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  • DNA/RNA Synthesis
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    (37)
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    (35)
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Results for "

dna/rna

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    572
    TargetMol | Inhibitors_Agonists
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    6
    TargetMol | Compound_Libraries
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    6
    TargetMol | Peptide_Products
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    TargetMol | Dye_Reagents
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    131
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    TargetMol | Recombinant_Protein
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    TargetMol | Inhibitors_Agonists
Oxaliplatin
L-OHP
T016461825-94-3
Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy.
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TargetMol | Inhibitor Hot
Gemcitabine
NSC 613327, LY188011
T025195058-81-4
Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
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5-Fluorouracil
NSC 19893, Fluorouracil, 5-FU, 5-Fluoracil
T098451-21-8
5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.
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Fludarabine
NSC 118218, Fludarabinum, F-ara-A
T103821679-14-1
Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.
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TargetMol | Inhibitor Hot
Temozolomide
TZM, TMZ, NSC 362856, CCRG 81045
T117885622-93-1
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions.
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TargetMol | Inhibitor Hot
Cycloheximide
Naramycin A, CHX, Actidione
T122566-81-9
Cycloheximide (Naramycin A) is a natural product that reversibly inhibits translation elongation, is an antimitotic compound, and is an inhibitor of DNA and protein synthesis.
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TargetMol | Inhibitor Hot
Calf thymus DNA
DNA from calf thymus, Thymonucleic acid
T1359291080-16-9
Calf thymus DNA (DNA from calf thymus, Thymonucleic acid) is a high-quality double-stranded template DNA extracted from the bovine thymus gland, widely used in studying DNA binding anticancer agents and DNA binding agents that regulate DNA structure and function.
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TargetMol | Inhibitor Hot
Streptozocin
U 9889, STZ, Streptozotocin, NSC-85998
T150718883-66-4
Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. The product is unstable in solution and is recommended to be dispensed now.
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TargetMol | Inhibitor Hot
Resveratrol
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
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TargetMol | Inhibitor Hot
Cisplatin
cis-Diaminodichloroplatinum, CDDP
T156415663-27-1
Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates ferroptosis and induces autophagy.
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TargetMol | Inhibitor Hot
Risdiplam
RO7034067, RG7916
T167571825352-65-5
Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.
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TargetMol | Inhibitor Hot
Puromycin dihydrochloride
Puromycin 2HCl, CL13900 dihydrochloride
T221958-58-2
Puromycin dihydrochloride (CL13900 dihydrochloride) is a cinnamamide adenosine antibiotic and an inhibitor of protein synthesis. Puromycin dihydrochloride inhibits protein synthesis by binding to RNA and has antitumor and antitrypanosomal activity.
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TargetMol | Inhibitor Hot
Orellanine
2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one
T3381737338-80-0
Orellanine is a nephrotoxic compound extracted from the mushroom Cortinarius orellanus. Orellanine strongly inhibits the synthesis of macromolecules (Proteins, RNA and DNA) in Madin-Darby canine kidney cells and in rat liver mitochondria.
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6-8 weeks
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TargetMol | Inhibitor Hot
Bleomycin Sulfate
NSC125066, Blenoxane
T61169041-93-4
Bleomycin Sulfate (Blenoxane) is a glycopeptide antibiotic, an inhibitor of DNA synthesis. Bleomycin Sulfate causes DNA strand breaks but not RNA strand breaks. Bleomycin Sulfate has antitumor activity.
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TargetMol | Inhibitor Hot
Bleomycin hydrochloride
T6116L67763-87-5
Bleomycin hydrochloride is a potent antitumor antibiotic that functions as a DNA synthesis inhibitor and DNA damaging agent.
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7-10 days
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TargetMol | Inhibitor Hot
NSC 228155
NSC228155
T6908113104-25-9
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulating EGFR tyrosine phosphorylation.
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TargetMol | Inhibitor Hot
Werner syndrome RecQ helicase-IN-1
T721072869954-34-5
Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
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10-14 weeks
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TargetMol | Inhibitor Hot
aoh1996
T775202089314-64-5In house
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
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7-10 days
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TargetMol | Inhibitor Hot
ART558
T92752603528-97-6
ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.
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TargetMol | Inhibitor Hot
AOH1160
N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide
T103432089314-57-6In house
AOH1160 is an inhibitor of proliferating cell nuclear antigen (PCNA). AOH1160 induces apoptosis and causes cell-cycle arrest by interfering with DNA replication.
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6-8 weeks
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Galidesivir
BCX4430, Immucillin-A
T10491249503-25-1In house
Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and reduces lung infections in infected animals.
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10-14 weeks
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d-i03
DI03
T10936688342-78-1In house
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. It specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC50 values of 5 µM and 8 µM, respectively. D-I03 also inhibits the growth of BRCA1 and BRCA2 deficient cells and prevents the formation of damage-induced RAD52 foci, but does not affect RAD51 foci induced by Cisplatin.
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6-8 weeks
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SMN-C3
MV8T2MCK57
T129351449597-34-5In house
SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).
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8-10 weeks
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TTP-8307
TTP8307
T13221950225-08-8In house
TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses, and inhibits coxsackievirus B3 and poliovirus by interfering with viral RNA synthesis.TTP-8307 can be used in the study of viral infections.
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6-8 weeks
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