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epi-Inositol

Name: epi-Inositol
Brand: TargetMol
SKU: T77206
Rating: 4.5 (1 reviews)

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Catalog No. T77206 Copy Product Info

Purity: 99.95%

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epi-Inositol, an inositol analog, has antidepressant activity and modulates the expression of key regulatory genes in the inositol biosynthesis pathway, as well as displaying anticonvulsant effects.

Cas No. 488-58-4

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Purity:99.95%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	epi-Inositol, an inositol analog, has antidepressant activity and modulates the expression of key regulatory genes in the inositol biosynthesis pathway, as well as displaying anticonvulsant effects.
In vitro	Methods: epi-Inositol was applied in a yeast system for treatment alone or in combination with lithium or valproic acid, and its effect on the expression level of the INO1 gene (encoding inositol-1-P synthase) was detected. Results: : 1.epi-Inositol is involved in the regulation of INO1 gene expression in yeast. 2.epi-Inositol can significantly reduce the basal expression level of the INO1 gene. 3.epi-Inositol is able to reverse the upregulation of INO1 gene expression induced by lithium or valproic acid [1].
In vivo	Methods: epi-Inositol was administered via intracerebroventricular injection, and its effect on the rat seizure model induced by Lithium-Pilocarpine was observed. Results: epi-Inositol (10 mg/40 μL, intracerebroventricular injection) could effectively reverse lithium-pilocarpine-induced seizures in rats [2].

Chemical Properties

Molecular Weight	180.16
Formula	C₆H₁₂O₆
Cas No.	488-58-4
Smiles	O[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@@H]1O

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 66.66 mg/mL (370.00 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: epi-Inositol chemical structure | epi-Inositol in vivo | epi-Inositol in vitro | epi-Inositol formula | epi-Inositol molecular weight