t 10

Dextran T10 (MW 10,000) is a polymer of dehydrated glucose with an average molecular weight of 10,000. It exhibits excellent biodegradability and biocompatibility, making it suitable for applications in food, pharmaceuticals, cosmetics, and research fields.

RORγt Inverse agonist 10 is a highly potent, orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectively inhibits RORγt activity, a key transcription factor regulating genes linked to psoriasis pathogenesis, including [IL-17A], [IL-22], and [IL-23R].

Tripeptide-10 Citrulline (T10-C) is a bioactive peptide recognized for its anti-aging properties and has been documented as an ingredient in cosmetics [1].

Ms-PEG10-t-butyl ester is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Benzyl-PEG10-t-butyl ester is a PROTAC linker belonging to the PEG category, used in the synthesis of PROTAC molecules.

Bromo-PEG10-t-butyl ester is a PROTAC linker belonging to the PEG class, and it can be used in the synthesis of PROTAC molecules.

t-Boc-amido-PEG10-acid is a PROTAC linker classified under the PEG category and is utilized in the synthesis of PROTAC molecules.

t-Boc-N-amido-PEG10-Br is a PEG-based PROTAC linker used in the synthesis of PROTAC molecules.

Acid-PEG10-t-butyl ester is a PROTAC linker within the PEG category, used for synthesizing PROTAC molecules.

isomer-GAT 107 ((-)GAT 107) is an inactive isomer of (+)GAT 107.

ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.

N-[(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea is a potent TRPV1 antagonist, blocking activation of TRPV1 by capsaicin with the IC50 of 123 nM.

5-[(1S,2S)-2-[(Cyclopropylmethyl)amino]cyclopropyl]-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamide hydrochloride is a cyclopropanoid enzyme compound that acts as a lysine-specific demethylase-1 inhibitor for schizophrenia, developmental disorders, and neurodegenerative diseases.

Antidepressant agent 10 ,with CAS No. 87691-87-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Antidepressant agent 10 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Antifungalagent 109 (compound F) is a spirorings [thiazolidinone] compound with antifungal properties, exhibiting inhibition zones of 10-17 mm.

CXCR4 antagonist 10 is a small-molecule antagonist of the chemokine receptor CXCR4 that inhibits related signaling pathways and cell migration by blocking the binding of CXCR4 to its ligand, CXCL12 (SDF-1). In vitro studies have shown that CXCR4 antagonist 10 can interfere with tumor cell metastasis and immune cell chemotaxis, demonstrating potential value in antitumor and anti-inflammatory research.

APJ receptor agonist 10 (Compound I choline salt) modulates the activity of the APJ receptor, making it useful for pulmonary hypertension research. Compared to its free form, this compound exhibits improved bioavailability.

FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.

AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.

Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.

Anti-inflammatory agent 100 (Compound (+)-4S-23) is an anti-inflammatory compound. It inhibits the MAPK and NF-κB signaling pathways by preventing the phosphorylation of IκB-α and blocking the nuclear translocation of phosphorylated p65. Anti-inflammatory agent 100 also reduces the production of NO (IC50: 0.5 μM) and the secretion of TNF-α, IL-6, and IL-1β.

Neuroprotective agent 10 (Compound 11c) is a brain-penetrant neuroprotective compound. It effectively scavenges ABTS radicals (IC50 for scavenging: 9.20 μM), DPPH radicals (IC50 for scavenging: 7.09 μM), and superoxide anion radicals (inhibition rate: 48.4%). Additionally, it mitigates oxidative damage induced by H2O2 and neuroinflammation induced by lipopolysaccharides, demonstrating antiepileptic properties. Neuroprotective agent 10 shows promise for research in epilepsy and neuroprotection.

TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.