t 10

Dextran T10 (MW 10,000) is a polymer of dehydrated glucose with an average molecular weight of 10,000. It exhibits excellent biodegradability and biocompatibility, making it suitable for applications in food, pharmaceuticals, cosmetics, and research fields.

(T-4)-Copper(1+), bis[2,9-bis(4-methoxyphenyl)-1,10-phenanthroline-κN1,κN10]-, chloride is a reagent used in biochemical reactions.

(S)-BMT 108908 FA is the enantiomer of BMT 108908. BMT-108908 FA is a selective negative allosteric modulator of the NMDA receptor GluN2B subunit.

NT1-O14B is a novel class of neurotransmitter tryptophan lipids (NT-lipidoids).NT1-O14B can be combined with small molecule drugs (e.g., AmB) and biomolecules (e.g., Tau-ASO) and gene editing proteins (GFP-Cre) to form new neurotransmitter-derived lipid nanoparticles (NT-LNPs) that have blood-brain-barrier (BBB) permeability. Enhanced lipid hydrophobicity and membrane fusion capabilities are commonly used for delivery of nucleic acids such as mRNA, siRNA and DNA.

Dextran T100 (MW 100,000) is a dehydrated glucose polymer with an average molecular weight of 100,000. This compound exhibits excellent biodegradability and biocompatibility, making it suitable for applications in the food, pharmaceutical, cosmetics, and research sectors.

Carbohydrate Sulfotransferase 10 (EC:2.8.2.-) catalyzes the transfer of sulfate groups to the 3-position of terminal glucuronic acid residues in oligosaccharides that are attached to proteins and lipids.

Tetrabutylammonium bromide is an organic ammonium salt compound frequently used in catalytic reactions and purification processes. It demonstrates notable catalytic effects in certain organic synthesis reactions and can serve as a surfactant, stabilizer, and antibacterial agent. Additionally, in some laboratory studies, it is utilized as an ion exchanger and solvent extractor.

(R,R)-VRT-534 is the enantiomer of VRT-534. EBET-1055 is a bromodomain and extra-terminal (BET) PROTAC degrader. It effectively inhibits the growth of pancreatic ductal adenocarcinoma (PDAC). Additionally, EBET-1055 modulates cancer-associated fibroblast (CAF) activity, increasing the activity of all reporter genes in organoid co-cultures.

Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lopez, J.A.V., Nogawa, T., Futamura, Y., et al.Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647J. Antibiot. (Tokyo)72(12)991-995(2019) 2.Ishida, S., Arai, M., Niikawa, H., et al.Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium speciesBiol. Pharm. Bull.34(6)917-920(2011) 3.Kalinovskaya, N.I., Romaneko, L.A., Irisawa, T., et al.Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activityMicrobiol. Res.166(8)654-661(2011) 4.Matsubara, K., Sakuda, S., Tanaka, M., et al.Morphological changes in insect BM-N4 cells induced by nocardamineBiosci. Biotechnol. Biochem.62(10)2049-2051(1998)

L-Asparaginase (L-ASNase) (L-ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment.Asparaginase is an enzyme that is used as a medication. As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and non-Hodgkin's lymphoma. It is given by injection into a vein, muscle, or under the skin.