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Microbiology/Virology

Penicillin-binding protein (PBP)

(2)

RSV

(41)

Reverse Transcriptase

Beta-lactamase

Beta-lactamase is an enzyme produced by certain bacteria that provides resistance to beta-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems. These antibiotics contain a beta-lactam ring, which is essential for their antibacterial activity. Beta-lactamase catalyzes the hydrolysis of the beta-lactam ring, rendering the antibiotic inactive and allowing bacteria to survive.

Filter HomeSignaling PathwaysMicrobiology/VirologyBeta-lactamase

PhoPS

T204726

PhoPS is a photoactivatable β-lactamase inhibitor. Upon exposure to light, PhoPS releases the active β-lactamase inhibitor Sulbactam. This compound is capable of inhibiting the synthesis of bacterial cell walls and the formation of biofilms in Escherichia coli, thereby exhibiting antibacterial activity.

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Piperacillin hydrate

T20441866258-76-2

Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic. It exhibits potent bactericidal activity against Gram-negative bacteria and some Gram-positive bacteria by targeting penicillin-binding proteins. Piperacillin hydrate is frequently combined with the β-lactamase inhibitor Tazobactam for enhanced efficacy.

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10-14 weeks

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Metallo-β-lactamase-IN-16

T2010212058069-25-1

Metallo-β-lactamase-IN-16 (compound 18), a sulfone-containing metallo-β-lactamase inhibitor, exhibits antimicrobial activity. It effectively inhibits various metallo-β-lactamases, including NDM-1 (New Delhi metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona Integron-encoded Metallo-β-lactamase), and VIM-2. The IC50 values for these enzymes are 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM respectively.

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3-6 months

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NDM-1 inhibitor-8

T204912

NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.

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Doxazosin impurity 12

T2042822066-93-5

Doxazosin impurity 12 acts as an inhibitor of CTX-M β-lactamase (Beta-lactamase) with a Ki value of 0.7 mM against CTX-M.

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10-14 weeks

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Xeruborbactam isoboxil

T2051682708983-65-5

Xeruborbactam isoboxil is a β-lactamase (beta-lactamase) inhibitor.

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10-14 weeks

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NDM-1 inhibitor-7

T20555626151-73-5

NDM-1 inhibitor-7 (Compound A8) is an NDM-1 inhibitor with an IC50 of 10.284 μM. It restores the ability of meropenem (MEM) to penetrate the cell wall of Gram-negative bacteria and effectively reinstates MEM's antibacterial activity against NDM-1 positive Escherichia coli. Moreover, NDM-1 inhibitor-7 demonstrates significant efficacy in both Galleria mellonella and murine peritonitis infection models.

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10-14 weeks

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