class

Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.

Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, Sulconazole mononitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.

Indophagolin is a potent, indoline-containing autophagy inhibitor with an IC50 of 140 nM, and it antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40, and 3.49 μM, respectively.

Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a, κ antibody inhibitor specifically targeting mouse MHC Class I.

Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is an IgG2a, κ inhibitor antibody derived from mice that targets mouse MHC Class I molecules.

Anti-MHC Class I Antibody (W6/32) is a mouse IgG2a, κ chimeric antibody specifically targeting human MHC Class I molecules. Recommended isotype control for Anti-MHC Class I Antibody (W6/32) is Mouse IgG2a kappa, Isotype Control.

Anti-Mouse MHC Class II (β chain) Antibody (KL277) is an IgG antibody inhibitor sourced from hamster or mouse and targets mouse MHC Class II.

Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is an IgG2a, κ inhibitory antibody derived from mice and targets mouse MHC class II proteins.

Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As, I-Ag7) Antibody (10-3.6.2) is an IgG2c, κ antibody inhibitor derived from mice, targeting murine MHC Class II molecules.

Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) is an IgG2b, κ antibody inhibitor derived from mouse, targeting Swine MHC Class I.

Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is an IgG2a, κ antibody inhibitor derived from mice, designed to target MHC Class II in both mice and rats.

Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) is an IgG1 antibody inhibitor derived from mice, targeting mouse MHC Class I.

Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) is an IgG2a, κ antibody inhibitor derived from mice that targets mouse MHC Class I.

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is an IgG2b antibody inhibitor derived from rats, specifically targeting mouse MHC Class II.

Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) is an IgG2a, κ antibody inhibitor derived from mice that targets monkey or human MHC class II.

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) is an IgG2a, κ antibody inhibitor derived from mice and targets murine MHC Class I.

MHC class II antigen (45-57) [Homo sapiens] is a peptide with the sequence H2N-Asp-Leu-Asp-Lys-Lys-Glu-Thr-Val-Trp-His-Leu-Glu- Glu-OH, MW= 1868.07. MHC (major histocompatibility complex) class II molecules are found only on antigen-presenting cells and l

Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stress responses in the body.

Doxorubicin hydrochloride is an anthracycline antibiotic with cytotoxic and antitumor activity. It is an effective inhibitor of human DNA topoisomerase I and II, with IC50 values of 0.8 μM and 2.67 μM, respectively. In addition to inhibiting DNA topoisomerases, it can reduce the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase. Doxorubicin hydrochloride also induces apoptosis and autophagy. In animal studies, it is commonly used to induce models of acute renal failure, chronic kidney injury, and heart failure.

Durlobactam sodium salt (ETX2514) is a beta-lactamase inhibitor with IC50 values of 4 nM, 14 nM and 190 nM against class A KPC-2, class C AmpC and class D OXA-24.

Doxycycline is an orally active tetracycline antibiotic with broad-spectrum inhibitory effects on matrix metalloproteinases (MMPs), possessing both antibacterial and antitumor activities, and is commonly used in inducible gene expression ON-OFF systems.

Doxycycline (hyclate) is an orally active tetracycline antibiotic with broad-spectrum inhibitory activity against matrix metalloproteinases (MMPs), possessing both antibacterial and antitumor properties, and is commonly used in inducible gene expression ON-OFF systems.

3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50 = 60 μM) and class III VPS34 (IC50 = 25 μM). 3-Methyladenine inhibits autophagy.

Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2].