 and the CAS number is 5937-48-4.

Epi-Cryptoacetalide is a useful organic compound for research related to life sciences and the catalog number is T126054.

7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is a docetaxel impurity identified by HPLC.

epi-D-Captopril (epi-D-SQ 14225) is a stereoisomer of Captopril and functions as an inhibitor of metallo-beta-lactamases (MBLs). The IC50 values of epi-D-Captopril for NDM-1, IMP-1, and VIM-2 are 64 μM, 173 μM, and 5.5 μM, respectively. This compound holds potential for research in MBLs-related antibiotic-resistant infections.

4'-epi-Daunorubicin is the semisynthetic precursor to Epirubicin and functions as an antitumor agent.

6-epi-COTC is a diastereomer of a metabolite produced by Streptomyces, exhibiting anticancer activity.

4-Demethoxy-7,9-di-epi-daunorubicin is a derivative of Daunorubicin and an anthracycline antibiotic (antibiotics). It binds to calf thymus DNA, forming a complex with stacked DNA base pairs. This compound inhibits nucleic acid polymerases in prokaryotes, including Escherichia coli DNA polymerase I (DNA polymerase I) and RNA polymerase (RNA polymerase). 4-Demethoxy-7,9-di-epi-daunorubicin is utilized in cancer and infection research.

Chlortetracycline is an analog of tetracycline , a broad spectrum antibiotic. In addition to its actions against microorganisms, chlortetracycline suppresses inflammation by inhibiting neutrophil action and other aspects of the innate immune response. 4-epi-Chlortetracycline is an epimer of chlortetracycline.

1α-Hydroxy-3-epi-vitamin D3, a natural metabolite derived from 1alpha,25-dihydroxyvitamin D3, effectively suppresses parathyroid hormone (PTH) secretion [1].

7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1 , which contains a 7(R) hydroxyl group. It can be used as an experimental negative control.

Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM). 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.

5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin.

EPI-7170 is a ralaniten analogue and a potent antagonist of the androgen receptor N-terminal structural domain, blocking the transcriptional activity of the full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170 exhibits antitumor activity against enzalutamide resistant debulking resistant prostate cancer (CRPC).

EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.

6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, acts as a potent anti-inflammatory agent.

3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM in U87MG cells.

7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) is an endogenous androgenic derivative of dehydroepiandrosterone that binds to ERβ and exhibits anti-inflammatory and neuroprotective properties [1] [2] [3].

Epi-Aszonalenin A, a benzodiazepine fungal metabolite initially derived from Aspergillus novofumigatus, functions as a psychoactive agent [1].

23-epi-26-Deoxyactein is a naturally occurring compound with demonstrated anti-obesity and anti-cancer properties when administered orally [1][2][3].

11-epi-Chaetomugilin I, a metabolite identified in Chaetomium globosum, demonstrates notable cytotoxic activity against several cell lines, including the murine P388 and L1210 leukemia cell lines, the human HL-60 leukemia cell line, and the human KB epidermoid carcinoma cell line [1].