Shopping Cart

Your shopping cart is currently empty

Disodium monofluorophosphate

Name: Disodium monofluorophosphate
Brand: TargetMol
SKU: T0745
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T0745Cas No. 10163-15-2

Alias NSC248

Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.

Disodium monofluorophosphate

Copy Product Info

😃Good

Catalog No. T0745Alias NSC248Cas No. 10163-15-2

Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Disodium monofluorophosphate AI Summary

Disodium monofluorophosphate demonstrates antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in both Caco-2 and VERO-6 cells. In Caco-2 cells, it showed a 7.36% inhibition rate at a concentration of 10 µM after 48 hours, as determined by high content imaging. In VERO-6 cells, it exhibited a 0.03% inhibition rate under similar conditions. Additionally, Disodium monofluorophosphate inhibits the SARS-CoV-2 3CL-Pro protease, achieving a 15.04% inhibition at a concentration of 20 µM in a FRET assay using a peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.
Targets&IC50	Phosphorylase phosphatase:0.5 mM(Ki), ALP:69 μM(Ki), Pyruvate kinase:3.4 mM(Ki)
In vitro	Monofluorophosphate showed potent activity against bone immobilization in vivo. Drinking water containing 50 ppm Monofluorophosphate showed a significant increase in bone disease in mobile and immobile tibia (1.48 and 0.98 mM, respectively, and 0.79 and 0.40 mM, respectively) as compared to the fluoride-free water group. Monofluorophosphate increased the rate of bone mineralization and counteracted immobilization-induced decreases in bone thickness, ash content, and specific gravity without altering the Ca/P ratio of ash.Monofluorophosphate had no effect on the specific gravity of immobilized and immobilized tibiae in rats.
In vivo	Monofluorophosphate showed potent activity against bone immobilization in vivo. Drinking water containing 50 ppm Monofluorophosphate showed a significant increase in bone disease in mobile and immobile tibia (1.48 and 0.98 mM, respectively, and 0.79 and 0.40 mM, respectively) as compared to the fluoride-free water group. Monofluorophosphate increased the rate of bone mineralization and counteracted immobilization-induced decreases in bone thickness, ash content, and specific gravity without altering the Ca/P ratio of ash.Monofluorophosphate had no effect on the specific gravity of immobilized and immobilized tibiae in rats.
Synonyms	NSC248

Chemical Properties

Molecular Weight	143.95
Formula	FNa₂O₃P
Cas No.	10163-15-2
Smiles	O=P([O-])(F)[O-].[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	DMSO: < 1 mg/mL (insoluble or slightly soluble)

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc