sec

SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].

SEC inhibitor KL-1 (KL-1) is a potent, selective super elongation complex (SEC) inhibitor that exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM) and disrupts the interaction between the SEC scaffolding protein AFF4.

SEC inhibitor KL-2 (KL-2) is a potent and selective inhibitor of the super elongation complex (SEC), showing a dose-dependent inhibitory effect on the AFF4-CCNT1 interaction with a Ki of 1.50 μM.

Sec61-IN-1, a powerful Sec61 inhibitor, impedes the translocation of proteins across the endoplasmic reticulum membrane.

Sec-butyl-CoA,disulfide3 (Sec-butyl-coenzyme A,disulfide3) is a derivative of coenzyme A.

4-sec-Butylphenol is classified as a fatty alcohol organic compound.

Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal Sec-O-Glucosylhamaudol has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor.

5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is one of the impurities of itraconazole, a selective LOX-5 inhibitor.

(S)-(-)-Phenylethanol ((-)-Methyl phenyl carbinol) exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). (S)-(-)-Phenylethanol has been detected in multiple biofluids, such as feces and saliva. Within the cell, (S)-(-)-Phenylethanol is primarily located in the cytoplasm.

Febuxostat sec-butoxy acid is an impurity of Febuxostat, a selective xanthine oxidase inhibitor with a K i of 0.6 nM [1].

Amiterol, a phenylethylamine derivative, is an oral anti-asthmatic compound (bronchodilator).

2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.

m-Di(sec-butyl)benzene is a bioactive chemical.

Valeranilide, 3'-hydroxy-2-methyl-, sec-butylcarbamate (ester) is a bioactive chemical.

Sec61-IN-2 (A3) is a protein secretion inhibitor.

Sec61-IN-2 (A347) is a protein secretion inhibitor. This compound effectively interferes with the Sec61-mediated translocation mechanism, thereby inhibiting the movement of proteins across the endoplasmic reticulum membrane, which disrupts cellular functioning.

Sec-O-Glucosylhamaudol (Standard) is a reference standard of Sec-O-Glucosylhamaudol intended for quantitative analysis, quality control, and related biochemical research applications.

6"-apiosyl sec-O-glucosylhamaudol is an aromatic compound exhibiting weak inhibitory activity against SKOV3 (IC50=86 μM).

Sec61-IN-5 (Compound 16c), a Sec61 inhibitor, exhibits cytotoxicity in A549 cells with an IC50 of 0.27 nM and impedes Sec61-dependent secretory function with an IC50 of 0.08 nM [1].

Sec61-IN-4 (Compound 16b) is a potent inhibitor of Sec61, exhibiting an IC50 value of 0.04 nM in U87-MG cells [1].

gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.

Quilseconazole Formic acid is a selective inhibitor of fungal Cyp51 with potent activities against Cryptococcus neoformans and Cryptococcus gattii.

γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.

Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa.