transferase

OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.

Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic effects.

Gamma-Glutamyl Transferase-IN-2 (compound 4dq), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting glutamyltransferase, inducing reactive oxygen species accumulation, compromising cell membranes, and disrupting histone acetylation processes [1].

Gamma-Glutamyl Transferase-IN-1 (compound 4de), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting glutamyltransferase, inducing reactive oxygen species accumulation, disrupting cell membranes, and dysregulating histone acetylation [1].

Glucosaminyl (N-acetyl) Transferase 1 (EC:2.4.1.102, GCNT1) is crucial for the formation of the Gal beta 1-3(GlcNAc beta 1-6)GalNAc structure and core 2 O-glycan branching and plays a significant role in cancer.

Glucosaminyl (N-acetyl) Transferase 2 (EC:2.4.1.150, GCNT2, GCNT5, NACGT1, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, N-acetylglucosaminyltransferase, IGNT) is responsible for the formation of the I antigen in blood type and also plays a significant role in cancer.

α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity. Vapendavir diphosphate inhibits EV71 replication.

Glycosyltransferase-IN-1 is a glycosyltransferase inhibitor with bacteriostatic activity, inhibiting MSSA, MRSA, Bacillus subtilis, and Enterobacteriaceae.

Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 µM. 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 μM.

Alpha-1,3-N-Acetylgalactosaminyltransferase (Pm1138) (EC 2.4.1.40(Pm1138)), also known as the ABO system transferase, exhibits glycosyl transferase activity [1].

Phosphate acetyltransferase, a transferase enzyme utilized in biochemical research, catalyzes the reversible acetylation of CoA from acetyl-P, yielding acetyl-CoA and inorganic phosphate. This process is integral to acetate assimilation dissimilation reactions [1].

Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1.

Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.

Purinephosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of Plasmodium falciparum (Pf), Plasmodium vivax (Pv), and Trypanosoma brucei (Tbr) 6-oxopurine phosphate ribosyltransferase (PRT), with Ki values of 50 nM, 20 nM, and 2 nM, respectively.

Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of Plasmodium falciparum (Pf), Plasmodium vivax (Pv), and Trypanosoma brucei (Tbr) 6-oxopurine phosphoribosyltransferase (PRT) with Ki values of 30, 20, and 2 nM, respectively.

Catechol O-methyltransferase (COMT) is a key enzyme in the regulation of melatonin synthesis, which is involved in the regulation of plant growth and development, and can be inhibited by structurally specific heparin oligosaccharides.

GlcNAc 1-P uridyltransferase (CjGlmU), a sugar nucleotidyltransferase (SNT), employs UTP and GlcNAc-1-P to synthesize UDP-GlcNAc, with potential implications in antimicrobial agent research [1].

Beta-1, 3-N-Acetylhexaminyltransferase (LgtA), a glycosyltransferase, plays a critical role in biochemical studies by catalyzing the transfer of N-acetylglucosamine from UDP-GlcNAc to substrates including N-acetyllactosamine and lactose [1].

Beta-1,4-Galactosyltransferase (LgtB) (B4GALT1(LgtB)), a key enzyme in biochemical research, catalyzes the transfer of UDP-galactose to N-acetylglucosamine, resulting in the synthesis of galactose beta-1,4-N-acetylglucosamine [1].

Alpha-1,4-Galactosyltransferase (LgtC) (A4GALT), a glycosphingolipid-specific glycosyltransferase, catalyzes the transfer of a galactose molecule to the alpha-1,4 position on lactosylceramide, resulting in the formation of globotriaosylceramide. This enzyme plays a crucial role in the synthesis of P1 blood group antigens [1] [2].

Beta-1,3-Galactosyltransferase (CgtB) (GM1-synthase), an enzyme critical for the production of sialylated lipooligosaccharide (LOS SIAL), plays a key role in biochemical research. This enzyme facilitates the incorporation of a galactose molecule essential for generating a GM1-like LOS SIAL structure.

Alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the synthesis of the α-gal epitope by transferring a galactose (Gal) molecule in an α1-3 linkage from a uridyl-diphosphate (UDP) donor to the N-acetyllactosamine (Galβ1,4GlcNAc-R) on glycoproteins. This enzyme is essential for the production of the α-galactose (α-Gal) epitope, a biomolecule prevalent in most mammalian species [1].

Alpha-1,3-Galactosyltransferase (GTB) (alpha 1,3GT) is responsible for catalyzing the synthesis of the α-galactose (α-Gal) epitope, known as a xenoantigen. This enzyme facilitates the transfer of galactose from UDP-Gal to either type 1 or type 2 αFuc1→2βGal-R (H)-terminating acceptors [1].

Alpha-2,8-Sialyltransferase (CstII) (ST8Sia VI), belonging to the alpha2,8-sialyltransferase (ST8Sia) family, primarily catalyzes the elongation of the α2,8-linked oligo polysialic acid chain on the sialic acid (Sia) residue. It is frequently utilized in biochemical research.