A monoclonal antibody is secreted by a single B lymphocyte clone which can only produce a kind of proprietary antibody against an antigen-determining cluster, and has the characteristics of single biological activity and particular specificity of binding with antigen.
The active sites of monoclonal antibody drugs involve a variety of tumor-related signaling pathways and targets. For example, the most common targets are epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor -2 (her-2 /neu, or egfr-2). Besides, there is a group of targets that are getting a lot of attention called “immune checkpoints”.
After the activation of immune cells that regulate the anti-tumor immune response, a variety of highly expressed receptors on the surface of immune cells bind to the highly expressed ligands on the surface of tumor cells to reduce the strength of the immune response, thus down-regulating the intensity of tumor-related immune response. These immunoregulatory sites are known as immune checkpoints. Currently, the most widely studied immune checkpoints are PD-1, PD-L1, and CTLA-4.
Targetmol provides 30 monoclonal antibody drugs, including the above immune checkpoint inhibitors and other types of targeted antibody inhibitors, for scientific research only.
Cat. No. | Product name | CAS No. | Purity | Chemical Structure |
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T36653 | Anti-SARS-80R mAb | 98% |
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Anti-SARS-80R mAb (SARS-80R) is a human IgG1 monoclonal antibody that is derived from CHO cells. Its main function is to selectively bind to the Spike (S1) prote... | ||||
T36654 | Anti-SARS-CoV-2 Spike mAb (CR3022) | 98% |
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Anti-SARS-CoV-2 Spike mAb (CR3022) is a human monoclonal IgG1 antibody derived from CHO cells. It specifically targets the S1 domain of the Spike protein in both... | ||||
T35394 | Sintilimab (anti-PD-1) | 2072873-06-2 | 98% |
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Sintilimab (IBI308) is a humanized IgG4 monoclonal antibody with significant anti-tumor activity that restores endogenous anti-tumor T-cell responses by binding ... | ||||
T9914 | Vedolizumab | 943609-66-3 | 98% |
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Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis. | ||||
T35397 | Sacituzumab (anti-Trop-2) | 1796566-95-4 | 98% |
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The antibody moiety of sacituzumab govitecan selectively binds to TROP2. After internalization and proteolytic cleavage, SN-38 selectively stabilizes topoisomera... | ||||
T11126 | Durvalumab | 1428935-60-7 | 98% |
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Durvalumab is an anti-PD-L1 monoclonal antibody, humanized.Durvalumab completely blocked the binding of PD-L1 to PD-1 and CD80, and the IC50s were 0.1 and 0.04 n... | ||||
T9923 | Nimotuzumab | 828933-51-3 | 98% |
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Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR). | ||||
T36651 | Anti-MERS-2E6 mAb | 98% |
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Anti-MERS-2E6 mAb (MERS-2E6), a human IgG1 neutralizing antibody, is expressed in CHO cells. It effectively competes with the virus Spike protein for binding to ... | ||||
T9904 | Bevacizumab | 216974-75-3 | 98% |
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Ipilimumab anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibito... | ||||
T38951 | Isatuximab | 1461640-62-9 | 98% |
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Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38 , a protein highly expressed on hematological malignant cells, inclu... | ||||
T36655 | Anti-Spike-RBD mAb | 98% |
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Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of spike protein and ACE2 is a potential therapeutic approach f... | ||||
T9922 | Matuzumab | 339186-68-4 | 98% |
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Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR frequently associated with the growth of blood vessels in ... | ||||
T35389 | Sarilumab (anti-IL-6Rα) | 98% |
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T36656 | Anti-Spike-RBD Single Domain mAb | 98% |
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The Anti-Spike-RBD Single Domain mAb is a monoclonal antibody derived from CHO cells in Alpaca. It is composed of VHH-huFc and exhibits a strong affinity for the... | ||||
T12706 | Reslizumab | 241473-69-8 | 98% |
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Reslizumab is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma. | ||||
T39057 | Rozanolixizumab | 1584645-37-3 | 98% |
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Rozanolixizumab (UCB7665) is a humanized monoclonal antibody (IgG4P) that exhibits high affinity for the human neonatal Fc receptor (FcRn). Its application lies ... | ||||
T9931 | Meplazumab | 2413715-21-4 | 98% |
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meplazumab is a humanized anti-CD147 antibody, as add-on therapy in patients with COVID-19 pneumonia. | ||||
T36652 | Anti-MERS-3A1 mAb | 98% |
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Anti-MERS-3A1 mAb (MERS-3A1) is a high-affinity human monoclonal IgG1 antibody derived from CHO cells. It effectively inhibits the interaction between the MERS-C... | ||||
T35396 | Spartalizumab (anti-PD-1) | 98% |
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T9917 | Denosumab | 615258-40-7 | 98% |
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Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand |