epi

Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, acts as an antineoplastic agent by inhibiting Topoisomerase, thus impeding DNA and RNA synthesis. Additionally, it functions as a Forkhead box protein p3 (Foxp3) inhibitor, curbing regulatory T cell activity.

EPI-589, a quinone derivative and oxidoreductase enzyme inhibitor, is considered safe and well tolerated, showing promise for the treatment of amyotrophic lateral sclerosis (ALS).

8-epi-Chlorajapolide F is a useful organic compound for research related to life sciences and the catalog number is T124075.

18-Beta-hydroxy-3-epi-alpha-yohimbine is a useful organic compound for research related to life sciences and the catalog number is T124173.

3-Epi-beta-amyrin is a useful organic compound for research related to life sciences. The catalog number is T124413 and the CAS number is 6811-63-8.

3-Epi-alpha-amyrin is a useful organic compound for research related to life sciences. The catalog number is T124591 and the CAS number is 5937-48-4.

15-Epi-Danshenol-A is a useful organic compound for research related to life sciences and the catalog number is T125334.

Epi-Cryptoacetalide is a useful organic compound for research related to life sciences and the catalog number is T126054.

Isopropyl-epi-isoobacunoate is a useful organic compound for research related to life sciences and the catalog number is T131516.

7-Epi-paradisiol is a useful organic compound for research related to life sciences and the catalog number is T131585.

Epi-galantamine, a diastereomer of galantamine, is an alkaloid extracted from the bulbs and flowers of the Caucasian snowdrop (Galanthus woronowii). It acts as an AChE inhibitor, featuring an EC50 of 45.7 μM.

7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is a docetaxel impurity identified by HPLC.

3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3. Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.

Chlortetracycline is an analog of tetracycline , a broad spectrum antibiotic. In addition to its actions against microorganisms, chlortetracycline suppresses inflammation by inhibiting neutrophil action and other aspects of the innate immune response. 4-epi-Chlortetracycline is an epimer of chlortetracycline.

1α-Hydroxy-3-epi-vitamin D3, a natural metabolite derived from 1alpha,25-dihydroxyvitamin D3, effectively suppresses parathyroid hormone (PTH) secretion [1].

7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1 , which contains a 7(R) hydroxyl group. It can be used as an experimental negative control.

13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn. ω-3 and ω-6 polyunsaturated fatty acids in plants are substrates for plant lipoxygenases. 12-oxo PDA is one of the best studied end metabolites of this enzymatic pathway. While the initial enzymatic product and major isomer of 12-oxo PDA contains side chains in the cis position, both being β to the ring, the upper side chain attached at C-13, can and frequently does, isomerize when 12-oxo PDA is extracted, isolated, or stored. 13-epi-12-oxo PDA is the product of this isomerization.

Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM). 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.

11-epi-mogroside V, a compound found in the fruit of Siraitia grosvenori, possesses significant bioactivity by enhancing glucose uptake in vitro, specifically in human HepG2 cells.

1. 7-epi-Taxol (7-Epitaxol) is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.

5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin.

7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.

EPI-7170 is a ralaniten analogue and a potent antagonist of the androgen receptor N-terminal structural domain, blocking the transcriptional activity of the full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170 exhibits antitumor activity against enzalutamide resistant debulking resistant prostate cancer (CRPC).

EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.