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BPK-25

Name: BPK-25
Brand: TargetMol
SKU: T39829
Rating: 4.5 (1 reviews)

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Catalog No. T39829Cas No. 2305052-86-0

Alias BPK25, BPK 25

BPK-25 is an active acrylamide. It can inhibit the activation of TMEM173 by the cyclic dinucleotide ligand cGAMP, suppress the activation of NF-κB, promote nucleosome remodeling, and lead to the degradation of the deacetylated (NuRD) complex proteins.

BPK-25

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Catalog No. T39829Alias BPK25, BPK 25Cas No. 2305052-86-0

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Product Introduction

Bioactivity

Description	BPK-25 is an active acrylamide. It can inhibit the activation of TMEM173 by the cyclic dinucleotide ligand cGAMP, suppress the activation of NF-κB, promote nucleosome remodeling, and lead to the degradation of the deacetylated (NuRD) complex proteins.
In vitro	BPK-25 (10 μM; 5 h) inhibits TMEM173 activation via the cyclic dinucleotide ligand cGAMP [2]. BPK-25 (10 μM; 24 h) suppresses NF-κB activation by blocking nuclear factor of activated T cells (NFAT) activation [1]. BPK-25 (0.1, 1, 5, 10, 20 μM; 24 hours) promotes significant and selective reduction of several proteins in the nucleolar remodeling and deacetylation (NuRD) complex in a concentration- and time-dependent manner. No corresponding changes in BPK-25 mRNA expression were observed [1].
Synonyms	BPK25, BPK 25

Chemical Properties

Molecular Weight	392.84
Formula	C₂₁H₁₇ClN₄O₂
Cas No.	2305052-86-0
Smiles	O=C(C=C)N(C1=CN=C(C=C1)C(=O)NC=2C=CC=CC2)CC3=NC(Cl)=CC=C3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (305.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5456 mL	12.7278 mL	25.4557 mL	127.2783 mL
5 mM	0.5091 mL	2.5456 mL	5.0911 mL	25.4557 mL
10 mM	0.2546 mL	1.2728 mL	2.5456 mL	12.7278 mL
20 mM	0.1273 mL	0.6364 mL	1.2728 mL	6.3639 mL
50 mM	0.0509 mL	0.2546 mL	0.5091 mL	2.5456 mL
100 mM	0.0255 mL	0.1273 mL	0.2546 mL	1.2728 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc