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5-br-4-cl-pyrrolo-pyroxypyridine

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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5-Br-4-Cl-Pyrrolo-pyroxypyridine
T2003282914920-46-8
5-Br-4-Cl-Pyrrolo-pyroxypyridine serves as a ligand for target proteins in PROTACs (Ligands for Target Protein for PROTACs). This compound is utilized in the synthesis process.
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CRBN ligand-9
2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione
T936055003-81-1
CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) exhibit inhibition of CRBN.
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TargetMol | Inhibitor Sale
ARCC-4
T143181973403-00-7
ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degrader based on PROTAC, with a DC50 of 5 nM. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1].
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Propargyl-PEG1-acid
T1658355683-37-9
Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].
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7-10 days
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Propargyl-PEG4-5-nitrophenyl carbonate
T166131422540-81-5
Propargyl-PEG4-5-nitrophenyl carbonate is a polyethylene glycol (PEG) derivative designed as a linker for proteolysis targeting chimeras (PROTACs) synthesis [1].
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Propynol Ethoxylate
T166563973-18-0
Propynol Ethoxylate is a PEG-based linker for PROTACs [Proteolysis Targeting Chimeras] that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
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7-10 days
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(S,R,S)-AHPC-PEG4-N3
VH032-PEG4-N3, VHL Ligand-Linker Conjugates 5, E3 ligase Ligand-Linker Conjugates 4
T179211797406-81-5
(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized ligand-linker for E3 ligase-based systems, comprising the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, commonly used in PROTAC technology.
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PROTAC SMARCA2/4-degrader-25
T200106
PROTAC SMARCA2 4-degrader-25 is a PROTAC that targets SMARCA2 4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2 4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.
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Ionizable Lipid 4
T2017511799316-81-6
Ionizable Lipid 4 is an ionizable cationic lipid that forms as a product of the rearrangement of cationic lipid CA-lipid 5 under hydrogen peroxide induction.
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PROTAC ER Degrader-14
T2045542504911-73-1
PROTAC ER Degrader-14 (compound 86) is a PROTAC-type estrogen receptor ERR degrader. It comprises an E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide, a PROTAC linker (black part) N-Boc-piperazine, and a target protein ligand (red part) ER ligand-6. The combination of the E3 ligase and linker forms tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate.
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PROTAC BRD4 Degrader-5
T362422409538-70-9
PROTAC BRD4 Degrader-5 is a PROTAC that efficiently degrades BRD4 in HER2-positive and -negative breast cancer cell lines, and is formed by linking von Hippel-Lindau ligand to BRD4 ligand.
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Thalidomide-NH-C5-NH2 hydrochloride
Pomalidomide 4'-alkylC5-amine
T362622375194-03-7
Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC5 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 4 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
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PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8
T36628
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor with IC50 values of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively, effectively degrading the BRD4 protein in PC3 prostate cancer cells[1].
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A 410099.1, amine-Boc
T390811613552-03-6
A-410099.1, also known as amine-Boc, serves as a functionalized IAP ligand instrumental in the synthesis of PROTACs, including those targeting BTK (specifically PROTACs 4 and 5).
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ARD-2128
T396952222111-87-5
ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) that degrades the androgen receptor (AR), effectively reducing AR protein levels, suppressing AR-regulated gene expression in tumor tissues, and inhibiting tumor growth without evident toxicity. This compound holds promise for prostate cancer research.
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PROTAC IRAK4 degrader-5
PROTAC IRAK4 degrader-5
T399022360530-61-4
PROTAC IRAK4 degrader-5 is a Cereblon-based compound designed to selectively degrade IRAK4.
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A 410099.1, amine-Boc hydrochloride
T399192374122-37-7
A 410099.1, amine-Boc hydrochloride, serves as a functionalized IAP (Inhibitor of Apoptosis Proteins) ligand instrumental in the synthesis of PROTACs (Proteolysis Targeting Chimeras), notably those targeting BTK (Bruton's Tyrosine Kinase), including PROTACs 4 and 5.
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7-10 days
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Nampt-IN-10 TFA
T642732567724-20-1
Nampt-IN-10 TFA (compound 4) is a phosphoribosyltransferase (NAMPT) inhibitor with cellular efficacy against A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), and can be used as a non-antimitotic payload for ADCs.
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8-10 weeks
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Methyl cis-4-Hydroxy-L-proline Hydrochloride
T6522240126-30-5
Methyl cis-4-Hydroxy-L-proline Hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65222 and the CAS number is 40126-30-5.
    7-10 days
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    N-Boc-cis-4-Hydroxy-D-proline
    T65722135042-12-5
    N-Boc-cis-4-Hydroxy-D-proline [Catalog Number: T65722, CAS Number: 135042-12-5] is a valuable organic compound for life sciences research.
      7-10 days
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      Nampt-IN-10 trihydrochloride
      T74562
      Nampt-IN-10 trihydrochloride (Compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor exhibiting cellular potency against A2780 and CORL23 cell lines, with IC50 values of 5 nM and 19 nM, respectively. It holds potential as a novel non-antimitotic payload for antibody-drug conjugate (ADC) [1].
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      KTX-582
      T746642573298-13-0
      KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros. It effectively induces apoptosis in MYD88 MT DLBCL and has demonstrated efficacy in inducing in vivo tumor regressions in a lymphoma model [1] [2] [3].
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      LL-K9-3
      T839362809353-52-2
      LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the CDK9 inhibitor, SNS 032, linked to a hydrophobic tag via a glycol linker. Notably, LL-K9-3 does not affect the degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). Tested in 22RV1 cells, it effectively reduces androgen receptor (AR) and cMyc expression by inducing the selective and synchronous degradation of CDK9 and cyclin T1.
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      Lenalidomide 5'-piperazine-4-methylpiperidine 2HCl
      T868062520105-60-4
      Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride serves as a specialized cerebellar ligand suitable for PROTAC development. It integrates an E3 ligand with a terminal piperidine, facilitating subsequent chemical reactions. This compound enables the creation of a protein degradant featuring a rigid connector [1].
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