TNF β

TNF-α agonistic 1, a TNF-α agonistic compound, could induce cells to secrete TNF- α.

TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.

TNF-α-IN-1 is a TNF-α inhibitor.

TNF-α (31-45), human, is a peptide of tumor necrosis factor-α.

TNF-α-IN-25 exhibits weak to moderate inhibition of the hERG-encoded potassium ion channel, with a hERG IC50 value of 9.2 μM.

TNF-α-IN-26 (Compound 18) is a TNF-α inhibitor, exhibiting an IC50 of 0.10 μM for the CSBP ligand. It suppresses LPS-stimulated TNF production in mouse models and is applicable in research on inflammatory diseases.

TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.

TNF-α-IN-6 is an orally efficacious, allosteric inhibitor of TNFα (K_D = 6.8 nM).

TNF-α (31-45), human (TFA), is a peptide of tumor necrosis factor-α (TNF alpha), an inflammatory cytokine that induces necrosis or apoptosis.

TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a dissociation constant (K D) of 12.06 μM. It impedes TNF-α-induced caspase activation and the NF-κB signaling pathway by binding to TNF-α, suppressing the phosphorylation of IκBα and the nuclear migration of NF-κB p65. This compound is utilized in the study of TNF-α-mediated autoimmune diseases [1].

TNF-α-IN-10 (compound 8a) is an inhibitor of IL-6 and TNF-α, exhibiting anti-inflammatory activity [1].

TNF-α-IN-18 (Compound 61) is a small molecule inhibitor of tumor necrosis factor-alpha (TNF-α) that operates with a IC50 of 1.8µM. TNF-α-IN-18 effectively blocks the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), thereby suppressing the downstream TNF signaling pathway; TNF-α-IN-18 exhibits minimal cytotoxicity in mouse fibroblast LM cells with a CC50 greater than 50 µM. TNF-α-IN-18has been shown to alleviate sepsis induced by TNF or lipopolysaccharide in mouse models, and provides significant protection against the development and progression of rheumatoid arthritis in murine models.

TNF-α-IN-22 (Compound 30) is a TNFα inhibitor that induces apoptosis by inhibiting TNFα-induced IkBα downregulation and blocking the cell cycle. It is applicable for research in triple-negative breast cancer.

TNF-α-IN-24 (Example 15) is a TNF-α inhibitor with an IC50 value of 4.1 nM. It is applicable in research on inflammatory and autoimmune diseases such as rheumatoid arthritis and Crohn's disease.

TNF-alpha-IN-1 (compound 202) is an orally active TNF-alpha inhibitor. This compound possesses anti-inflammatory properties and is applicable in research related to rheumatoid arthritis, psoriasis, and asthma.

TNF-α-IN-8 (compound I-42) is an isoindole-imide inhibitor of tumor necrosis factor-alpha (TNF-α), used in research on cancer, heart disease, osteoporosis, and autoimmune disorders. It also acts as a click chemistry reagent, with an Azide group suitable for CuAAc or SPAAC reactions with Alkyne, DBCO, or BCN groups.

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) is a peptide used as a fluorescence resonance energy transfer (FRET) based substrate for proteolytic activity assays, with cleavage-induced changes in fluorescence intensity indicating enzymatic activity [1].

Anti-Fibronectin Antibody (L19-TNF) is a human-derived antibody expressed in CHO cells, specifically targeting Fibronectin. It has a huIgG1 heavy chain and a huκ light chain, with an estimated molecular weight (MW) of 144.14 kDa. For its isotype control, please refer to HumanIgG4kappa, Isotype Control.

TNF-α (10-36), human, is a potent pro-inflammatory cytokine involved in the acute phase stress response.

Human TNF alpha (46-65) peptide.

TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).

Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.

Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac, and central nervous system stimulant activities. It inhibits the 3', 5'-cyclic nucleotide phosphodiesterase that degrades cyclic AMP, thus potentiating the actions of agents that act through adenylyl cyclases and cyclic AMP.

R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist that exhibits heightened selectivity for TNFα.