Search Result

Search Results for " competitive "

Targets

1138

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8580	Bupranolol		Adrenergic Receptor
	Bupranolol is an antagonist of β2-adrenergic receptor and has been used for angina pectoris, hypertension, glaucoma, cardiac arrhythmia and as an antithrombotic.		Adrenergic Receptor
T10140	4-Diethylaminobenzaldehyde		Dehydrogenase
	4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71μM).		Dehydrogenase
T3624	A-366	A 366,A366	Epigenetic Reader Domain , Histone Methyltransferase
	A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met...		Epigenetic Reader Domain , Histone Methyltransferase
T8796	CAN508		CDK
	CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50...		CDK
T8535	GAK inhibitor 49		Serine/threonin kinase
	GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ).		Serine/threonin kinase
T4340	SPI-112		Phosphatase
	SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.		Phosphatase
T11464	GRL0617		SARS-CoV , DUB
	GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).		SARS-CoV , DUB
T8987	Epiblastin A		Casein Kinase
	Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs).		Casein Kinase
T4182	Lavendustin B		Tyrosinase , transporter , HIV Protease
	Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).		Tyrosinase , transporter , HIV Protease
T8459	DNQX disodium salt	DNQX Disodium	NMDAR , iGluR
	DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor		NMDAR , iGluR
T21302	UNC569	UNC 569	TAM Receptor
	UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amoun...		TAM Receptor
T12642L	Simurosertib	TAK-931	CDK
	Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).		CDK
T8230	PNU112455A hydrochloride	PNU 112455A	CDK
	PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.		CDK
T5414	Glumetinib	SCC244	c-Met/HGFR
	Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).		c-Met/HGFR
T7304	DNQX	FG 9041	GluR , iGluR
	DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)		GluR , iGluR
T4348	Syk Inhibitor II		5-HT Receptor , Syk
	Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).		5-HT Receptor , Syk
T28804	Slingshot inhibitor D3	JHN76359	Others
	Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.		Others
T13018	SU3327	halicin	JNK
	SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).		JNK
T14943	CGP60474		VEGFR , CDK , PKC
	CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.		VEGFR , CDK , PKC
T3109	SP600125	1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone	Apoptosis , Ferroptosis , Trk receptor , JNK , Aurora Kinase , Autophagy
	SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive properties. SP600125 inhibits autophagy and induces apoptosis.
T1631	Sulbactam	CP45899	Antibacterial , Antibiotic
	Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabol...		Antibacterial , Antibiotic
T7673	ATH686	ATH 686	Apoptosis , FLT
	ATH686 is an potent and selective Inhibitor of FLT3.		Apoptosis , FLT
T38862	Nandrolone acetate	19-Nortestosterone 17β-acetate	Others
	Nandrolone acetate (19-Nortestosterone 17β-acetate) is a competitive inhibitor of isomerase with the Ki of 7 μM for Δ5-3-ketosteroid isomerase of Pseudomonas testosreroni.		Others
T7194	CM-272		Apoptosis , DNA Methyltransferase , Histone Methyltransferase
	CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T6685	Sulbactam sodium	CP-45899-2	Antibacterial , Antibiotic
	Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor.		Antibacterial , Antibiotic
T5125	LY3200882		TGF-beta/Smad
	LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).		TGF-beta/Smad
T1817	GNF-2	GNF2	SARS-CoV , Bcr-Abl
	GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.		SARS-CoV , Bcr-Abl
T7322	Theliatinib		EGFR
	Theliatinib, a potent and highly selective EGFR inhibitor, with anti-tumor activity. Ki of 0.05 nM for wild type EGFR, and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant, respectively.		EGFR
T1977	Dorsomorphin	Compound C,BML-275	AMPK , Autophagy , TGF-beta/Smad
	Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor ...		AMPK , Autophagy , TGF-beta/Smad
T3186	NU2058	O6-(Cyclohexylmethyl)guanine,O(6)-Cyclohexylmethylguanine	Topoisomerase , CDK
	NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.		Topoisomerase , CDK
T23524	W-84 dibromide	HDMPPA	AChR
	W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.		AChR
T12477	Uzansertib phosphate	INCB053914 phosphate	Pim
	Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively).		Pim
T8976	PD-089828		EGFR , FGFR , PDGFR , Src
	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ...		EGFR , FGFR , PDGFR , Src
TQ0138	K145 hydrochloride		Apoptosis , S1P Receptor
	K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.		Apoptosis , S1P Receptor
T6626	PF-3758309	PF-309,PF-03758309,PF 3758309	Apoptosis , PAK
	PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition.		Apoptosis , PAK
T6223	U0126-EtOH	U0126 Ethanol,U0126	Mitophagy , Influenza Virus , MEK , Autophagy
	U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).		Mitophagy , Influenza Virus , MEK , Autophagy
T8376	PKCβ inhibitor 1	KUN79359	Apoptosis , PKC
	PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively).		Apoptosis , PKC
T15781	LP-935509		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
	LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-...		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
T24111	GSK3i XIII	GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII	GSK-3
	GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.		GSK-3
T6019	Volasertib	BI 6727	Apoptosis , PLK
	Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).		Apoptosis , PLK
T3096	Canrenoate potassium	Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone	Glucocorticoid Receptor
	Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity.		Glucocorticoid Receptor
T8388	Vonoprazan	TAK-438 (free base)	Proton pump
	Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis		Proton pump
T6893	MK-886	MK886,L 663536	Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
	MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.		Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
T9040	Aurora kinase inhibitor-2	IUN-70219,Aurora Kinase Inhibitor II	Aurora Kinase
	Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).		Aurora Kinase
T2518	ARRY-380 (analog )	HER2-Inhibitor-1,ARRY380,ARRY-380 analog	EGFR , HER
	ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.		EGFR , HER
T22517	5,7-Dichlorokynurenic acid	5,7-dichlorokynurenic acid sodium,5,7-DCKA	NMDAR
	5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) is an NMDA receptor antagonist.		NMDAR
T4230	PF-3758309 hydrochloride	PF-03758309 hydrochloride	Apoptosis , PAK
	PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...		Apoptosis , PAK
T8416	Capmatinib xHCl	INCB28060,Capmatinib hydrochloride(free base),INC280	c-Met/HGFR
	Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activit...		c-Met/HGFR
T21254	Vonoprazan Fumarate	TAK-438,TAK 438,Vonoprazan Fumurate,TAK438	Proton pump
	Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19...		Proton pump
T6085	PF-543	Sphingosine Kinase 1 Inhibitor II,PF 543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor

Compounds

Bupranolol

T8580

Synonym:

Target: Adrenergic Receptor

4-Diethylaminobenzaldehyde

T10140

Synonym:

Target: Dehydrogenase

A-366

T3624

Synonym: A 366,A366

Target: Epigenetic Reader Domain, Histone Methyltransferase

Target: Serine/threonin kinase

Target: SARS-CoV, DUB

Epiblastin A

T8987

Synonym:

Target: Casein Kinase

lavendustin B

T4182

Synonym:

Target: Tyrosinase, transporter, HIV Protease

DNQX disodium salt

T8459

Synonym: DNQX Disodium

PNU112455A hydrochloride

Target: 5-HT Receptor, Syk

Slingshot inhibitor D3

Target: VEGFR, CDK, PKC

SP600125

T3109

Synonym: 1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone

Target: Apoptosis, Ferroptosis, Trk receptor, JNK, Aurora Kinase, Autophagy

Sulbactam

T1631

Synonym: CP45899

Target: Antibacterial, Antibiotic

ATH686

T7673

Synonym: ATH 686

Target: Apoptosis, FLT

Nandrolone acetate

T38862

Synonym: 19-Nortestosterone 17β-acetate

Target: Apoptosis, DNA Methyltransferase, Histone Methyltransferase

Sulbactam sodium

T6685

Synonym: CP-45899-2

Target: Antibacterial, Antibiotic

LY3200882

T5125

Synonym:

Target: TGF-beta/Smad

GNF-2

T1817

Synonym: GNF2

Target: SARS-CoV, Bcr-Abl

Synonym: Compound C,BML-275

Target: AMPK, Autophagy, TGF-beta/Smad

NU2058

T3186

Synonym: O6-(Cyclohexylmethyl)guanine,O(6)-Cyclohexylmethylguanine

Target: Topoisomerase, CDK

Synonym: INCB053914 phosphate

Target: EGFR, FGFR, PDGFR, Src

K145 hydrochloride

TQ0138

Synonym:

Target: Apoptosis, S1P Receptor

PF-3758309

T6626

Synonym: PF-309,PF-03758309,PF 3758309

Target: Apoptosis, PAK

U0126-EtOH

T6223

Synonym: U0126 Ethanol,U0126

Target: Mitophagy, Influenza Virus, MEK, Autophagy

PKCβ inhibitor 1

T8376

Synonym: KUN79359

Target: Apoptosis, PKC

LP-935509

T15781

Synonym:

Target: Serine/threonin kinase, AAK1 (AP2 associated kinase 1)

GSK3i XIII

T24111

Synonym: GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII

Target: Apoptosis, PLK

Canrenoate potassium

T3096

Synonym: Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone

Target: Glucocorticoid Receptor

Vonoprazan

T8388

Synonym: TAK-438 (free base)

Target: Proton pump

MK-886

T6893

Synonym: MK886,L 663536

Target: Apoptosis, Leukotriene Receptor, COX, PPAR, FLAP

Aurora kinase inhibitor-2

T9040

Synonym: IUN-70219,Aurora Kinase Inhibitor II

Target: Aurora Kinase

ARRY-380 (analog )

T2518

Synonym: HER2-Inhibitor-1,ARRY380,ARRY-380 analog

Target: EGFR, HER

5,7-Dichlorokynurenic acid

T22517

Synonym: 5,7-dichlorokynurenic acid sodium,5,7-DCKA

Target: NMDAR

PF-3758309 hydrochloride

T4230

Synonym: PF-03758309 hydrochloride

Target: Apoptosis, PAK

Capmatinib xHCl

T8416

Synonym: INCB28060,Capmatinib hydrochloride(free base),INC280

Target: c-Met/HGFR

Vonoprazan Fumarate

T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438

Target: Proton pump

PF-543

T6085

Synonym: Sphingosine Kinase 1 Inhibitor II,PF 543

Target: Apoptosis, S1P Receptor, Autophagy, LPL Receptor

Cat No.	Product Name	Synonyms	Targets
TN1120	Osthenol		MAO , Monoamine Oxidase
	Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promoting activity, it also has antifungal and antibacterial activ...		MAO , Monoamine Oxidase
T2850	Bicuculline	(+)-Bicuculline,d-Bicuculline	GABA Receptor
	Bicuculline ((+)-Bicuculline) is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungos...		GABA Receptor
TN2004	Obtusin		MAO , Monoamine Oxidase
	Obtusin is a natural product.		MAO , Monoamine Oxidase
TN2019	Orobol	3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon	BCL , Caspase , PI3K
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibit...		BCL , Caspase , PI3K
T0465	Ellagic acid	Gallogen,Elagostasine	Hedgehog/Smoothened , Casein Kinase , Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , PKA , Syk , PKC , Carbonic Anhydrase
	Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used...
T3419	Chelerythrine chloride		Apoptosis , BCL , PKC , Autophagy
	Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.		Apoptosis , BCL , PKC , Autophagy
TN4442	Linderene acetate		Prolyl Endopeptidase (PREP)
	Linderene acetate is a competitive inhibitor against Prolyl endopeptidase.		Prolyl Endopeptidase (PREP)
T11054	DL-Norvaline	2-Aminopentanoic acid	Arginase , Endogenous Metabolite
	DL-Norvaline (2-Aminopentanoic acid) is a non-competitive inhibitor of arginase.		Arginase , Endogenous Metabolite
T10943	D-(-)-Lactic acid	(R)-2-Hydroxypropionic acid	Others , Endogenous Metabolite
	D-(-)-Lactic acid is a normal intermediate in sugar fermentation (oxidation, metabolism). It is identified as a competitive inhibitor of ProDH (proline dehydrogenase) in plants.		Others , Endogenous Metabolite
T1680	Tolazoline hydrochloride	Imidaline hydrochloride,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride)	Adrenergic Receptor
	Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn.		Adrenergic Receptor
T3379	Decanoic Acid	Decoic acid,CAPRIC ACID,Caprynic acid	GluR , iGluR
	Decanoic Acid (Caprynic acid) acts as a non-competitive AMPA receptor antagonist.		GluR , iGluR
T20880	Mesaconic acid	Methylfumaric acid,Mesaconate,Kyselina mesakonova	Others
	Mesaconic acid (Methylfumaric acid) is used as a fire retardant, as recent studies revealed this acid is a competitive inhibitor of fumarate reduction.		Others
TJS0851	Plantagoside		Others
	Plantagoside is a specific non-competitive inhibitor for jack bean alpha-mannosidase (IC50: 5 μM). It also is a potent inhibitor of the Maillard reaction.		Others
T5648	Purpurin	1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin	MAO , Antibacterial , Antibiotic , Antifungal
	Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities.		MAO , Antibacterial , Antibiotic , Antifungal
T1681	Aminophylline	Phyllocontin	PDE , Adenosine Receptor
	Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.		PDE , Adenosine Receptor
TN3748	D-Asparagine	H-D-Asn-OH	Others , Endogenous Metabolite
	D-Asparagine (H-D-Asn-OH) is a source of nitrogen for yeast strains. D-Asparagine is a competitive inhibitor of L-Asparagine hydrolysis (Ki = 0.24 mM).		Others , Endogenous Metabolite
T6430	Calcifediol	U 32070E,25-hydroxy Vitamin D3,RO 8-8892	Endogenous Metabolite
	Calcifediol (U 32070E)(Ki of 3.9 μM), a major circulating metabolite of vitamin D3, works as a competitive inhibitor. It (ED50=2 nM)also inhibits PTH secretion and mRNA.		Endogenous Metabolite
T6856	Halofuginone	Tempostatin,empostatin,RU-19110	Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T8319	Butyl isobutyl phthalate	ButylIsobutylPhthalate	Glucosidase
	Butyl isobutyl phthalate (ButylIsobutylPhthalate) is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect		Glucosidase
T21615	Guanidinoethyl sulfonate	Taurocyamine	Chloride channel
	Guanidinoethyl sulfonate (Taurocyamine) is a competitive glycine receptor antagonist.		Chloride channel
T3401	Ginsenoside F1	20(S)-Ginsenoside F1	P450 , Endogenous Metabolite
	Ginsenoside F1 (20(S)-Ginsenoside F1) is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of the activity of CYP2D6.		P450 , Endogenous Metabolite
T7730	Aminopterin	APGA,4-Aminofolic acid	Antifolate
	Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase		Antifolate
T8044	Ajmalicine	Lamuran,Delta-Yohimbine,Raubasine,Ajmalicin	Adrenergic Receptor
	Ajmalicine (Raubasine) (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine a...		Adrenergic Receptor
T25192	Butyrolactone I	Olomoucin	CDK
	Butyrolactone I (Olomoucin) is an ATP-competitive inhibitor of CDK and cdc2 kinase family. Butyrolactone I shows antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines.		CDK
T6975	Sarcosine	Sarcosinic acid,Methylaminoacetic acid,Sarcosin,Methylglycine,N-Methylaminoacetic acid,N-methylglycine	Others , GlyT , Endogenous Metabolite
	Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.		Others , GlyT , Endogenous Metabolite
TN2030	P-Hydroxyphenethyl trans-ferulate		5-HT Receptor
	P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone reductase specific activity in Hepa 1c1c7 cells at a level...		5-HT Receptor
TN1266	3-O-Methylquercetin		IL Receptor , cAMP , PDE
	3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentr...		IL Receptor , cAMP , PDE
T6680	Staurosporine	Antibiotic AM-2282,AM-2282,CGP 41251	Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal
	Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces...
TN1343	8-Geranyloxypsoralen		Anti-infection , P450 , BACE
	8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal act...		Anti-infection , P450 , BACE
T11590	(-)-Hydroxycitric acid	Garcinia acid	ATP Citrate Lyase
	(-)-Hydroxycitric acid (Garcinia acid) (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses fatty aci...		ATP Citrate Lyase
TN4660	Niranthin		Anti-infection , HBV , PAFR , Topoisomerase
	Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. N...		Anti-infection , HBV , PAFR , Topoisomerase
T6564	Leupeptin Hemisulfate		Serine Protease , Cysteine Protease
	Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and bloc...		Serine Protease , Cysteine Protease
T5291	Malonic acid	Carboxyacetic Acid,1,3-Propanedioic Acid,Propanedioic Acid	Others
	Malonic acid (propanedioic acid) is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associa...		Others
T0809	Dicoumarol	Dicumarol	Dehydrogenase , NADPH , PDK
	Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t...		Dehydrogenase , NADPH , PDK
T4973	Paraxanthine	1,7-DIMETHYLXANTHINE	Endogenous Metabolite
	Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc...		Endogenous Metabolite
T3S1967	(S)-Indoximod	N-ME-Tryptophan,Abrine,L-Abrine	Others , Indoleamine 2,3-Dioxygenase (IDO)
	(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse L...		Others , Indoleamine 2,3-Dioxygenase (IDO)
T2S1464	Thiocolchicoside	Thiocolchicine 2-glucoside analog,Coltramyl	Others , GABA Receptor
	Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece...		Others , GABA Receptor
T7961	N4-Benzoyl-2′-deoxycytidine		Others
	N4-Benzoyl-2′-deoxycytidine is a synthetic nucleoside analog of the natural nucleoside deoxycytidine (dC), a competitive inhibitor of DNA polymerase. In vitro studies have shown that it inhibits replication in viruses, b...		Others
T5083	L-Cysteic acid monohydrate	3-Sulfo-L-alanine Monohydrate	Endogenous Metabolite , GluR
	L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange of aspartate and...		Endogenous Metabolite , GluR
T6S0659	Rhynchophylline	Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel , NF-κB
	1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c...		Calcium Channel , NF-κB
T0892	Diphylline	Dyphylline,Diprophylline	PDE , Adenosine Receptor
	Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodies...		PDE , Adenosine Receptor
T4S1619	L-Hyoscyamine sulfate	Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate	AChR
	L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits ...		AChR
T0962	L-Hyoscyamine	Daturine,Hyoscyamine	AChR
	L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as w...		AChR
T4752	1-Aminocyclopropane-1-carboxylic acid	1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite , NMDAR
	1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecul...		Endogenous Metabolite , NMDAR
T8270	Deserpidine	Harmonyl	RAAS
	Deserpidine (Harmonyl) is only found in individuals that have used or taken this drug. It is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive propertie...		RAAS
T13752	L-(+)-Arabinose		Endogenous Metabolite
	L-(+)-Arabinose selectively inhibits intestinal sucrase activity in a non-competitive manner, inhibiting glucose elevation caused by sucrose intake.		Endogenous Metabolite
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
TN3013	4,5-Dimethoxycanthin-6-one	Methylnigakinone	P450 , Antibacterial , PDE
	4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae).4,5-Dimethoxycanthin-6-one was isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity.4,5...		P450 , Antibacterial , PDE
T40487	N,N',N''-Triacetylchitotriose
	N,N',N''-Triacetylchitotriose is a competitive inhibitor of lysozyme.
T23772	Balanol	Ophiocordin,BA1,Azepinostatin,(-)-Balanol,(3R-trans)-Balanol
	Balanol is an ATP-competitive Protein Kinase C and Protein Kinase A inhibitor.
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Natural Products

Osthenol

TN1120

Synonym:

Target: MAO, Monoamine Oxidase

Bicuculline

T2850

Synonym: (+)-Bicuculline,d-Bicuculline

Target: GABA Receptor

Obtusin

TN2004

Synonym:

Target: MAO, Monoamine Oxidase

Orobol

TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon

Target: BCL, Caspase, PI3K

Ellagic acid

T0465

Synonym: Gallogen,Elagostasine

Target: Hedgehog/Smoothened, Casein Kinase, Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, PKA, Syk, PKC, Carbonic Anhydrase

Chelerythrine chloride

T3419

Synonym:

Target: Apoptosis, BCL, PKC, Autophagy

Linderene acetate

TN4442

Synonym:

Target: Prolyl Endopeptidase (PREP)

DL-Norvaline

T11054

Synonym: 2-Aminopentanoic acid

Target: Arginase, Endogenous Metabolite

D-(-)-Lactic acid

T10943

Synonym: (R)-2-Hydroxypropionic acid

Target: Others, Endogenous Metabolite

Tolazoline hydrochloride

T1680

Synonym: Imidaline hydrochloride,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride)

Target: Adrenergic Receptor

Decanoic Acid

T3379

Synonym: Decoic acid,CAPRIC ACID,Caprynic acid

Target: GluR, iGluR

Mesaconic acid

T20880

Synonym: Methylfumaric acid,Mesaconate,Kyselina mesakonova

Synonym: 1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin

Target: MAO, Antibacterial, Antibiotic, Antifungal

Aminophylline

T1681

Synonym: Phyllocontin

Target: PDE, Adenosine Receptor

D-Asparagine

TN3748

Synonym: H-D-Asn-OH

Target: Others, Endogenous Metabolite

Calcifediol

T6430

Synonym: U 32070E,25-hydroxy Vitamin D3,RO 8-8892

Target: Endogenous Metabolite

Halofuginone

T6856

Synonym: Tempostatin,empostatin,RU-19110

Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Butyl isobutyl phthalate

T8319

Synonym: ButylIsobutylPhthalate

Target: Glucosidase

Guanidinoethyl sulfonate

T21615

Synonym: Taurocyamine

Target: Chloride channel

Ginsenoside F1

T3401

Synonym: 20(S)-Ginsenoside F1

Target: P450, Endogenous Metabolite

Aminopterin

T7730

Synonym: APGA,4-Aminofolic acid

Target: Antifolate

Ajmalicine

T8044

Synonym: Lamuran,Delta-Yohimbine,Raubasine,Ajmalicin

Target: Adrenergic Receptor

Synonym: Sarcosinic acid,Methylaminoacetic acid,Sarcosin,Methylglycine,N-Methylaminoacetic acid,N-methylglycine

Target: Others, GlyT, Endogenous Metabolite

P-Hydroxyphenethyl trans-ferulate

TN2030

Synonym:

Target: 5-HT Receptor

3-O-Methylquercetin

TN1266

Synonym:

Target: IL Receptor, cAMP, PDE

Staurosporine

T6680

Synonym: Antibiotic AM-2282,AM-2282,CGP 41251

Target: Apoptosis, PKA, Antibacterial, Antibiotic, Src, PKC, Antifungal

8-Geranyloxypsoralen

TN1343

Synonym:

Target: Anti-infection, P450, BACE

(-)-Hydroxycitric acid

T11590

Synonym: Garcinia acid

Target: ATP Citrate Lyase

Niranthin

TN4660

Synonym:

Target: Anti-infection, HBV, PAFR, Topoisomerase

Leupeptin Hemisulfate

T6564

Synonym:

Target: Serine Protease, Cysteine Protease

Malonic acid

T5291

Synonym: Carboxyacetic Acid,1,3-Propanedioic Acid,Propanedioic Acid

Target: Dehydrogenase, NADPH, PDK

Paraxanthine

T4973

Synonym: 1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

(S)-Indoximod

T3S1967

Synonym: N-ME-Tryptophan,Abrine,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Thiocolchicoside

T2S1464

Synonym: Thiocolchicine 2-glucoside analog,Coltramyl

Target: Others, GABA Receptor

N4-Benzoyl-2′-deoxycytidine

T7961

Synonym:

Target: Others

L-Cysteic acid monohydrate

T5083

Synonym: 3-Sulfo-L-alanine Monohydrate

Target: Endogenous Metabolite, GluR

Rhynchophylline

T6S0659

Synonym: Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Diphylline

T0892

Synonym: Dyphylline,Diprophylline

Target: PDE, Adenosine Receptor

L-Hyoscyamine sulfate

T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate

Target: AChR

L-Hyoscyamine

T0962

Synonym: Daturine,Hyoscyamine

Target: AChR

1-Aminocyclopropane-1-carboxylic acid

T4752

Synonym: 1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC

Target: Endogenous Metabolite, NMDAR

Target: Endogenous Metabolite

Tricetin

TN5171

Synonym:

Target: Apoptosis, Others, Nrf2

4,5-Dimethoxycanthin-6-one

TN3013

Synonym: Methylnigakinone

Target: P450, Antibacterial, PDE

N,N',N''-Triacetylchitotriose

Synonym: Ophiocordin,BA1,Azepinostatin,(-)-Balanol,(3R-trans)-Balanol

Target:

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01369	AGRP Protein, Human, Recombinant (His)	Human	HEK293
	Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPJ-00473	QPRTase Protein, Human, Recombinant (His)	Human	E. coli
	Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves ...
TMPH-00893	AHCY Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the...
TMPK-01140	KLRG1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Immune homeostasis requires the tight, tissue-specific control of the different CD4 Foxp3 regulatory T (Treg) cell populations. The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expr...
TMPK-00750	KLRG1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Immune homeostasis requires the tight, tissue-specific control of the different CD4 Foxp3 regulatory T (Treg) cell populations. The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expr...
TMPK-01247	ITGB6 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide ...
TMPK-00839	ITGB6 Protein, Human, Recombinant (His)	Human	HEK293
	ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide ...
TMPH-00227	Beta-casein Protein, Bovine, Recombinant (His & Myc)	Bovine	E. coli
	Important role in determination of the surface properties of the casein micelles.; Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It als...
TMPH-02941	MAFK Protein, Mouse, Recombinant (His & Myc & SUMO)	Mouse	E. coli
	Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they act as transcriptional activators by dimerizing with other (usuall...
TMPH-02940	MAFK Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293
	Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they act as transcriptional activators by dimerizing with other (usuall...
TMPH-01761	Neuroglobin Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhi...
TMPY-00661	AGRP Protein, Human, Recombinant (hFc)	Human	HEK293
	Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPY-00630	AGRP Protein, Rhesus, Recombinant (mFc)	Rhesus	HEK293
	Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPJ-01309	PKI-Beta Protein, Human, Recombinant (His)	Human	E. coli
	cAMP-Dependent Protein Kinase Inhibitor β (PKI-β) is a member of the PKI family. As a member of the cAMP-dependent protein kinase inhibitor family,It has been shown that PKI-β is an extremely potent competitive inhibitor...
TMPY-00434	AGRP Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPY-02269	AGRP Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist ...
TMPH-01092	CHGA Protein, Human, Recombinant (His)	Human	Yeast
	Strongly inhibits glucose induced insulin release from the pancreas.; Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displa...
TMPH-01885	PABPC1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can eithe...
TMPY-01769	4EBP1 Protein, Human, Recombinant (His)	Human	E. coli
	The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcrip...