17-odya

Squalane is a lipid found in some fish oils (especially shark liver oil) and some vegetable oils. It has anticancer and antioxidant properties and is used as a skin moisturizer and emollient.

(+)-JQ-1 (JQ1) is a specific, reversible BET bromine domain inhibitor that targets BRD4 (1 2) with IC50 values of 77 33 nM. (+)-JQ-1 induces cell autophagy and inhibits cell proliferation.

Propargyl-PEG17-methane (MPEG16-Propyne) is a PEG-based PROTAC linker. Propargyl-PEG17-methane can be used in the synthesis of PROTACs.

MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.

HO-PEG17-OH is a PEG-based linker for PROTACs, joining two essential ligands that are crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) is a PEG-based compound used as a linker in the synthesis of PROTACs[1].

SNIPER(BRD)-1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+)-JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway and effectively degrades cIAP1, cIAP2, and XIAP with IC50 values of 6.8 nM, 17 nM, and 49nM, respectively[1].

Amino-PEG6-amido-C16-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs [1].

Amino-PEG6-amido-C16-COOH, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Amino-PEG9-amido-C16-Boc is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Azide-PEG6-amido-C16-Boc is an alkyl ether-based PROTAC linker used in PROTAC synthesis[1].

Azide-PEG9-amido-C16-Boc is an alkyl ether-based PROTAC linker used in PROTAC synthesis [1].

Bis-PEG17-acid, a PEG-based linker for PROTACs, joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG17-NHS ester is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Bis-propargyl-O-PEG17 is a PEG-based linker for PROTACs that connects two essential ligands, crucial for forming PROTAC molecules, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].

m-PEG17-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

m-PEG17-Hydrazide is a PEG-based linker for PROTACs, essential for joining two ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

m-PEG17-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, including the notable ARD-266. ARD-266 is an exceptionally effective androgen receptor (AR) PROTAC degrader[1].

PROTAC SMARCA2 degrader-17 (compound I-290) is a targeted PROTAC degrader for SMARCA2. It exhibits a DC50 of less than 100 nM and achieves a maximum degradation efficiency (Dmax%) of over 90% in A549 cells after 24 hours of treatment.

YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)

CRBN ligand-17 is a CRBN-type E3 ubiquitin ligase ligand, suitable for the preparation of PROTAC.

PEG17 is a PEG linker, which may be useful in the development of antibody-drug conjugates.