pan — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16432	Pan-RAS-IN-1		MAPK , Ras
	Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.		MAPK , Ras
T1982	3-AP	NSC663249,Triapine,PAN-811,OCX191	DNA/RNA Synthesis
	3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).		DNA/RNA Synthesis
T70956	JNJ-pan-AR
	JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent an...
T79814	pan-KRAS-IN-3		Ras
	Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].		Ras
T63475	Pan-Trk-IN-2
	Pan-Trk-IN-2 is a small molecule Trks inhibitor that exhibits promising antitumor effects.
T79800	pan-KRAS-IN-2		Ras
	Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly...		Ras
T62621	pan-HER-IN-2
	pan-HER-IN-2 (Compound C6) is an orally active, reversible, broad-spectrum HER inhibitor that acts on EGFR (IC50: 0.72 nM), HER4 (IC50: 2.0 nM), EGFRT790M (IC50: 8.2 nM), and L858R (IC50: 75.1 nM). pan-HER-IN-2 induces a...
T62047	pan-HER-IN-1
	pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan- HER inhibitor. pan-HER-IN-1 exhibits IC 50s of 0.38, 1.6, 2.2 and 3.5 nM for EGFR, HER4, EGFR T790M/L858R and HER2, respectively. pan-HER-IN-1 induces apo...
T79799	pan-KRAS-IN-4		Ras
	Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].		Ras
T64070	Pan-Trk-IN-3
	Pan-Trk-IN-3 is a potent, broad-spectrum inhibitor of Trk and its drug-resistant mutants, acting on TrkA (IC50: 2 nM), TrkB (IC50: 3 nM), TrkC (IC50: 2 nM), TrkAG595R (IC50: 21 nM), TrkAG667C (IC50: 26 nM), TrkAG667S (IC...
T63386	Pan-RAF kinase inhibitor 1
	Pan-RAF kinase inhibitor 1 is a potent inhibitor of the Pan-RAF kinase pair that inhibits RAF kinase and regulates MAPK signaling, thereby affecting the proliferation of RAS-mutated tumor cells. Pan-RAF kinase inhibitor ...
T74847	PROTAC pan-IAP degrader-1
	PROTAC pan-IAP degrader-1 (Compound 9) is a pan- IAP degrader PROTAC . PROTAC pan-IAP degrader-1 degrades XIAP , cIAP1 and cIAP2 with DC 50 s of 0.7, 2.4, and 6.2 nM in MM.1S cells, respectively [1] .
T8224	VU0119498		AChR
	VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.		AChR
T68655	PAN12314
	PAN12314, also known as Compound 5a, is a 5-HT4R partial agonists that displayed cognition-enhancing properties in animal models. This product has no formal name at the moment. For the convenience of communication, a te...
T0987	Gimeracil	Gimestat	Autophagy
	Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.		Autophagy
T70954	SP-187 HCl
	SP-187, also known as N-9-DNJ and UV-4B, is an alpha-Glucosidase inhibitor potentially for the treatment of dengue fever and influenza infection. Proline-producing strains of Serratia marcescens were more osmotolerant t...
T7020	Z-VAD-FMK	Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD	Caspase
	Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases with irreversible properties. Z-VAD-FMK binds to activated caspases, thereby inhibiting apoptosis.		Caspase
T14998	Copanlisib dihydrochloride	BAY 80-6946 dihydrochloride	Apoptosis , PI3K , mTOR
	Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Copanlisib dihydrochloride has super...		Apoptosis , PI3K , mTOR
T5243	(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate	DMPE,1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine,1,2-Dimyristoyl-sn-glycero-3-PE	Others , Endogenous Metabolite
	(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate (DMPE) is a phosphatidylethanolamine (PE or GPEtn). It is a glycerophospholipid in which a phosphorylethanolamine moiety occupies a glycer...		Others , Endogenous Metabolite
T65636	BIS-TRIS propane	BTP	Others
	BIS-TRIS propane (BTP), a novel multidentate ligand of nickel- and cobalt-based spin clusters, is a metal chelator. BIS-TRIS propane is often used as a zwitterionic buffer for PCR and protein crystallization studies.		Others