d4

Leukotriene D4 (LTD4) is a potent pro-inflammatory mediator formed from arachidonic acid, a bronchoconstrictor, and induces osteoclast senescence.Leukotriene D4 induces transcriptional activity of potentially oncogenic genes and can be used in the study of asthma.

Amoxicillin-D4 is a deuterium-labeled Amoxicillin. Amoxicillin (T1005) is an antibiotic with broad-spectrum antimicrobial activity.

Aprocitentan-D4 is a deuterium-labeled Aprocitentan. Aprocitentan (T7817) is a major and pharmacologically active metabolite of Macitentan. Aprocitentan (T7817) is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5).

Bexarotene-D4 is a deuterium-labeled Bexarotene (T6410) (LGD1069). Bexarotene (T6410) is a selective RXR agonist used in the treatment of cutaneous T-cell lymphoma.

Candesartan-D4 is the deuterated form of Candesartan (TMSM-3481). It is an orally active Angiotensin II AT1 receptor blocker and PPAR-γ agonist with long-lasting antihypertensive effects, used as an internal standard in PK studies.

Cetirizine-D4 is a deuterium-labeled Cetirizine. Cetirizine (T0089L) is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.

Dabigatran-D4 hydrochloride is deuterium-labeled dabigatran, which is a reversible and selective direct thrombin inhibitor (DTI) with a Ki value of 4.5 nM.

Delamanid-D4 is deuterium-labeled Delamanid. Delamanid (T4202) is a newer mycobacterial cell wall synthesis inhibitor that inhibits the synthesis of mucus acid.

Dofetilide-D4 (UK 68789 D4), a deuterium-labeled version of Dofetilide, is categorized as a Class III antiarrhythmic medication.

Enclomiphene-D4 hydrochloride is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property. Enclomiphene D4 hydrochloride ( (E)-Clomiphene D4 hydrochloride; trans-Clomiphene D4 hydrochloride; Enclomifene D4 hydrochloride) is a deuterium labeled Enclomiphene hydrochloride (T62572).

Etoricoxib-D4 is a deuterated form of Etoricoxib. Etoricoxib (T1574) is a synthetic non-steroidal anti-inflammatory compound, an orally available and selective COX-2 inhibitor with antipyretic, analgesic, and potential anticancer properties.

Etravirine (T2551) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. Etravirine-D4 is the deuterium labeled Etravirine.

Haloperidol-D4 is deuterium-labeled Haloperidol (TMSM-3424).

Hydroxyzine-D4 is a deuterium-labeled variation of Hydroxyzine (T20884), a chemical compound known for its anticholinergic, anxiolytic, and analgesic properties. It is classified as a heterocyclic histamine H1-receptor antagonist.

Imatinib-D4 is a deuterium-labeled Imatinib. Imatinib (T6230) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.

Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin (T0458) is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.

Irbesartan-D4 is an angiotensin receptor blocker that is used in the study of cardiovascular disease.

Lansoprazole Sulfide-D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide (T21128) is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole.

Losartan (D4 Carboxylic Acid) is the deuterium labeled Losartan (TMSM-3475), which is an angiotensin II receptor antagonist.

Losartan-D4 is a deuterated isotope of Losartan (T0215L) for isotopic tracing. Losartan (T0215L) is an angiotensin II receptor antagonist (IC50=20 nM).

Macitentan-D4 is a deuterated substitute for Macitentan (T2561) and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor).Macitentan-D4 is less toxic than Macitentan, has a longer half-life, and can be used to study endothelin receptor-mediated diseases.

Nitazoxanide-D4 is the deuterium labeled Nitazoxanide (T1546).

Olmesartan-D4 is the deuterium labeled Olmesartan. Olmesartan (T5964) is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure.

Ospemifene-D4 is a deuterium labeled Ospemifene. Ospemifene (T6620) is a selective and orally active modulator of estrogen receptor.