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Results for "

t-cells

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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Alemtuzumab
T9919216503-57-0
Alemtuzumab is a humanized monoclonal antibody against CD52 an antigen found on the surface of normal and malignant lymphocytes.
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Atezolizumab
T99021380723-44-3
Atezolizumab is an antibody inhibitor, a humanized monoclonal antibody, IgG1, which targets PD-L1 and blocks the interaction of PD-L1 with PD-1. Atezolizumab has antitumor activity and promotes T-cells to attack tumor cells.
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TargetMol | Inhibitor Hot
Nivolumab
T9907946414-94-4
Nivolumab is a monoclonal antibody, a humanized IgG4 antibody to PD-1. Nivolumab has antitumor activity and is used in the treatment of melanoma, non-small cell lung cancer, renal cell carcinoma and others.
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TargetMol | Inhibitor Hot
Pembrolizumab
Pembrolizumab(anti-PD-1)
T99081374853-91-4
Pembrolizumab (MK-3475) is a humanized monoclonal antibody inhibiting the PD-1 receptor and the first in the class of agents called the HER2 dimerization inhibitors that impairs the ability of HER2 to bind to other members of the HER family.
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TargetMol | Inhibitor Hot
TargetMol
ABP-102
CTP72, CT P72, ABP102
T9901A-750
ABP-102 (CT P72) is a tetravalent IgG1-[L]-scFv bispecific t-cell adduct (BiTE) that acts as a CD3 modulator and selective HER2 modulator for the selective targeting of HER2 overexpressing tumors. ABP-102 showed cytotoxicity in HER2-overexpressing models of breast and gastric cancers, while significantly decreasing activity against HER2 low level cells, twice as effective as rununmotamab.
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Cibisatamab
T766741855925-27-7
Cibisatamab is a T-cell bispecific antibody that acts as a T-cell splicer.Cibisatamab targets carcinoembryonic antigen (CEA) on cancer cells and CD3 on T-cells, and triggers T-cell killing when the CEA on the surface of the cancer cells ranges from intermediate to high levels.Cibisatamab may be used to study solid cancers such as colorectal cancer.
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Mosunetuzumab
BTCT-4465A
T766921905409-39-3
Mosunetuzumab (BCT-4465A) is a humanized antibody based on immunoglobulin G1 that targets CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used to study relapsed or refractory (R R) B-cell non-Hodgkin lymphoma (B-NHL) and refractory follicular lymphoma.
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Odronextamab
T766941801338-64-6
Odronextamab, a fully human, hinge-stabilized IgG4-based bispecific antibody, targets CD3 receptors on T cells and CD20 receptors on B cells [1].
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2-4 weeks
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Vudalimab
T767282329669-72-7
Vudalimab, a fully humanized bispecific monoclonal antibody, effectively inhibits both PD-1 and CTLA-4 immune checkpoint receptors. This dual action facilitates the selective activation of T-cells targeting tumors.
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2-4 weeks
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Foralumab
NI-0401, NI0401
T76748946415-64-1
Foralumab (NI-0401) is an orally available human anti-CD3 monoclonal antibody that downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells from COVID-19 subjects for the study of COVID-19 infection.
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Rolinsatamab
T767732095467-30-2
Rolinsatamab is a fully humanized selective monoclonal antibody that is a potent dual inhibitor of IL-4 and IL-13. Rolinsatamab chimeric antigen receptor sequence T cells. Rolinsatamab can be used to prevent and treat immune diseases.
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Mogamulizumab
KW-0761
T767821159266-37-1
Mogamulizumab (KW-0761) is a monoclonal antibody targeting T cell CC chemokine receptor 4. It exhibits anticancer activity by eliminating tumor cells through antibody-dependent cytotoxicity (ADCC) and can be used in the study of cancer, adult T-cell leukemia lymphoma (ATLL), and cutaneous T-cell lymphoma (CTCL).
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Toralizumab
T76834252662-47-8
Toralizumab (IDEC-131), a humanized monoclonal antibody (mAb) directed against CD40L (CD154), consists of human gamma 1 heavy chains and human kappa light chains. Specifically targeting CD40L on T cells, it inhibits CD40 signaling, acting as an immunosuppressive agent with potential applications in systemic lupus erythematosus (SLE) research [1] [2].
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2-4 weeks
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Gresonitamab
T768552413817-97-5
Gresonitamab (AMG 910), a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody, specifically targets CD3-positive T cells and CLDN18.2-expressing tumor cells, offering potential research applications in adenocarcinoma [1].
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2-4 weeks
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Bavunalimab
T768592329669-78-3
Bavunalimab (Anti-Human CTLA4xLAG3), a bispecific human monoclonal antibody targeting CTLA-4 and LAG-3, activates T cells in NSG mice and is utilized in cancer research [1].
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Neihulizumab
T768722158362-38-8
Neihulizumab (ALTB-168), an immune checkpoint agonistic antibody, targets and binds to human CD162 (PSGL-1), resulting in the downregulation of activated T-cells. It is utilized in research aimed at treating steroid-refractory acute graft-versus-host disease (SR-aGVHD), psoriasis, psoriatic arthritis, and ulcerative colitis [1].
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2-4 weeks
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Tepoditamab
T768802044679-53-8
Tepoditamab (MCLA-117) is a bispecific monoclonal antibody targeting CLEC12A on myeloid cells and CD3 on cytotoxic T cells. As a myeloid differentiation antigen, CLEC12A allows the compound to eliminate AML leukemia progenitor and stem cells through T cell-mediated proliferative lysis, making it valuable in acute myeloid leukemia (AML) research [1].
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2-4 weeks
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Teclistamab
JNJ-64007957, JNJ64007957
T768812119595-80-9
Teclistamab (JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor expressed on the surface of t-cells and the b-cell maturation antigen (BCMA) expressed on the surface of malignant multiple myeloma b-lineage cells for the treatment of relapsed and refractory multiple myeloma.
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8-10 weeks
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Talquetamab
JNJ-7564, JNJ-64407564
T768822226212-40-2
Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.
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Efalizumab
Hu1124, HU 1124
T76924214745-43-4
Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinocytes, and can be used to study plaque psoriasis and psoriatic arthritis.
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Vibecotamab
T769592138442-13-2
Vibecotamab (XmAb14045) is a potent bispecific antibody that targets CD123 and CD3, promoting T cell-mediated elimination of CD123-expressing cells. It exhibits antitumor properties and is used in studies on acute myeloid leukemia [1].
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2-4 weeks
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Vepsitamab
T769612413453-53-7
Vepsitamab (AMG 199) is an anti-MUC17 CD3 BiTE antibody that targets CD3 on T cells and MUC17 on tumor cells, promoting targeted tumor cell destruction and stimulating T cell activation and proliferation [1].
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2-4 weeks
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Tebotelimab
T769852245725-04-4
Tebotelimab (MGD-013) is a bispecific antibody targeting PD-1 and LAG-3, classified as a human IgG4κ dual-affinity re-targeting (DART) molecule. It has binding affinities with EC50 values of 1.65 nM for PD-1 and 0.41 nM for LAG-3 on NS0 cells. The compound inhibits PD-1 PD-L1, PD-1 PD-L2, and LAG-3 HLA (MHC-II) interactions, as well as PD-1 signaling pathways, thereby reinvigorating exhausted T-cell responses and bolstering antitumor immunity [1] [2] [3].
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2-4 weeks
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Cevostamab
T769982249888-53-5
Cevostamab (BFCR4350A; RG6160; RO7187797), a humanized IgG1-based bi-specific antibody (BsAb), specifically targets the membrane-proximal extracellular domain of FcRH5 on multiple myeloma (MM) cells and CD3 on T cells. It enhances synapse formation and augments T cell-mediated killing of MM tumor cells [1] [2].
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2-4 weeks
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