sec

SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].

SEC inhibitor KL-1 (KL-1) is a potent, selective super elongation complex (SEC) inhibitor that exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM) and disrupts the interaction between the SEC scaffolding protein AFF4.

SEC inhibitor KL-2 (KL-2) is a potent and selective inhibitor of the super elongation complex (SEC), showing a dose-dependent inhibitory effect on the AFF4-CCNT1 interaction with a Ki of 1.50 μM.

Sec61-IN-1, a powerful Sec61 inhibitor, impedes the translocation of proteins across the endoplasmic reticulum membrane.

Sec-butyl-CoA,disulfide3 (Sec-butyl-coenzyme A,disulfide3) is a derivative of coenzyme A.

4-sec-Butylphenol is classified as a fatty alcohol organic compound.

Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal Sec-O-Glucosylhamaudol has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor.

5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is one of the impurities of itraconazole, a selective LOX-5 inhibitor.

(S)-(-)-Phenylethanol ((-)-Methyl phenyl carbinol) exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). (S)-(-)-Phenylethanol has been detected in multiple biofluids, such as feces and saliva. Within the cell, (S)-(-)-Phenylethanol is primarily located in the cytoplasm.

Febuxostat sec-butoxy acid is an impurity of Febuxostat, a selective xanthine oxidase inhibitor with a K i of 0.6 nM [1].

Amiterol, a phenylethylamine derivative, is an oral anti-asthmatic compound (bronchodilator).

2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.

m-Di(sec-butyl)benzene is a bioactive chemical.

Valeranilide, 3'-hydroxy-2-methyl-, sec-butylcarbamate (ester) is a bioactive chemical.

Sec61-IN-2 (A3) is a protein secretion inhibitor.

Sec61-IN-2 (A347) is a protein secretion inhibitor. This compound effectively interferes with the Sec61-mediated translocation mechanism, thereby inhibiting the movement of proteins across the endoplasmic reticulum membrane, which disrupts cellular functioning.

6"-apiosyl sec-O-glucosylhamaudol is an aromatic compound exhibiting weak inhibitory activity against SKOV3 (IC50=86 μM).

Sec61-IN-5 (Compound 16c), a Sec61 inhibitor, exhibits cytotoxicity in A549 cells with an IC50 of 0.27 nM and impedes Sec61-dependent secretory function with an IC50 of 0.08 nM [1].

Sec61-IN-4 (Compound 16b) is a potent inhibitor of Sec61, exhibiting an IC50 value of 0.04 nM in U87-MG cells [1].

gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.

Quilseconazole Formic acid is a selective inhibitor of fungal Cyp51 with potent activities against Cryptococcus neoformans and Cryptococcus gattii.

γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.

Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa.

Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein. Insecticidal agent 364 has antitumor activity, and by inhibiting mTOR, Insecticidal agent 364 aims to disrupt signaling pathways involved in cancer cell growth and survival, thereby potentially inhibiting tumor growth.