linker

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM). It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC.

cIAP1 Ligand-Linker Conjugates 11 is a chemical compound that combines an IAP ligand specifically designed for the E3 ubiquitin ligase with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 11, is useful in the development of SNIPERs[1], allowing for the targeted degradation of proteins.

cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1].

cIAP1 Ligand-Linker Conjugates 4 is a chemical compound that comprises an IAP ligand specifically designed for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 4, has the potential to be utilized in the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 6 hydrochloride combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker, and is utilized for designing SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 14 consist of an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker. These conjugates, known as cIAP1 Ligand-Linker Conjugates 14, are used in the development of SNIPERs[1].

E3 Ligase Ligand-Linker Conjugate 135 is a critical intermediate in the synthesis of the complete PROTAC molecule pan-KRAS degrader 5, comprising a conjugate of E3 ligase ligand and linker.

E3LigaseLigand-linker Conjugate 111 is an E3 ubiquitin ligase ligand-linker conjugate.

E3 Ligase Ligand-linker Conjugate 115, a type of E3 ubiquitin ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates), is utilized in the synthesis of PROTAC SMARCA2 4-degrader-27.

E3 Ligase Ligand-linker Conjugate 117, a conjugate of E3 ubiquitinase ligand and linker (E3 Ligase Ligand-Linker Conjugates), is utilized in the synthesis of PROTAC SMARCA2 4-degrader-29.

E3 Ligase Ligand-linker Conjugate 137 serves as both a linker and an E3 ligase ligand for PROTAC METTL3-14 degrader 1, employed in the study of acute myeloid leukemia.

E3 ligase Ligand-Linker Conjugate 39, a conjugate of an E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. This conjugate can act as a Cereblon ligand to recruit CRBN protein and serve as a crucial intermediate in the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 91, a conjugate of an E3 ligase ligand and linker, consists of (S,R,S)-AHPC and the corresponding linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. This conjugate serves as a key intermediate for synthesizing complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 15, a conjugate of E3 ubiquitin ligase ligand-linker, can be utilized for synthesizing complete PROTACs molecules.

E3 Ligase Ligand-linker Conjugate 141 is a combination of an E3 ubiquitin ligase ligand and a linker, utilized in the synthesis of PROTACER Degrader-12.

E3 Ligase Ligand-linker Conjugate 151 is a conjugate of an E3 ligase ligand and a linker. It is utilized in the synthesis of PROTAC SMARCA2 4 degrader-36.

E3 LigaseLigand-linker Conjugate 161 is an E3 ubiquitin ligase ligand-linker conjugate (E3ligaseligand-linker conjugate) used in the synthesis of Tamoxifen-PEG-Clozapine.

ERRα Ligand-Linker Conjugates 1 refers to a chemical compound that consists of a ligand targeting estrogen-related receptor alpha (ERRα), and a PROTAC linker that facilitates the recruitment of E3 ligases MDM2. It finds utility in the synthesis of a range of PROTACs, including one known as PROTAC ERRalpha Degrader-1. With its capability to induce degradation of ERRα, PROTAC ERRalpha Degrader-1 functions as an ERRα degrader[1].

K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in synthesizing PROTAC K-Ras Degrader-1, a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

cIAP1 Ligand-Linker Conjugates 15 consists of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 15, is suitable for the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1].

cIAP1 Ligand-Linker Conjugates 2 Hydrochloride is a chemical compound that combines an IAP ligand, targeting the E3 ubiquitin ligase, with a PROTAC linker and is utilized in the creation of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 12 is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 12, is valuable for creating SNIPERs[1].