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(Rac)-Moxifloxacin

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Catalog No. TYD-04751Cas No. 354812-41-2
Alias (Rac)-BAY 12-8039 free base

(Rac)-Moxifloxacin ((Rac)-BAY 12-8039 free base) is an isomer of Moxifloxacin Hydrochloride. Moxifloxacin Hydrochloride (BAY 12-8039) is an orally effective 8-methoxyquinolone antibacterial agent used in studies on acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and infectious pneumonia.

(Rac)-Moxifloxacin
Other Forms of (Rac)-Moxifloxacin:

(Rac)-Moxifloxacin

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Catalog No. TYD-04751Alias (Rac)-BAY 12-8039 free baseCas No. 354812-41-2
(Rac)-Moxifloxacin ((Rac)-BAY 12-8039 free base) is an isomer of Moxifloxacin Hydrochloride. Moxifloxacin Hydrochloride (BAY 12-8039) is an orally effective 8-methoxyquinolone antibacterial agent used in studies on acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and infectious pneumonia.
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Product Introduction

Bioactivity
Description
(Rac)-Moxifloxacin ((Rac)-BAY 12-8039 free base) is an isomer of Moxifloxacin Hydrochloride. Moxifloxacin Hydrochloride (BAY 12-8039) is an orally effective 8-methoxyquinolone antibacterial agent used in studies on acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and infectious pneumonia.
In vitro
Moxifloxacin hydrochloride (BAY 12-8039) was evaluated for its in vitro activity against Listeria monocytogenes using a bone marrow-derived mouse macrophage model. Time-kill curves and intracellular growth inhibition assays compared it with amoxicillin. Moxifloxacin acted more rapidly, beginning its effect within the first 3 hours and achieving complete broth sterilization within 24 hours of incubation. It also seemed to protect macrophages from lysis, as many cells survived after 24 hours of incubation.
In vivo
Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; administered once to three times daily over 7 days; in male Wistar rats) extends survival when administered every 8 hours. Tissue cultures taken 30 hours after bacterial challenge reveal significantly reduced bacterial overgrowth in the spleen and lungs of moxifloxacin-treated animals compared to saline-treated ones, with no observed toxicity.
Synonyms(Rac)-BAY 12-8039 free base
Chemical Properties
Molecular Weight401.43
FormulaC21H24FN3O4
Cas No.354812-41-2
SmilesO=C(O)C1=CN(C2=C(OC)C(=C(F)C=C2C1=O)N3CC4NCCCC4C3)C5CC5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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