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BPK-25

Name: BPK-25
Brand: TargetMol
SKU: T39829
Price: 145 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39829Cas No. 2305052-86-0

Alias BPK25, BPK 25

BPK-25 is an active acrylamide. It can inhibit the activation of TMEM173 by the cyclic dinucleotide ligand cGAMP, suppress the activation of NF-κB, promote nucleosome remodeling, and lead to the degradation of the deacetylated (NuRD) complex proteins.

BPK-25

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Purity: 99.98%

Catalog No. T39829Alias BPK25, BPK 25Cas No. 2305052-86-0

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$145	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$810	-	In Stock
50 mg	$1,240	-	In Stock
100 mg	$1,990	-	In Stock
1 mL x 10 mM (in DMSO)	$255	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.98%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BPK-25 is an active acrylamide. It can inhibit the activation of TMEM173 by the cyclic dinucleotide ligand cGAMP, suppress the activation of NF-κB, promote nucleosome remodeling, and lead to the degradation of the deacetylated (NuRD) complex proteins.
In vitro	BPK-25 (10 μM; 5 h) inhibits TMEM173 activation via the cyclic dinucleotide ligand cGAMP [2]. BPK-25 (10 μM; 24 h) suppresses NF-κB activation by blocking nuclear factor of activated T cells (NFAT) activation [1]. BPK-25 (0.1, 1, 5, 10, 20 μM; 24 hours) promotes significant and selective reduction of several proteins in the nucleolar remodeling and deacetylation (NuRD) complex in a concentration- and time-dependent manner. No corresponding changes in BPK-25 mRNA expression were observed [1].
Synonyms	BPK25, BPK 25

Chemical Properties

Molecular Weight	392.84
Formula	C₂₁H₁₇ClN₄O₂
Cas No.	2305052-86-0
Smiles	O=C(C=C)N(C1=CN=C(C=C1)C(=O)NC=2C=CC=CC2)CC3=NC(Cl)=CC=C3

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (305.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5456 mL	12.7278 mL	25.4557 mL	127.2783 mL
5 mM	0.5091 mL	2.5456 mL	5.0911 mL	25.4557 mL
10 mM	0.2546 mL	1.2728 mL	2.5456 mL	12.7278 mL
20 mM	0.1273 mL	0.6364 mL	1.2728 mL	6.3639 mL
50 mM	0.0509 mL	0.2546 mL	0.5091 mL	2.5456 mL
100 mM	0.0255 mL	0.1273 mL	0.2546 mL	1.2728 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc