cell growth

Bovine Endothelial cell growth supplement is a medium additive that acts as an endothelial cell growth supplement (ECGS), enhancing the proliferation of human saphenous vein endothelial cells (HSVEC) and human umbilical vein endothelial cells (HUVEC).

Boscalid is a broad-spectrum carboxamide fungicide that inhibits fungal respiration by binding to the ubiquinone site of mitochondrial complex II/succinate dehydrogenase.1It suppresses mycelial growth ofS. minorby 87 to 100% and ofS. sclerotiorumby 77 to 100% when used at a concentration of 1 μg/ml.2In field studies, boscalid applied at 5.6 μg/cm2provides 55.5 and 30.4% disease control for lettuce drop caused byS. minorandS. sclerotiorum, respectively. It decreases cell viability of mouse primary cortical neurons following long-term exposure but is not cytotoxic (LC50= >100 μM for acute and continuous exposure). Formulations containing boscalid have been used in agriculture to prevent fungal growth on crops. 1.Wang, Y., Duan, Y., Wang, J., et al.A new point mutation in the iron-sulfur subunit of succinate dehydrogenase confers resistance to boscalid in Sclerotinia sclerotiorumMol. Plant Pathol.16(7)653-661(2015) 2.Matheron, M.E., and Porchas, M.Activity of boscalid, fenhexamid, fluazinam, fludioxonil, and vinclozolin on growth of Sclerotinia minor and S. sclerotiorum and development of lettuce dropPlant Dis.88(6)665-668(2004)

N-Ethyl-o-toluidine is a drug with genotoxicity and anticancer potential, exhibiting >70% growth inhibition against yeast strains with specific genetic alterations. It can also serve as an intermediate in dye synthesis.

Magnesium Sulfate Heptahydrate is a biochemical reagent suitable for cell culture, which can be added to culture media to support microbial growth.

Fetuin (Fetal Bovine Serum) is a glycoprotein purified from foetal bovine serum, primarily employed as an additive in cell culture to promote cell adhesion and growth. Fetuin is the protein product of the AHSG gene, naturally occurring in serum and extracellular fluids. It inhibits calcification and cysteinopeptidases, antagonises TGF-β, reduces insulin sensitivity, and more.

1,2-Dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) ammonium is a membrane-associated signaling molecule that plays a crucial role in cell physiology. It is involved in regulating cell growth, metabolism, proliferation, and survival, and participates in various signal transduction pathways, significantly influencing intracellular signal transmission.

Lipid PPz-2R1 is an ionizable cationic lipid employed in crafting lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. LNPs with lipid PPz-2R1, encapsulating an mRNA reporter, target the lungs preferentially over the heart, liver, spleen, and kidneys in mice. Additionally, these LNPs, when encapsulating mRNA encoding phosphatase and tensin homolog (PTEN), enhance PTEN protein levels in PTEN-deficient Lewis lung carcinoma (LLC) cells. In an orthotopic murine LLC model, these Lipid PPz-2R1-containing LNPs, carrying PTEN mRNA, reduce tumor growth either when administered alone or alongside an antibody against programmed cell death protein 1 (PD-1).

Holo-Human transferrin is an iron-loaded glycoprotein that serves as the primary iron-transporting molecule in human serum. Holo-Human transferrin binds ferric ions with high affinity and mediates their cellular uptake through transferrin receptor interactions, ensuring physiological iron homeostasis. Holo-Human transferrin is widely used in serum-free cell culture systems to provide bioavailable iron in a physiologically relevant form, supporting cellular growth and metabolism across diverse cell types.

ST3 β-Gal α-2,3-Sialyltransferase 1 (ST3GAL1) is a sialyltransferase enzyme that, when overexpressed in ovarian cancer cell lines, enhances cell growth, migration, and invasion, while also increasing tumorigenicity and resistance to paclitaxel in vivo. ST3GAL1 catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates and is useful in studies of cancer progression and chemotherapy resistance.

HEPES Solution (1M, Sterile) is a highly effective biological buffer with a pKa of approximately 7.5 and a buffering range of pH 6.8–8.2. HEPES Solution (1M, Sterile) is widely used in cell culture to maintain stable pH in culture media, particularly in environments where CO₂ concentration is difficult to precisely control. HEPES Solution (1M, Sterile) ensures cells maintain stable growth under near-physiological conditions and minimizes experimental interference caused by pH fluctuations.

Trimethylsilyl-L-(+)-rhamnose, a chemically modified version of the natural sugar rhamnose, is utilized for studying the role of rhamnose in bacterial cell walls. [Trimethylsilyl-L-(+)-rhamnose] can be used to investigate the composition and biological functions of bacterial cell walls, aiding scientists in understanding bacterial growth and resistance mechanisms.

D-Fructose 6-phosphate dipotassium is an endogenous metabolite found in saliva that influences cell growth and autophagy. It is produced by the hydrolysis of Fructose-1,6-bisphosphatase (FBPase). Under the action of phosphoglucose isomerase, D-Fructose 6-phosphate dipotassium can be converted into D-glucose 6-phosphate . This compound acts as a sugar intermediate in both the glycolysis and pentose phosphate pathways. D-Fructose 6-phosphate dipotassium is used in research related to Lewy body dementia.

Silver nitrite, with the chemical formula AgNO2, is an inorganic compound. It can inhibit cell division and bacterial growth by interfering with protein synthesis.

Linoleate sodium is an orally active regulator of IL8 mediated by JNK and NF-κB pathways. It can alter the composition of fatty acids and the production of metabolites within cells. Additionally, Linoleate sodium exhibits anti-inflammatory, immunomodulatory properties and influences tumor cell growth.

Tetrazolium violet is a redox indicator extensively employed in biochemical assays to assess cell viability and metabolic activity. Its unique chemical properties allow it to be reduced by cellular enzymes like dehydrogenases, forming a purple formazan product that is detectable via spectrophotometry. This makes it a valuable tool for evaluating cell health and growth in culture or tissue samples.

N4,N9-di-Boc-spermine is a spermine linker characterized by two Boc-protected amine groups and two additional amine groups. The Boc groups can be removed under mild acidic conditions to yield free amines. These amino groups can react with carboxylic acids, activated NHS esters, and carbonyl compounds (ketones, aldehydes). Spermidine, a polyamine, plays a role in regulating various cellular activities including cell growth and differentiation, DNA stability, and apoptosis.

N1,N12-Di-Boc-spermine is a spermine derivative that contains two Boc-protected amino groups. The Boc groups can be removed under mild acidic conditions to yield free amines. Spermidine, a related polyamine, plays a role in regulating diverse cellular processes, such as cell growth and differentiation, DNA stability, and apoptosis.

(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.

(S)-GSK-3685032 is an isomer of GSK-3685032 and serves as a control compound in experiments. GSK-3685032 is a selective inhibitor of DNMT1, characterized by its non-time-dependent, non-covalent, and reversible nature, with an IC50 of 0.036 μM. It induces loss of DNA methylation, transcription activation, and inhibition of cancer cell growth.