5a

5a is an agonist of 5-HT4R partial. It displayed cognition-enhancing properties in animal models.

5a-Pregnane-3,20-dione is a biologically active 5-alpha-reduced metabolite of plasma progesterone.

KDM5A-IN-1 is an orally available, potent and selective inhibitor of the pan-histidine lysine demethylase 5 KDM5, inhibiting KDM5A, KDM5B, and KDM5C with IC50 values of 45 nM, 56 nM, and 55 nM, respectively.KDM5A-IN-1 inhibits PC9 H3K4Me3, and may be useful in cancer research.

UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.

Abiraterone Metabolite 1, a 5β-reduced derivative of abiraterone, acts by inhibiting CYP17A1, thereby blocking androgen synthesis and extending survival in prostate cancer patients.

5α-Cholestan-3-one (Coprostanone) is an intermediate product in cholesterol metabolism, which is elevated in the case of cerebrotendinous xanthomatosis. Within the cell, It is primarily located in the membrane (predicted from logP).

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, synthesized by androgen-responsive prostate cancer cells under starvation conditions.

W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophi

NDT 9513727 is a potent, selective, and competitive C5aR1 inverse agonist used in the study of inflammatory and immune disorders.

Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall.

3α,21-Dihydroxy-5α-pregnan-20-one (5alpha-THDOC) is a neurosteroid, a gamma-aminobutyric acid (GABAA) modulator, which is used in the study of neurological disorders such as Alzheimer's disease.

5α-Hydroxy-6-keto cholesterol is a β-epoxide metabolite and cholesterol derivative produced in human bronchial epithelial cells (16-HBE) exposed to ozone. It inhibits cholesterol synthesis (IC50=350 nM) and exhibits cytotoxicity.

Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM and serves as a late-stage precursor in cholesterol biosynthesis.

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a bile acid metabolite and T-cell modulator with anti-inflammatory activity, associated with human immune homeostasis.

3β,5α,6β-Trihydroxycholestane is a cholesterol metabolite found mainly in animal fats and can modulate SMO activity.3β,5α,6β-Trihydroxycholestane can be used as a biomarker for schizophrenia.

5α-Cholesta-7,24-dien-3β-ol is a natural sterol and endogenous metabolite in hamsters, suitable for biochemical experiments and drug synthesis research.

Androsterone, a metabolic product of testosterone, can activate Farnesoid X Receptor (FXR).

PAN12314, also known as Compound 5a, is a 5-HT4R partial agonists that displayed cognition-enhancing properties in animal models. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Avacopan (CCX168) is a C5aR antagonist (IC50=0.1 nM) with selective and oral activity. Avacopan blocks the action of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a mouse model of AAV. Avacopan can be used to treat anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis.

5α-Hydroxycostic acid, a naturally occurring sesquiterpene, inhibits choroidal neovascularization in rats through dual signaling pathways mediated by VEGF/VEGFR and Ang2/Tie2 (angiopoietin 2), and exhibits anti-inflammatory and anti-angiogenic effects on human breast cancer cells

Stigmastane-3,6-dione has anti-inflammatory activity. 5 alpha-Stigmastane-3,6-dione shows antifeedant activity against bell weevils.

Foxy-5 Ammonium Salt is a WNT5A agonist, a mimetic peptide of WNT5A, a non-classical member of the Wnt family.Foxy-5 Ammonium Salt triggers cytoplasmic free calcium signaling without affecting β-catenin activation and inhibits migration and invasion of epithelial cancer cells.Foxy-5 Foxy-5 Ammonium Salt effectively reduces the metastatic spread of prostate cancer cells with low WNT5A expression in an in situ mouse model.

PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).

5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase. This compound is primarily employed in research studies to investigate its potential efficacy in treating patterned alopecia. It is commonly used in combination with minoxidil, a well-known treatment for hair loss.