Antibiotic

FR 900261, Antibiotic WF 3161 is a useful organic compound for research related to life sciences. The catalog number is T124069 and the CAS number is 86402-37-1.

Antibiotic PF 1018 is a useful organic compound for research related to life sciences and the catalog number is T126064.

Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10 and 20 μM.References Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10 and 20 μM. References

Antibiotic JI 20A is a bioactive chemical.

Antibiotic LL-D253alpha is a useful organic compound for research related to life sciences. The catalog number is T123925 and the CAS number is 92589-99-6.

Antibiotic SB 202742 is a useful organic compound for research related to life sciences. The catalog number is T124135 and the CAS number is 83173-24-4.

Antibiotic F01-1358B is a useful organic compound for research related to life sciences. The catalog number is T126422 and the CAS number is 1095602-46-2.

Antibiotic LL-P880y is a useful organic compound for research related to life sciences. The catalog number is T124885 and the CAS number is 41206-21-7.

Antibiotic Sch 378167 is a useful organic compound for research related to life sciences. The catalog number is T125021 and the CAS number is 336108-99-7.

Antibiotic FF 8181A is a useful organic compound for research related to life sciences. The catalog number is T125547 and the CAS number is 179118-87-7.

Antibiotic OM 173?2 is a useful organic compound for research related to life sciences. The catalog number is T124003 and the CAS number is 88293-10-1.

Antibiotic ZG 1494alpha is a useful organic compound for research related to life sciences and the catalog number is T125528.

Antibiotic AB 4063B is a useful organic compound for research related to life sciences and the catalog number is T125699.

Antibiotic TAN 1446A is a useful organic compound for research related to life sciences. The catalog number is T125813 and the CAS number is 148084-27-9.

Antibiotic WB is a useful organic compound for research related to life sciences. The catalog number is T125208 and the CAS number is 247919-66-0.

Antibiotic Sch 60057 is a useful organic compound for research related to life sciences. The catalog number is T125403 and the CAS number is 203061-35-2.

Antibiotic AGI-B4 is a useful organic compound for research related to life sciences. The catalog number is T124954 and the CAS number is 359828-18-5.

Antibiotic Sch 60065 is a useful organic compound for research related to life sciences. The catalog number is T125405 and the CAS number is 203061-31-8.

Antibiotic JBIR 27 is a useful organic compound for research related to life sciences. The catalog number is T126295 and the CAS number is 1172094-65-3.

Antibiotic JM 971B is a useful organic compound for research related to life sciences. The catalog number is T123922 and the CAS number is 92802-16-9.

Antibiotic ES 242-3 is a useful organic compound for research related to life sciences. The catalog number is T125981 and the CAS number is 136565-68-9.

Antibiotic NFAT 133 is a useful organic compound for research related to life sciences. The catalog number is T125647 and the CAS number is 165133-85-7.

Antibiotic F 1839A is a useful organic compound for research related to life sciences. The catalog number is T125708 and the CAS number is 159096-43-2.

Antibiotic LL-D253gamma is a useful organic compound for research related to life sciences. The catalog number is T125005 and the CAS number is 34288-35-2.

Antibiotic Sch 60061 is a useful organic compound for research related to life sciences. The catalog number is T125404 and the CAS number is 203061-33-0.

Antibiotic L 783277 is a useful organic compound for research related to life sciences. The catalog number is T124209 and the CAS number is 791807-02-8.

Antibiotic NK-A 17E-233I is a useful organic compound for research related to life sciences. The catalog number is T126331 and the CAS number is 115103-30-5.

Antibiotic Sch 60059 is a useful organic compound for research related to life sciences. The catalog number is T125406 and the CAS number is 203061-30-7.

Antibiotic LL-Z1640-6 is a useful organic compound for research related to life sciences. The catalog number is T124451 and the CAS number is 66018-43-7.

Antibiotic XR 586 is a useful organic compound for research related to life sciences. The catalog number is T125507 and the CAS number is 185981-24-2.

Antibiotic AB 4015B is a useful organic compound for research related to life sciences and the catalog number is T125657.

Antibiotic 2158 is a useful organic compound for research related to life sciences and the catalog number is T125527.

Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6 15 2 3 3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.

K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively).

Teicoplanin (MDL-507) is a semisynthetic glycopeptide antibiotic, used to treat Gram-positive bacteria.

Midecamycin (Medecamycin A1), an acetoxy-substituted macrolide antibiotic, has effective on gram-positive and gram-negative bacteria acts by inhibiting bacterial protein synthesis.

Carubicin is an anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.

Lankacidins is an antitumor antibiotic of the macrolide tetraenes family from Streptomyces.

EM 5519 is an antitumor antibiotic.

Parvodicin C2, a glycopeptide antibiotic derived from A. parvosata and part of the parvodicin complex, serves as a component of the A40926 antibiotic complex utilized as a precursor for synthesizing dalbavancin. It exhibits activity against methicillin-sensitive and methicillin-resistant strains of S. aureus, S. epidermidis, S. saprophyticus, S. hemolyticus, and E. faecalis.

Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration.

Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the treatment of malaria and rheumatoid arthritis. Chloroquine also has anti-SARS-CoV-2 (COVID-19) activity and anti-HIV-1 activity.

Concanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection.

Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.

Albofungin is a xanthone isolated from A. tumemacerans.

Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (1 μM) inhibits cytokine expression and nitric oxide production induced by LPS.[3] Nargenicin (200 μM), when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid , reduces cell proliferation by 37-47% and increases cell differentiation by 82-85% in HL-60 human myeloid leukemia cells.[4]

A 201A is a nucleoside antibiotic, it is isolated from Streptomyces capreolus.

Kazusamycin A is a new antitumor antibiotic.

K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.

Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.