5a

5a is an agonist of 5-HT4R partial. It displayed cognition-enhancing properties in animal models.

5a-Pregnane-3,20-dione is a biologically active 5-alpha-reduced metabolite of plasma progesterone.

KDM5A-IN-1 is an orally available, potent and selective inhibitor of the pan-histidine lysine demethylase 5 KDM5, inhibiting KDM5A, KDM5B, and KDM5C with IC50 values of 45 nM, 56 nM, and 55 nM, respectively.KDM5A-IN-1 inhibits PC9 H3K4Me3, and may be useful in cancer research.

TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).

UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.

Abiraterone Metabolite 1, a 5β-reduced derivative of abiraterone, acts by inhibiting CYP17A1, thereby blocking androgen synthesis and extending survival in prostate cancer patients.

5α-Cholestan-3-one (Coprostanone) is an intermediate product in cholesterol metabolism, which is elevated in the case of cerebrotendinous xanthomatosis. Within the cell, It is primarily located in the membrane (predicted from logP).

PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).

(1R,3S,3aR,5aS,6S,9R,11aS,13aR)-1,6-dihydroxy-3a-(hydroxymethyl)-5a,8,8,11a,13a-pentamethyl-3-(propan-2-yl)-9-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,2H,3H,3aH,4H,5H,5aH,5bH,6H,7H,7aH,8H,9H,10H,11H,11aH,13H,13aH,13bH-cyclopenta[a]chrysen-10-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1R,3aR,5aR,5bR,9S,11aR,13aR)-3a,5a,5b,8,8,11a-hexamethyl-1-(prop-1-en-2-yl)-icosahydro-1H-cyclopenta[a]chrysen-9-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(4E)-2-{5a,7-dihydroxy-6,6,9a,11a-tetramethyl-1H,2H,3H,3aH,4H,5H,5aH,6H,7H,8H,9H,9aH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl}-6-hydroxy-5,6-dimethylhept-4-en-3-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3a-({[(2S,3R,4S,5R,6R)-3,5-dihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}carbonyl)-9-hydroxy-5b,8,8,11a-tetramethyl-1-(prop-1-en-2-yl)-icosahydro-1H-cyclopenta[a]chrysene-5a-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-{3-[(4E)-6-(acetyloxy)-2-hydroxy-6-methyl-3-oxohept-4-en-2-yl]-6-(carboxymethyl)-2-hydroxy-3a,5a,9b-trimethyl-5-oxo-1H,2H,3H,3aH,4H,5H,5aH,6H,9H,9aH,9bH-cyclopenta[a]naphthalen-7-yl}-2-methylpropanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, synthesized by androgen-responsive prostate cancer cells under starvation conditions.

W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophi

NDT 9513727 is a potent, selective, and competitive C5aR1 inverse agonist used in the study of inflammatory and immune disorders.

Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall.

3α,21-Dihydroxy-5α-pregnan-20-one (5alpha-THDOC) is a neurosteroid, a gamma-aminobutyric acid (GABAA) modulator, which is used in the study of neurological disorders such as Alzheimer's disease.

5α-Hydroxy-6-keto cholesterol is a β-epoxide metabolite and cholesterol derivative produced in human bronchial epithelial cells (16-HBE) exposed to ozone. It inhibits cholesterol synthesis (IC50=350 nM) and exhibits cytotoxicity.

Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM and serves as a late-stage precursor in cholesterol biosynthesis.

Cholesterol-5α,6α-epoxide (Epoxycholesterol) is the metabolite of cholesterol produced by oxidation. Cholesterol-5α,6α-epoxide induces triacylglycerol biosynthesis by binding to LXRβ following tamoxifen and PBPE application.

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a bile acid metabolite and T-cell modulator with anti-inflammatory activity, associated with human immune homeostasis.

3β,5α,6β-Trihydroxycholestane is a cholesterol metabolite found mainly in animal fats and can modulate SMO activity.3β,5α,6β-Trihydroxycholestane can be used as a biomarker for schizophrenia.

5α-Cholesta-7,24-dien-3β-ol is a natural sterol and endogenous metabolite in hamsters, suitable for biochemical experiments and drug synthesis research.