TNF β

TNF-α agonistic 1, a TNF-α agonistic compound, could induce cells to secrete TNF- α.

TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.

TNF-α-IN-1 is a TNF-α inhibitor.

TNF-α (31-45), human, is a peptide of tumor necrosis factor-α.

TNF-α-IN-22 (Compound 30) is a TNFα inhibitor that induces apoptosis by inhibiting TNFα-induced IkBα downregulation and blocking the cell cycle. It is applicable for research in triple-negative breast cancer.

TNF-α-IN-24 (Example 15) is a TNF-α inhibitor with an IC50 value of 4.1 nM. It is applicable in research on inflammatory and autoimmune diseases such as rheumatoid arthritis and Crohn's disease.

TNF-α-IN-25 exhibits weak to moderate inhibition of the hERG-encoded potassium ion channel, with a hERG IC50 value of 9.2 μM.

TNF-α-IN-26 (Compound 18) is a TNF-α inhibitor, exhibiting an IC50 of 0.10 μM for the CSBP ligand. It suppresses LPS-stimulated TNF production in mouse models and is applicable in research on inflammatory diseases.

TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.

TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.

TNF-α-IN-6 is an orally efficacious, allosteric inhibitor of TNFα (K_D = 6.8 nM).

TNF-α (31-45), human (TFA), is a peptide of tumor necrosis factor-α (TNF alpha), an inflammatory cytokine that induces necrosis or apoptosis.

TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.

Anti-Mouse TNF alpha Antibody (TN3-19.12) is a mouse-derived IgG antibody against TNF alpha.

TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a dissociation constant (K D) of 12.06 μM. It impedes TNF-α-induced caspase activation and the NF-κB signaling pathway by binding to TNF-α, suppressing the phosphorylation of IκBα and the nuclear migration of NF-κB p65. This compound is utilized in the study of TNF-α-mediated autoimmune diseases [1].

TNF-α-IN-10 (compound 8a) is an inhibitor of IL-6 and TNF-α, exhibiting anti-inflammatory activity [1].

TNF-α-IN-18 (Compound 61) is a small molecule inhibitor of tumor necrosis factor-alpha (TNF-α) that operates with a IC50 of 1.8µM. TNF-α-IN-18 effectively blocks the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), thereby suppressing the downstream TNF signaling pathway; TNF-α-IN-18 exhibits minimal cytotoxicity in mouse fibroblast LM cells with a CC50 greater than 50 µM. TNF-α-IN-18has been shown to alleviate sepsis induced by TNF or lipopolysaccharide in mouse models, and provides significant protection against the development and progression of rheumatoid arthritis in murine models.

The Anti-Mouse?TNF-alpha/TNFSF2 Antibody (XT3.11) is a rat-derived IgG1 monoclonal antibody targeting TNF-alpha/TNFSF2. The isotype control for this product is RatIgG1kappa, Isotype Control.

Anti-TNF-alpha Antibody (3L489) is a Rabbit IgG monoclonal antibody targeting Mouse TNF-alpha.

Anti-TNF-alpha Antibody (5Z310) is a Mouse IgG1 monoclonal antibody targeting Human TNF-alpha.

Anti-TNF-alpha Antibody (9S740) is a Rabbit IgG monoclonal antibody targeting Human TNF-alpha.

Human TNF alpha (46-65) peptide.

TNF-α (31-45), human acetate is a peptide of tumor necrosis factor-α.

TNF-alpha-IN-1 (compound 202) is an orally active TNF-alpha inhibitor. This compound possesses anti-inflammatory properties and is applicable in research related to rheumatoid arthritis, psoriasis, and asthma.