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AZ'320
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Catalog No. T211816
AZ'320 is an ATP-competitive necroptosis inhibitor with an EC50 value of 4.9 μM and a RIPK1 inhibitor with a pKD value of 5.45. It functions by inhibiting RIPK1 phosphorylation, thereby suppressing necroptosis. In systemic inflammatory response syndrome (SIRS) model mice, AZ'320 reduces mortality and restores temperature and weight. This compound can be utilized in cancer and inflammation research.
AZ'320
AZ'320
😃Good
Catalog No. T211816
AZ'320 is an ATP-competitive necroptosis inhibitor with an EC50 value of 4.9 μM and a RIPK1 inhibitor with a pKD value of 5.45. It functions by inhibiting RIPK1 phosphorylation, thereby suppressing necroptosis. In systemic inflammatory response syndrome (SIRS) model mice, AZ'320 reduces mortality and restores temperature and weight. This compound can be utilized in cancer and inflammation research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | AZ'320 is an ATP-competitive necroptosis inhibitor with an EC50 value of 4.9 μM and a RIPK1 inhibitor with a pKD value of 5.45. It functions by inhibiting RIPK1 phosphorylation, thereby suppressing necroptosis. In systemic inflammatory response syndrome (SIRS) model mice, AZ'320 reduces mortality and restores temperature and weight. This compound can be utilized in cancer and inflammation research. |
| In vitro | AZ’320 inhibits the phosphorylation level of RIPK1 at the Ser166 site in 12.1 cells in a dose-dependent manner when administered at concentrations of 0.1-10 μM for 4 hours. |
| In vivo | AZ'320 (5 mg/kg, administered intravenously 15 minutes prior to TNF stimulation) reduces mortality in mice models of systemic inflammatory response syndrome (SIRS) and helps restore body temperature and weight, achieving effects comparable to those of Nec-1. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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