complex

MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.

MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).

4'-Methylacetophenone can be used as a fragrance material. It is wildly occurred in volatile compounds in food and in some natural complex substances.

Benproperine phosphate (Pirexyl phosphate) is a cough suppressant.

Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor.

Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other beta-lactam antibiotics by the enzyme. Combining this agent with a beta-lactamase susceptible antibiotic, such as penicillins or a cephalosporin, to treat infections caused by beta-lactamase producing organisms, results in a decreased turnover rate of the beta-lactamase sensitive antibiotic and enhances its antibacterial activity.

JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.

Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).

Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.

IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.

Necrosulfonamide ((E)-Necrosulfonamide) is a necroptosis inhibitor that targets MLKL and is selective. Necrosulfonamide prevents the MLKL-RIP1-RIP3 necrosomal complex from interacting with its downstream effectors.

Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blockin

Bc1 Complex-IN-1 (compound 12g) is a potent inhibitor of the bc1 complex, demonstrating fungicidal properties against cucumber downy mildew (CDM).

Pt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic carbene complex 2C) (Compound 2C) is an N-heterocyclic carbene-based platinum (II) complex. This compound acts as an immunogenic cell death (ICD) inducer in liver cancer cells, triggering endoplasmic reticulum stress (ERS) and ROS production, which ultimately leads to the release of damage-associated molecular patterns (DAMPs). Furthermore, it arrests the cell cycle in the S phase and significantly induces apoptosis. In mouse models, Pt(II)-NHC Complex 2C has demonstrated anticancer potential against liver cancer and activated immune cells in liver injury models.

RAS-selective tri-complex inhibitor is an orally effective and novel three-complex RAS (ON)MULTI inhibitor. It is a potent non-covalent inhibitor of multiple RAS variant GTP-bound states. RAS-selective tri-complex inhibitor has anti-tumor activity and can be used in related research on RAS-driven tumors. With our rich experience in compound synthesis, we can provide rapid customized synthesis services for this product according to your research needs.

CypA KRAS G12D Triple Complex Modulator is an effective and orally-active inhibitor of KRAS G12D, capable of inducing apoptosis in KRAS G12D mutant cancer cells. CypA KRAS G12D Triple Complex Modulator holds the potential for researching KRAS G12D mutant cancers.

Complex III-IN-2 (Compd 4d-2) is a complex III inhibitor with antifungal activity, exhibiting EC50 values of 29.31 mg/L against R. solani and 29.98 mg/L against Sclerotinia sclerotiorum [1].

Complex III-IN-1 (Compd 4c-2) is an inhibitor of complex III with antifungal activity, exhibiting an EC50 value of 18.53 mg/L against Sclerotinia sclerotiorum [1].

Nuclear pore complex protein Nup98 (315-360) represents the segment of the nuclear pore complex (NPC) protein ranging from residues 315 to 360.

Trypsin/Lys-C complex protease (MS grade) combines two recombinant proteases, Trypsin and Lys-C, to efficiently hydrolyze peptide bonds. Trypsin specifically cleaves at the C-terminal of arginine (R) and lysine (K), while Lys-C targets the C-terminal of lysine (K). This combination overcomes issues of missed cleavages due to Trypsin's slower digestion at lysine and arginine, PTM alterations on lysine, or hydrophobic C-termini like proline. It is suitable for digesting complex protein samples that are difficult to process enzymatically. This protease is used for protein characterization, single-cell omics, and large-cohort proteomics studies.

Cholic acid-cysteine-cyanuric chloride complex is a hapten linker molecule, consisting of an antigen, cholic acid, and the covalently bonded cyanuric chloride reactive group.

Sulfur trioxide-Triethylamine complex is a Lewis acid-base adduct commonly used as a sulfonating agent or Lewis acid catalyst, widely used in biochemical experiments and drug synthesis research.

Enniatin complex, a mixture of cyclohexadepsipeptides predominantly derived from various Fusarium species of fungi, exhibits inhibitory effects on enzymes such as acyl-CoA: cholesterol acyl transferase. Furthermore, it has demonstrated the ability to induce apoptosis in multiple cancer cell lines. In addition to these activities, the Enniatin complex possesses ionophoric, antibiotic, and in vitro hypolipidemic properties.